Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study [PDF]
npj Aging and Mechanisms of Disease, 2021 The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the ...
Vijay R. Varma +14 more
doaj +10 more sources
Proprotein Convertase Subtilisin/Kexin Type 9, Brain Cholesterol Homeostasis and Potential Implication for Alzheimer’s Disease [PDF]
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD) has been associated with dysregulation of brain cholesterol homeostasis. Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond the known role in the regulation of plasma low-density lipoprotein cholesterol, was first ...
Maria Pia Adorni +4 more
doaj +12 more sources
SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells [PDF]
Cell Reports, 2023 Summary: Cholesterol is a structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here, we found that glioblastoma (GBM), the most lethal brain tumor, maintains normal levels
Feng Geng +8 more
doaj +10 more sources
Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain. [PDF]
PLoS ONE, 2014 Regulative circuits controlling expression of genes involved in the same biological processes are frequently interconnected. These circuits operate to coordinate the expression of multiple genes and also to compensate dysfunctions in specific elements of
Raffaella Picco +3 more
doaj +9 more sources
Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]
Cell Journal, 2023 Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi +8 more
doaj +3 more sources
Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis [PDF]
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2013 Disruption of cholesterol homeostasis in the central nervous system (CNS) has been associated with neurological, neurodegenerative, and neurodevelopmental disorders. The CNS is a closed system with regard to cholesterol homeostasis, as cholesterol-delivering lipoproteins from the periphery cannot pass the blood-brain-barrier and enter the brain ...
Xiaolu Zhang +2 more
exaly +5 more sources
Cholesterol metabolism and homeostasis in the brain [PDF]
Protein and Cell, 2015 Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life. Cholesterol metabolism in brain is independent from that in peripheral tissues due to blood-brain barrier. The content of cholesterol in brain must be accurately maintained in order to keep brain function well.
Qiang Liu
exaly +3 more sources
Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues
Pharmacological Research, 2021 Cholesterol homeostasis is a highly regulated process in human body because of its several functions underlying the biology of cell membranes, the synthesis of all steroid hormones and bile acids and the need of trafficking lipids destined to cell metabolism.
Vincenzo Musolino +2 more
exaly +3 more sources
Altered Cholesterol Homeostasis in Huntington’s Disease
Frontiers in Aging Neuroscience, 2022 Huntington’s disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin’s gene.
Radhia Kacher +10 more
doaj +2 more sources
Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis
Journal of Pharmacy and Pharmacology, 2021 Abstract Objectives Human brain is composed of 25% of the cholesterol & any dysfunction in brain cholesterol homeostasis contributes to neurodegenerative disorders such as Parkinson, Alzheimer’s, Huntington’s disease, etc.
Tanvi Dayanand Pingale +2 more
exaly +3 more sources