Results 111 to 120 of about 2,904,339 (217)

Relevance of 24S-hydroxycholesterol as a biomarker of optic neuropathies

, 2010
Purpose: 24S-Hydroxycholesterol is formed by enzymatic oxidation of cholesterol via cholesterol-24S-hydroxylase (CYP46A1) activity in neurons, including retinal ganglion cells and neurons from the inner retina. We investigated whether neurodegeneration could be associated with the release of 24S-hydroxycholesterol in acute neuropathies, and therefore ...
Brétillon, Lionel, Martine, Lucy, Pasquis, Bruno, Fourgeux, Cynthia, Schnebelen, Coralie, Acar, Niyazi, Bjorkhem, Ingemar, Bron, Alain, Creuzot Garcher, Catherine   +8 more
openaire   +2 more sources

Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages

Journal of Lipid Research, 1996
We have defined the lipid composition of copper-oxidized LDL (Cu-oxLDL) and a macrophage-foam cell model generated by the uptake of this modified lipoprotein.
A J Brown, R T Dean, W Jessup
doaj   +1 more source

Exploring biomarkers of neurodegenerative risk: associations of oxysterols, sex hormones, and reproductive characteristics in older women

Journal of Lipid Research
Women face a higher lifetime risk of developing neurodegenerative diseases such as Alzheimer’s disease and related dementias. The menopausal transition, characterized by a decline in estrogen levels, may affect cholesterol metabolism and ...
Michelle M. Dunk, Ljerka Delac, Stephen R. Rapp, Ira Driscoll, Maria Latorre-Leal, Leslie V. Farland, Bernhard Haring, Holly R. Harris, Su Yon Jung, JoAnn E. Manson, Heather M. Ochs-Balcom, Aladdin H. Shadyab, Julie C. Weitlauf, Hong Xu, Eric Westman, Silvia Maioli   +15 more
doaj   +1 more source

The controversial role of 24S-hydroxycholesterol in Alzheimer's disease

Free Radical Biology and Medicine, 2023
Gamba, Paola, Testa, Gabriella, Giannelli, Serena, Staurenghi, Erica, Sottero, Barbara, Poli, Giuseppe, Leonarduzzi, Gabriella   +6 more
openaire   +2 more sources

The Influence of Dietary Cholesterol on 26-Hydroxycholesterol and the Effect of 26-Hydroxycholesterol on the Intracellular Free Calcium Level

, 1987
Oxidized derivatives of cholesterol, such as 26-hydroxycholesterol are an enzymatic oxidation product of cholesterol, which have been studied in vivo and in vitro systems.
Kou, I-Ling
core  

A Concise Synthesis of 25-Hydroxycholesterol from Hyodesoxycholic Acid

, 2018
A simple, efficient and economical method has been developed for the synthesis of 25-hydroxycholesterol in seven steps from hyodesoxycholic acid with an overall yield of 39%.
Yulei Wang, Bin Sun, Weike Su, Can Jin
core   +1 more source

The Impact of Brain Cholesterol (24-hydroxycholesterol (24-HC) and 27- hydroxycholesterol (27-HC)) on Invitro Phenotypes of Brain Metastatic Breast Cancer Cells

Introduction: Brain metastases is one of the leading causes of breast cancer mortality and rates continue to increase. It has been previously shown that cholesterol metabolism is an important regulator of cancer progression.
Iroabuchi, Cherish
core   +1 more source

Investigating the Effect of 17β-Estradiol on 24(S)-hydroxycholesterol Concentration in Brain Tissue

, 2021
Estrogen, more specifically 17β-estradiol (E2), has been found to have neuroprotective effects in the brain. With Alzheimer's patients being comprised mainly of women, it is worthwhile to investigate the role that reproductive senescence plays in ...
Oaxaca, K. Celeste
core  

Focus on the controversial Role of 24-hydroxycholesterol in Alzheimer's disease

Free Radical Biology and Medicine, 2022
Gamba, Paola, Testa, Gabriella, Staurenghi, Erica, Giannelli, Serena, Sottero, Barbara, Poli, Giuseppe, Leonarduzzi, Gabriella   +6 more
openaire   +2 more sources

Increased 27-hydroxycholesterol Plasma Level In Men With Low High Density Lipoprotein-cholesterol May Circumvent Their Reduced Cell Cholesterol Efflux Rate.

, 2015
HDL is considered the most important mechanism for the excretion of intracellular cholesterol. The liver is the only organ capable to metabolize cholesterol into bile acid.
Parra, Eliane S, de Faria, Eliana C, Quintão, Eder C R, Zago, Vanessa S, da Silva, Eliton J, Cazita, Patrícia M, Nakandakare, Edna R, Panzoldo, Natália B, Leança, Camila C, Nunes, Valéria S   +9 more
core   +1 more source