Results 11 to 20 of about 166,999 (286)

Cholesterol metabolism and homeostasis in the brain [PDF]

Protein & Cell, 2015
Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life. Cholesterol metabolism in brain is independent from that in peripheral tissues due to blood-brain barrier. The content of cholesterol in brain must be accurately maintained in order to keep brain function well.
Zhang, Juan, Liu, Qiang
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Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

Pharmacological Research, 2021
Cholesterol homeostasis is a highly regulated process in human body because of its several functions underlying the biology of cell membranes, the synthesis of all steroid hormones and bile acids and the need of trafficking lipids destined to cell metabolism.
Gliozzi, M., Musolino, V., Bosco, F., Scicchitano, M., Scarano, F., Nucera, S., Zito, M. C., Ruga, S., Carresi, C., Macr(\`i), R., Guarnieri, L., Maiuolo, J., Tavernese, A., Coppoletta, A. R., Nicita, C., Mollace, R., Palma, E., Muscoli, C., Belzung, C., Mollace, V.   +19 more
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ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis

Antioxidants, 2022
The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis.
Erica Staurenghi, Valerio Leoni, Marco Lo Iacono, Barbara Sottero, Gabriella Testa, Serena Giannelli, Gabriella Leonarduzzi, Paola Gamba   +7 more
doaj   +1 more source

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

Frontiers in Aging Neuroscience, 2021
Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a ...
Irina A. Pikuleva, Nathalie Cartier
doaj   +1 more source

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]

, 2020
Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro, Betuing, Sandrine, Caboche, Jocelyne, Carmo-Silva, Sara, Cartier, Nathalie, Conceição, André, Costa, Rafael G, Koppenol, Rebekah, Marcelo, Adriana, Matos, Carlos A, Nunes, Ricardo, Nóbrega, Clévio, Sequeira, Raquel L.   +12 more
core   +1 more source

Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus

Neurobiology of Disease, 2021
The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is of major importance.Changes of brain cholesterol homeostasis is an emerging candidate for excitotoxicity.
Aurélie Hanin, Paul Baudin, Sophie Demeret, Delphine Roussel, Sarah Lecas, Elisa Teyssou, Maria Damiano, David Luis, Virginie Lambrecq, Valerio Frazzini, Maxens Decavèle, Isabelle Plu, Dominique Bonnefont-Rousselot, Randa Bittar, Foudil Lamari, Vincent Navarro   +15 more
doaj   +1 more source

Cholesterol metabolism is altered in Rett syndrome: A study on plasma and primary cultured fibroblasts derived from patients [PDF]

, 2014
Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2) are responsible for the onset of the disease.
Di Tunno, Ilenia, Hayek, Joussef, Pallottini, Valentina, Segatto, Marco, Sticozzi, Claudia, Trapani, Laura, Valacchi, Giuseppe   +6 more
core   +6 more sources

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain [PDF]

Journal of Biological Chemistry, 2014
The presence of the blood-brain barrier (BBB) is critical for cholesterol metabolism in the brain, preventing uptake of lipoprotein-bound cholesterol from the circulation. The metabolic consequences of a leaking BBB for cholesterol metabolism have not been studied previously.
Saeed, A. A., Genove, G., Li, T., Lutjohann, D., Olin, M., Mast, N., Pikuleva, I. A., Crick, P., Wang, Y., Griffiths, W., Betsholtz, C., Bjorkhem, I.   +11 more
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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain [PDF]

Proceedings of the National Academy of Sciences, 1999
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily secreted from the central nervous system into the plasma. To gain molecular insight into this pathway of cholesterol metabolism, we used expression cloning to isolate cDNAs that encode ...
E G, Lund, J M, Guileyardo, D W, Russell
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Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis

Journal of Pharmacy and Pharmacology, 2021
Abstract Objectives Human brain is composed of 25% of the cholesterol & any dysfunction in brain cholesterol homeostasis contributes to neurodegenerative disorders such as Parkinson, Alzheimer’s, Huntington’s disease, etc.
Tanvi Dayanand Pingale, Girdhari Lal Gupta   +1 more
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