Results 11 to 20 of about 2,266,215 (232)
Altered Cholesterol Homeostasis in Huntington’s Disease
Frontiers in Aging Neuroscience, 2022 Huntington’s disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin’s gene.
Radhia Kacher +10 more
doaj +2 more sources
Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]
J NeurochemCholesterol is a fundamental component of the central nervous system, supporting myelin integrity, synaptic structure, membrane organization, and neuronal signaling.
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc +2 more sources
Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications
Frontiers in Aging Neuroscience, 2021 Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a ...
Irina A. Pikuleva, Nathalie Cartier
doaj +1 more source
Neurobiology of Disease, 2021 The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is of major importance.Changes of brain cholesterol homeostasis is an emerging candidate for excitotoxicity.
Aurélie Hanin +15 more
doaj +1 more source
Balancing cholesterol in the brain: from synthesis to disposal
Exploration of Neuroprotective Therapy, 2022 The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the diet, while the majority is synthesized in the body ...
Lydia Qian +3 more
doaj +1 more source
The effect of oligomeric procyanidins on endothelial function and cholesterol homeostasis [PDF]
, 2012 PhDOligomeric procyanidins (OPC) are naturally occurring dietary substances, which studies suggest can protect against cardiovascular disease. To explore this further a double-blind randomised controlled crossover trial, EPICURE (Evaluation of high ...
Rull, Gurvinder Kaur
core +4 more sources
Advanced Biomedical Research, 2023 Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri +5 more
doaj +1 more source
An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
Communications Biology, 2023 Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons.
Karo Talvio +10 more
doaj +1 more source
Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity. [PDF]
, 2009 BACKGROUND: Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and synthesis of cholesterol, fatty acids,
Craig Mickanin +23 more
core +1 more source
Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
Frontiers in Molecular Neuroscience, 2017 Cholesterol is a critical component of membrane bilayers where it plays key structural and functional roles by regulating the activity of diverse signaling platforms and pathways.
Fabian Arenas +10 more
doaj +1 more source