Results 81 to 90 of about 4,101,858 (162)

24-Hydroxycholesterol Moderates the Effects of Amyloid-β on Expression of HMG-CoA Reductase and ABCA1 Proteins in Mouse Astrocytes. [PDF]

Adv Biomed Res, 2023
Nazeri Z, Mohammadzadeh G, Rashidi M, Azizdoost S, Cheraghzadeh M, Kheirollah A.   +5 more
europepmc   +1 more source

Niemann-Pick disease type C1: 24(S)-hydroxycholesterol pre/post adrabetadex

Cerebrospinal fluid 24(S)hydroxycholesterol levels pre and post (48 hr) administration of intrathecal adrabetadex/VTS270?HPBCD in individuals with Niemann-Pick disease type ...
Porter, Forbes
core   +1 more source

Bobbing of 27-hydroxycholesterol.

, 2018
<p>Movie showing the bobbing of 27-hydroxycholesterol.</p ...
Kulig, Waldemar, Kulig, Waldemar (5268277)   +1 more
core   +1 more source

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder

Children
The NR1H2 gene produces the Liver X Receptor Beta (LXRB) protein, which is crucial for brain cholesterol metabolism and neuronal development. However, its involvement in autism spectrum disorder (ASD) remains largely unexplored, aside from animal studies.
Tuğba Menteşe Babayiğit, Güvem Gümüş-Akay, Merve Çikili Uytun, Özlem Doğan, Muhittin A. Serdar, Gökçe Yağmur Efendi, Ayşe Gökçe Erman, Esra Yürümez, Didem Behice Öztop   +8 more
doaj   +1 more source

Could 24-S-hydroxycholesterol play a role in Müller glial cell's membrane dynamics in the rat

, 2016
National audiencePurpose The catabolism of cholesterol in neurons leads to a more hydrophilic compound soluble form, the 24‐S‐hydroxycholesterol by means of an enzyme the CYP46A1.The aim of this study was to analyse the implication of 24‐S ...
Brétillon, Lionel, Gambert Nicot, Ségolène, Bron, Alain M., Ferrero, A., Acar, Niyazi, Creuzot Garcher, Catherine   +5 more
core   +1 more source

Serum 4β-hydroxycholesterol increases during fluconazole treatment

, 2020
Purpose: The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity.
Kerksiek, Anja, Lötsch, Jörn, Stellaard, Frans, Lütjohann, Dieter, Oertel, Bruno Georg, Oertel, Bruno G   +5 more
core   +2 more sources

Ventriculoperitoneal Shunt Treatment Increases 7 Alpha Hy-Droxy-3-Oxo-4-Cholestenoic Acid and 24-Hydroxycholesterol Concentrations in Idiopathic Normal Pressure Hydrocephalus. [PDF]

Brain Sci, 2022
Porru E, Edström E, Arvidsson L, Elmi-Terander A, Fletcher-Sandersjöö A, Sandblom AL, Hansson M, Duell F, Björkhem I.   +8 more
europepmc   +1 more source

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models

Neuroscience Research
We investigated whether soticlestat (TAK-935), a newly discovered cholesterol 24-hydroxylase (CH24H) inhibitor now in phase 3 clinical trials for Dravet and Lennox-Gastaut syndromes, has effects on neurodegeneration in both chronic and acute animal ...
Shigeo Hasegawa, Sayuri Watanabe, Shinji Fujimoto, Shinichi Kondo, Toshiya Nishi   +4 more
doaj   +1 more source

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers

Journal of Lipid Research, 2003
The side chain oxidized oxysterol 24S-hydroxycholesterol (24-OH-chol) is formed almost exclusively in the brain, and there is a continuous passage of this oxysterol through the circulation to the liver.
Valerio Leoni, Thomas Masterman, Pria Patel, Steve Meaney, Ulf Diczfalusy, Ingemar Björkhem   +5 more
doaj   +1 more source

Modulation of lipid membrane organization of Müller Glial Cells (MGC) by 24-(S)-hydroxycholesterol (24-S-OHC) in glaucoma: Session 3: Nutrition and oxysterols biological activities

, 2016
ENO= the European Network for Oxysterol ResearchENO= the European Network for Oxysterol ResearchModulation of lipid membrane organization of Müller Glial Cells (MGC) by 24-(S)-hydroxycholesterol (24-S-OHC) in glaucoma. Session 3: Nutrition and oxysterols
Brétillon, Lionel, Martine, Lucy, Gabrielle, Pierre Henry, Gendrault, Clément, Lachot, Méline, Ferrero, Arthur, Gambert, Ségolène, Masson, Elodie A.Y., Masson, Elodie, Leclere, Laurent   +9 more
core   +1 more source