Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study [PDF]
npj Aging and Mechanisms of Disease, 2021 The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the ...
Vijay R. Varma +14 more
doaj +9 more sources
Proprotein Convertase Subtilisin/Kexin Type 9, Brain Cholesterol Homeostasis and Potential Implication for Alzheimer’s Disease [PDF]
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD) has been associated with dysregulation of brain cholesterol homeostasis. Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond the known role in the regulation of plasma low-density lipoprotein cholesterol, was first ...
Maria Pia Adorni +4 more
doaj +10 more sources
Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]
Cell Journal, 2023 Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi +8 more
doaj +4 more sources
Brain cholesterol in normal and pathological aging [PDF]
Oléagineux, Corps gras, Lipides, 2011 Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Vanmierlo Tim +2 more
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Assessment of cholesterol homeostasis in the living human brain [PDF]
Science Translational Medicine, 2022 Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily eliminated by metabolic clearance via cytochrome P450 46A1 (CYP46A1).
Ahmed Haider +31 more
exaly +6 more sources
SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells
Cell Reports, 2023 Summary: Cholesterol is a structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here, we found that glioblastoma (GBM), the most lethal brain tumor, maintains normal levels
Feng Geng +8 more
doaj +6 more sources
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 The pathogenesis of Alzheimer's disease (AD) mainly includes the decrease of neurons and synapses, the deposition of the extracellular β⁃ amyloid protein (Aβ), the formation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) caused by ...
WANG Su⁃su +3 more
doaj +2 more sources
Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain. [PDF]
PLoS ONE, 2014 Regulative circuits controlling expression of genes involved in the same biological processes are frequently interconnected. These circuits operate to coordinate the expression of multiple genes and also to compensate dysfunctions in specific elements of
Raffaella Picco +3 more
doaj +5 more sources
Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress [PDF]
Journal of NanobiotechnologyCholesterol plays a crucial role in regulating synaptic membrane fluidity and ion channels. Due to the blood-brain barrier, cholesterol in the brain is primarily self-synthesized by astrocytes.
Lei Tian +12 more
doaj +2 more sources
Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri +4 more
doaj +1 more source