Results 131 to 140 of about 13,032 (223)

Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke

Stroke
BACKGROUND: For several decades, it has been recognized that overactivation of the glutamate-gated N-methyl-D-aspartate receptors (NMDARs) and subsequent Ca 2+ toxicity play a critical role in ischemic brain injury.
Huawei Sun, Tao Yang, Roger P. Simon, Zhi-gang Xiong, Tiandong Leng   +4 more
openaire   +3 more sources

Relevance of 24S-hydroxycholesterol as a biomarker of optic neuropathies

, 2010
Purpose: 24S-Hydroxycholesterol is formed by enzymatic oxidation of cholesterol via cholesterol-24S-hydroxylase (CYP46A1) activity in neurons, including retinal ganglion cells and neurons from the inner retina. We investigated whether neurodegeneration could be associated with the release of 24S-hydroxycholesterol in acute neuropathies, and therefore ...
Brétillon, Lionel, Martine, Lucy, Pasquis, Bruno, Fourgeux, Cynthia, Schnebelen, Coralie, Acar, Niyazi, Bjorkhem, Ingemar, Bron, Alain, Creuzot Garcher, Catherine   +8 more
openaire   +2 more sources

Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. [PDF]

J Alzheimers Dis, 2016
Wang HL, Wang YY, Liu XG, Kuo SH, Liu N, Song QY, Wang MW.   +6 more
europepmc   +1 more source

Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer's disease-like pathology in mice. [PDF]

Nat Commun
Li Y, Wang H, Zhang D, Wang S, Li Z, Li J, Tai S, Tong D, Wang B, Lu D, Yuan S, Sun W, Yang B, Bai C, Wang Q, Ding J, Wang Z, Gao Y, Yu H, Cui K, Liu C, Mao J, Yao Y, Liu F, Wan Y, Yuan J, Liu X, Zheng J.   +27 more
europepmc   +1 more source

Focus on the controversial Role of 24-hydroxycholesterol in Alzheimer's disease

Free Radical Biology and Medicine, 2022
Gamba, Paola, Testa, Gabriella, Staurenghi, Erica, Giannelli, Serena, Sottero, Barbara, Poli, Giuseppe, Leonarduzzi, Gabriella   +6 more
openaire   +2 more sources

27-Hydroxycholesterol in bile duct tissue promotes cholangiocarcinoma progression through estrogen receptor signaling. [PDF]

Am J Cancer Res
Konishi N, Miyazaki T, Shimoda M, Morishita Y, Honda A, Ikegami T, Suzuki S.   +6 more
europepmc   +1 more source

Hypertension in Overweight and Obesity: Sex-Specific Role of 4β-Hydroxycholesterol. [PDF]

J Am Heart Assoc
Rahunen R, Merikallio H, Rinne V, Savolainen MJ, Hukkanen J.   +4 more
europepmc   +1 more source

Immune Modulatory Oxysterols Produced from Cholesterol-Containing Lipid Nanoparticles Regulate Tumor Growth. [PDF]

ACS Nano
Back PI, Modaresahmadi S, Patel J, Subramaniyan I, Edpuganti V, Islam MR, Chowdhury S, Carr AJ, Zhang Q, Putnam WC, Li L, La-Beck NM.   +11 more
europepmc   +1 more source

Statins for the treatment of dementia [PDF]

, 2010
Bullock, Roger, Craig, David, Malouf, Reem, McGuinness, Bernadette, O'Hare, John, Passmore, Peter   +5 more
core   +1 more source

Efavirenz treatment improves retinal vaso-obliteration and pathological neovascularization in a mouse model of retinopathy of prematurity. [PDF]

Front Med (Lausanne)
Bailey B, Rudd Zhong Manis J, Seth G, Rajpurohit S, Oxenrider A, Martin PM, Jadeja RN, Thounaojam MC.   +7 more
europepmc   +1 more source