Results 11 to 20 of about 4,101,858 (162)

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells [PDF]

Molecular Neurodegeneration, 2009
Background Activation of the liver × receptors (LXRs) by exogenous ligands stimulates the degradation of β-amyloid 1–42 (Aβ42), a peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD).
Schommer Eric, Thompson Alex, Thomasson Sarah, Huls Amber, Prasanthi Jaya RP, Ghribi Othman   +5 more
doaj   +2 more sources

Associations between plasma 24(S)-hydroxycholesterol and neuropsychological profile in fragile X syndrome

Journal of Lipid Research
Fragile X syndrome (FXS) is caused by mutations in the fragile X mental retardation 1 gene, characterized by low plasma cholesterol levels. Considering the essential role of brain cholesterol in signaling and synaptogenesis, it is important to screen for
Asma Laroui, Daniela Rojas, Sophie Bouhour, Mélodie Proteau-Lemieux, Luc Galarneau, Sérine Benachenhou, Armita Abolghasemi, Rosalie Plantefeve, Pierre-Luc Mallet, François Corbin, Jean-François Lepage, Artuela Çaku   +11 more
doaj   +2 more sources

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Neurobiology of Disease
Multiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme ...
Serena Giannelli, Francesca Eroli, Raúl Loera-Valencia, Valerio Leoni, Maria Latorre-Leal, Gabriella Testa, Erica Staurenghi, Barbara Sottero, Paola Gamba, Silvia Maioli, Gabriella Leonarduzzi   +10 more
doaj   +2 more sources

Brain-Specific Oxysterols and Risk of Schizophrenia in Clinical High-Risk Subjects and Patients With Schizophrenia

Frontiers in Psychiatry, 2021
Accumulating evidence from clinical, genetic, and epidemiologic studies suggest that schizophrenia might be a neuronal development disorder. While oxysterols are important factors in neurodevelopment, it is unknown whether oxysterols might be involved in
Zuoli Sun, Lei Zhao, Qijing Bo, Zhen Mao, Yi He, Tao Jiang, Yuhong Li, Yuhong Li, Chuanyue Wang, Chuanyue Wang, Rena Li, Rena Li   +11 more
doaj   +1 more source

Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus

Neurobiology of Disease, 2021
The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is of major importance.Changes of brain cholesterol homeostasis is an emerging candidate for excitotoxicity.
Aurélie Hanin, Paul Baudin, Sophie Demeret, Delphine Roussel, Sarah Lecas, Elisa Teyssou, Maria Damiano, David Luis, Virginie Lambrecq, Valerio Frazzini, Maxens Decavèle, Isabelle Plu, Dominique Bonnefont-Rousselot, Randa Bittar, Foudil Lamari, Vincent Navarro   +15 more
doaj   +1 more source

Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques

Diabetes & Vascular Disease Research, 2022
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells.
Raphael S Pinto, Guilherme S Ferreira, Gina Camillo R Silvestre, Monique de Fátima M Santana, Valéria S Nunes, Lucas Ledesma, Paula R Pinto, Sayonara Ivana S de Assis, Ubiratan F Machado, Erasmo S da Silva, Marisa Passarelli   +10 more
doaj   +1 more source

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. [PDF]

Proc Natl Acad Sci U S A, 2016
Cells in the tumor microenvironment may be reprogrammed by tumor-derived metabolites. Cholesterol-oxidized products, namely oxysterols, have been shown to favor tumor growth directly by promoting tumor cell growth and indirectly by dampening antitumor ...
Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, Raccosta L, Lin CY, Invernizzi F, Crocchiolo R, Doglioni C, Traversari C, Bachi A, Bernardi R, Bordignon C, Gustafsson JÅ, Russo V.   +16 more
europepmc   +2 more sources

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

Frontiers in Immunology, 2022
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis ...
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon   +6 more
doaj   +1 more source

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

Frontiers in Aging Neuroscience, 2021
Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a ...
Irina A. Pikuleva, Nathalie Cartier
doaj   +1 more source