Results 11 to 20 of about 13,032 (223)

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A) [PDF]

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +3 more sources

24S‐hydroxycholesterol: cellular effects and variations in brain diseases [PDF]

Journal of Neurochemistry, 2020
The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or 24-cholesterol hydroxylase, that ...
Boussicault L., Bretillon L., Camargo N., Djelti F., Fellows Maxwell K., Freemantle E., Gambert S., Horton J. D., Huber M., Hughes T. M., Kotti T., Kraats C., Kölsch H., Locatelli S., Lütjohann D., Okabe A., Saint‐Pol J., Ullrich C., Valenza M., Wang Y.   +19 more
core   +6 more sources

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. [PDF]

Proc Natl Acad Sci U S A, 2016
Significance Oxysterols promote tumor growth directly or through the dampening of tumor-infiltrating immune cells. Whether oxysterols contribute to pancreatic neuroendocrine tumor (pNET) development and how they are generated within the pNET microenvironment are currently unknown.
Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, Raccosta L, Lin CY, Invernizzi F, Crocchiolo R, Doglioni C, Traversari C, Bachi A, Bernardi R, Bordignon C, Gustafsson JÅ, Russo V.   +16 more
europepmc   +5 more sources

Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia [PDF]

npj Schizophrenia, 2020
AbstractPlasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain structures, 24S-hydroxycholesterol is a promising biomarker for psychiatric and neurologic disorders that impact brain structure.
Joshua Chiappelli, Maria S. Quinton, Dmitri Volfson, Michael Cwik, Wyatt Marshall, Heather Bruce, Eric Goldwaser, Mark Kvarta, Ann Summerfelt, Peter Kochunov, Patricio O’Donnell, Liyi Elliot Hong   +11 more
openaire   +2 more sources

Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques

Diabetes & Vascular Disease Research, 2022
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells.
Raphael S Pinto, Guilherme S Ferreira, Gina Camillo R Silvestre, Monique de Fátima M Santana, Valéria S Nunes, Lucas Ledesma, Paula R Pinto, Sayonara Ivana S de Assis, Ubiratan F Machado, Erasmo S da Silva, Marisa Passarelli   +10 more
doaj   +1 more source

Identification of Novel Regulatory Cholesterol Metabolite, 5-Cholesten, 3β,25-Diol, Disulfate [PDF]

, 2014
Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of ...
Kakiyama, Genta, Kim, Jin Koung, Min, Hae-Ki, Ning, Yanxia, Pandak, William M., Ren, Shunlin, Rodriguez-Agudo, Daniel   +6 more
core   +6 more sources

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

, 2019
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Failing, Klaus, Hamid, Penny, Hermosilla, Carlos, Kerner, Katharina, Larrazabal, Camilo, Lütjohann, Dieter, Silva, Liliana M. R., Taubert, Anja, Velasquez, Zahady D.   +8 more
core   +2 more sources

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression [PDF]

Neurobiology of Disease, 2013
24S-hydroxycholesterol (24OHC) is involved in the conversion of excess cholesterol in the brain, and its level in plasma is related to the number of metabolically active neuronal cells. Previous research suggests that plasma 24OHC is substantially reduced in the presence of neurodegenerative disease.
Leoni, V, Long, JD, Mills, JA, Di Donato, S, Paulsen, JS   +4 more
openaire   +4 more sources

Comparison of Cholesterol Lowering Diets: Apple, Casein Cytochrom P450 protein and Cholesterol 7α Hydroxylase Activities in Hamsters [PDF]

, 2010
Lithogenic diet, casein and apple fiber diets were fed to hamsters for 3-5 weeks. For control group, animals were fed on normal Purina chow without any supplement.
Rakesh Sharma, Rakesh K. Tandon
core   +2 more sources

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

Frontiers in Immunology, 2022
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis ...
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon   +6 more
doaj   +1 more source