Results 11 to 20 of about 2,904,339 (217)

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. [PDF]

Proc Natl Acad Sci U S A, 2016
Significance Oxysterols promote tumor growth directly or through the dampening of tumor-infiltrating immune cells. Whether oxysterols contribute to pancreatic neuroendocrine tumor (pNET) development and how they are generated within the pNET microenvironment are currently unknown.
Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, Raccosta L, Lin CY, Invernizzi F, Crocchiolo R, Doglioni C, Traversari C, Bachi A, Bernardi R, Bordignon C, Gustafsson JÅ, Russo V.   +16 more
europepmc   +6 more sources

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A) [PDF]

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +3 more sources

Plasma oxysterols: Altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder

The Journal of Steroid Biochemistry and Molecular Biology, 2021
Cholesterol and its oxygenated metabolites, including oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorders. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders.
Guidara, Wassim, Messedi, Meriam, Maalej, Manel, Naifar, Manel, Khrouf, Walid, Grayaa, Sahar, Maalej, Mohamed, Bonnefont-Rousselot, Dominique, Lamari, Foudil, Ayadi, Fatma   +9 more
openaire   +4 more sources

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

Neuroscience Letters, 2000
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance.
Brétillon, Lionel, Siden, A., Wahlund, L.O., Lütjohann, D., Minthon, L., Crisby, M., Hillert, J., Groth, C.G., Diczfalusy, U., Bjorkhem, Ingemar   +9 more
openaire   +4 more sources

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells [PDF]

Molecular Neurodegeneration, 2009
Background Activation of the liver × receptors (LXRs) by exogenous ligands stimulates the degradation of β-amyloid 1–42 (Aβ42), a peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD).
Schommer Eric, Thompson Alex, Thomasson Sarah, Huls Amber, Prasanthi Jaya RP, Ghribi Othman   +5 more
doaj   +2 more sources

Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
Although two hepatic sterol metabolites, 24(S)-hydroxycholesterol and 24(S),25-epoxycholesterol, are thought to be important regulators of cholesterol biosynthesis, nothing is known of their degradation and disposal in liver, nor of the mechanisms that regulate their levels.
Saucier, S E, Kandutsch, A A, Clark, D S, Spencer, T A   +3 more
openaire   +3 more sources

Associations between plasma 24(S)-hydroxycholesterol and neuropsychological profile in fragile X syndrome

Journal of Lipid Research
Fragile X syndrome (FXS) is caused by mutations in the fragile X mental retardation 1 gene, characterized by low plasma cholesterol levels. Considering the essential role of brain cholesterol in signaling and synaptogenesis, it is important to screen for
Asma Laroui, Daniela Rojas, Sophie Bouhour, Mélodie Proteau-Lemieux, Luc Galarneau, Sérine Benachenhou, Armita Abolghasemi, Rosalie Plantefeve, Pierre-Luc Mallet, François Corbin, Jean-François Lepage, Artuela Çaku   +11 more
doaj   +2 more sources

Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3

Scientific Reports, 2023
A growing body of evidence suggests that oxysterols such as 25-hydroxycholesterol (25HC) are biologically active and involved in many physiological and pathological processes.
Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan   +9 more
doaj   +2 more sources

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Neurobiology of Disease
Multiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme ...
Serena Giannelli, Francesca Eroli, Raúl Loera-Valencia, Valerio Leoni, Maria Latorre-Leal, Gabriella Testa, Erica Staurenghi, Barbara Sottero, Paola Gamba, Silvia Maioli, Gabriella Leonarduzzi   +10 more
doaj   +2 more sources

Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus

Neurobiology of Disease, 2021
The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is of major importance.Changes of brain cholesterol homeostasis is an emerging candidate for excitotoxicity.
Aurélie Hanin, Paul Baudin, Sophie Demeret, Delphine Roussel, Sarah Lecas, Elisa Teyssou, Maria Damiano, David Luis, Virginie Lambrecq, Valerio Frazzini, Maxens Decavèle, Isabelle Plu, Dominique Bonnefont-Rousselot, Randa Bittar, Foudil Lamari, Vincent Navarro   +15 more
doaj   +1 more source