Results 41 to 50 of about 166,999 (286)

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. [PDF]

, 2018
A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease and diabetes. Analysis of data from recently published genome-wide association studies
Abad, Janna, Calvert, Meredith E, Chen, Eugene C, Chen, Ligong, Chien, Huan-Chieh, Giacomini, Kathleen M, King, Sarah, Krauss, Ronald M, Liang, Xiaomin, Luo, Qi, Mifune, Arias, Norheim, Frode, Piao, Meiling, Yee, Sook Wah, Zou, Ling   +14 more
core   +3 more sources

Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes [PDF]

, 2018
Huntington disease (HD) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin (htt) protein. Expanded polyQ promotes the formation of a variety
Campbell, Warren A., Chaibva, Maxmore, Frey, Shelli L., Gao, Xiang, Jain, Pranav, Legleiter, Justin   +5 more
core   +4 more sources

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production

Journal of Lipid Research
The mammalian brain is the most cholesterol-rich organ of the body, relying on in situ de novo cholesterol synthesis. Maintaining cholesterol homeostasis is crucial for normal brain function.
Arlette A. Kasongo, Viyashini Vijithakumar, Khaled S. Abd-Elrahman, Radhika Prabhune, Lara Gharibeh, Rachel Nadeau, Isabelle Robillard, Shoshana Spring, Sabrina Robichaud, Shaza Asif, Derrick Gibbings, Kathryn J. Moore, John G. Sled, Matthieu Ruiz, Mathieu Lavallée-Adam, Stephen S.G. Ferguson, Baptiste Lacoste, Diane C. Lagace, Mireille Ouimet   +18 more
doaj   +1 more source

TSPO ligands promote cholesterol efflux and suppress oxidative stress and inflammation in choroidal endothelial cells [PDF]

, 2018
Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE) cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the choroidal blood circulation.
Bartholomew, Christopher, Biswas, Lincoln, Farhan, Fahad, Reilly, James, Shu, Xinhua   +4 more
core   +1 more source

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
Adami, Adams, Adelman, Aguero-Torres, Ahima, Ahren, Akomolafe, Antuna-Puente, Arribas, Arvanitakis, Arvanitakis, Astrup, Bannon, Baran, Barber, Bartus, Barzilai, Baumbach, Baumbach, Baumbach, Behrendt, Bellinger, Berlett, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bjorntorp, Blander, Boden, Bolton, Bordone, Bordone, Brandes, Braun, Bravo, Broughton, Bruce-Keller, Buettner, Bugalho, Bullo, Cai, Calabrese, Calabrese, Calabrese, Calabrese, Calabrese, Carlsson, Carr, Cecarini, Cefalu, Cefalu, Chen, Chen, Chen, Clark, Clayton, Clayton, Comfort, Coon, Coyle, Coyle, Craft, Craft, Curb, Damjanovic, De Feo, de la Torre, Dechenes, DeFronzo, DeFronzo, DeKosky, Desai, Ding, Diniz, Droge, Dunn, d’Alessio, Eckles-Smith, Elahi, Elias, Elias, Elias, Fagot-Campagna, Fantuzzi, Farr, Fassbender, Ferrannini, Ferrannini, Ferrannini, Festa, Finch, Finkel, Franceschi, Freund, Fridlyand, Friedman, Frohman, Frolich, Fruhbeck, Fujimoto, Furukawa, Gabbita, Gabriely, Gazzaley, Gemma, Gibson, Gibson, Giunta, Gold, Gonzalez, Good, Granholm, Gray, Greenwood, Griffin, Gunning-Dixon, Gupta, Guttmann, Haan, Handschin, Harvey, Haslam, Heistad, Heitner, Ho, Hosokawa, Howard, Hoyer, Hsu, Hu, Hultsch, Hynd, Iqbal, Itateyama, Iyo, Izumi, James, Jankowsky, Janson, Jia, Joseph, Juhan-Vague, Kaasinen, Kanoski, Kennedy, Kirwan, Kissebah, Kitani, Klann, Klann, Knapp, Koenig, Kuk, Kumar, Kumari, Kuo, Kuriyama, Kuriyama, Laakso, Lamarche, Langan, Lau, Launer, Lee, Leibson, Leone, Lesser, Li, Lippa, Luchsinger, MacKnight, Magnusson, Maier, Manev, Mantena, Massaad, Matia, Matsuzawa-Nagata, Mattson, Mattson, Mattson, Mattson, McClearn, McNay, McNay, Medawar, Mendall, Meng, Messier, Michikawa, Miller, Miller, Milne, Moller, Moreira, Morin, Morrison, Muckle, Nag, Nagai, Navarro, Newton, Nielsen, Nisoli, Nunomura, Nyberg, Oakes, Ogawa, Oomura, Osmond, Ott, O’Shaughnessy, Pacini, Paolisso, Park, Partridge, Pasinetti, Pasinetti, Patterson, Pedigo, Peila, Peiris, Perlmuter, Perry, Perry, Petrovitch, Pfluger, Picard, Pinteaux, Pistell, Qiu, Qu, Rasouli, Razay, Rinne, Rizza, Rizza, Robertson-Tchabo, Roher, Roman, Rosamond, Rowe, Sattler, Sayre, Scacchi, Scheff, Schmitt-Schillig, Shen, Shi, Shimokata, Smith, Smith, Smith, Sohal, Sonntag, Souza, Spulber, Stadtman, Stadtman, Steemburgo, Steen, Strauss, Svedberg, Tanner, Tariot, Taylor, Terao, Terao, Terry, Tha, Thiels, Thiels, Tohgi, Tschop, Urakawa, Uz, van der Heide, van Exel, Vannucchi, Volkow, Wahrenberg, Wang, Wang, Wang, Ward, Wenk, White, Wieringa, Williams, Winocur, Wong, Woods, Wu, Wu, Xiao, Yaffe, Yasui, Ye, Yudkin, Zhang, Zhao, Zlokovic   +302 more
core   +1 more source

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Journal of Lipid Research, 2008
Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that regulate cholesterol homeostasis, and synthetic LXR agonists decrease neuropathological and ...
Braydon L. Burgess, Pamela F. Parkinson, Margaret M. Racke, Veronica Hirsch-Reinshagen, Jianjia Fan, Charmaine Wong, Sophie Stukas, Louise Theroux, Jeniffer Y. Chan, James Donkin, Anna Wilkinson, Danielle Balik, Brian Christie, Judes Poirier, Dieter Lütjohann, Ronald B. DeMattos, Cheryl L. Wellington   +16 more
doaj   +1 more source

Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?

Antioxidants, 2021
In recent decades, the impairment of cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD) has been intensively investigated, and it has been recognized to affect amyloid β (Aβ) production and clearance, tau phosphorylation ...
Erica Staurenghi, Serena Giannelli, Gabriella Testa, Barbara Sottero, Gabriella Leonarduzzi, Paola Gamba   +5 more
doaj   +1 more source

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes [PDF]

, 2015
Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation.
Bertolini, Camilla, Fallarino, Mara, Filardi, Tiziana, Gianfrilli, Daniele, Giannetta, Elisa, Lenti, Luisa, Lenzi, Andrea, Lococo, Manuela, Mandosi, Elisabetta, Morano, Susanna, Venneri, MARY ANNA   +10 more
core   +1 more source

The Unicellular State as a Point Source in a Quantum Biological System. [PDF]

, 2016
A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific ...
Miller, William B, Torday, John S
core   +6 more sources

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß [PDF]

, 2017
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2) to ...
Bate, C
core   +3 more sources