Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study [PDF]
npj Aging and Mechanisms of Disease, 2021 The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the ...
Vijay R. Varma +14 more
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Proprotein Convertase Subtilisin/Kexin Type 9, Brain Cholesterol Homeostasis and Potential Implication for Alzheimer’s Disease [PDF]
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD) has been associated with dysregulation of brain cholesterol homeostasis. Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond the known role in the regulation of plasma low-density lipoprotein cholesterol, was first ...
Maria Pia Adorni +4 more
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Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]
Cell Journal, 2023 Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi +8 more
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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells
Cell Reports, 2023 Summary: Cholesterol is a structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here, we found that glioblastoma (GBM), the most lethal brain tumor, maintains normal levels
Feng Geng +8 more
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Investigating the role of neuroglobin in cholesterol metabolism: a spotlight on brain-derived cells [PDF]
Lipids in Health and DiseaseBackground Cholesterol is a crucial determinant of membrane structure, signaling, and synaptic function in the central nervous system, where its homeostasis is tightly controlled to support neuronal viability and plasticity to prevent neurodegeneration ...
Sara Caputo +6 more
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Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain. [PDF]
PLoS ONE, 2014 Regulative circuits controlling expression of genes involved in the same biological processes are frequently interconnected. These circuits operate to coordinate the expression of multiple genes and also to compensate dysfunctions in specific elements of
Raffaella Picco +3 more
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Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington’s disease [PDF]
Translational NeurodegenerationBackground Huntington’s disease (HD) is a genetically dominant neurodegenerative disorder characterized by several pathological mechanisms, including the disruption of brain cholesterol homeostasis.
Monica Favagrossa +14 more
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Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri +4 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 The pathogenesis of Alzheimer's disease (AD) mainly includes the decrease of neurons and synapses, the deposition of the extracellular β⁃ amyloid protein (Aβ), the formation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) caused by ...
WANG Su⁃su +3 more
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Antioxidants, 2022 The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis.
Erica Staurenghi +7 more
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