Results 121 to 130 of about 13,032 (223)
The Role of Oxysterol Binding Proteins in Macrophages [PDF]
, 2012 Biological membranes consist of several types of lipids that have important structural and functional roles. Moreover, these lipids can act as signaling molecules or affect the function of cellular proteins.
Vihervaara, Terhi
core
Journal of Lipid ResearchFragile X syndrome (FXS) is caused by mutations in the fragile X mental retardation 1 gene, characterized by low plasma cholesterol levels. Considering the essential role of brain cholesterol in signaling and synaptogenesis, it is important to screen for
Asma Laroui +11 more
doaj +1 more source
Journal of Lipid Research, 1996 We have defined the lipid composition of copper-oxidized LDL (Cu-oxLDL) and a macrophage-foam cell model generated by the uptake of this modified lipoprotein.
A J Brown, R T Dean, W Jessup
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Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry [PDF]
, 2018 The potential use of cholesterol esterases was tested to avoid alkaline hydrolysis for cleavage of plasma esterified oxysterols. The enzymatic hydrolysis was optimized by testing two sources of enzyme—Pseudomonas and bovine pancreas, presence of ...
Domeño, Celia +5 more
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Journal of Lipid ResearchWomen face a higher lifetime risk of developing neurodegenerative diseases such as Alzheimer’s disease and related dementias. The menopausal transition, characterized by a decline in estrogen levels, may affect cholesterol metabolism and ...
Michelle M. Dunk +15 more
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, 2010 Multinuclear solid state MAS NMR (1H and 31P), 31P CSA solid state NMR, 2H NMR and x-ray diffraction techniques have been used to compare the structure and properties of DPPC: Andro and DPPC: 4β-hydroxycholesterol with that of the properties known of ...
Trevenen, Alexandra H +1 more
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The controversial role of 24S-hydroxycholesterol in Alzheimer's disease
Free Radical Biology and Medicine, 2023 Gamba, Paola +6 more
openaire +2 more sources
24S-Hydroxycholesterol: A potential brain-derived biomarker of Huntington’s Disease
Abstract Huntington’s disease (HD) arises from of an expanded polyglutamine-coding trinucleotide repeat in exon 1 of the huntingtin gene. Despite considerable research, a successful disease modifying therapy has yet to be confirmed. Cholesterol homeostasis in brain is considered one of the biological processes to be disturbed in HD.
Mohsen Ali Asgari +5 more
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Neurobiology of DiseaseMultiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme ...
Serena Giannelli +10 more
doaj +1 more source