Results 31 to 40 of about 105,966 (270)
Neurobiology of Disease, 2021 The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is of major importance.Changes of brain cholesterol homeostasis is an emerging candidate for excitotoxicity.
Aurélie Hanin +15 more
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Balancing cholesterol in the brain: from synthesis to disposal
Exploration of Neuroprotective Therapy, 2022 The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the diet, while the majority is synthesized in the body ...
Lydia Qian +3 more
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Advanced Biomedical Research, 2023 Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri +5 more
doaj +1 more source
An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
Communications Biology, 2023 Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons.
Karo Talvio +10 more
doaj +1 more source
Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis
Cell Reports Medicine, 2023 The choroid plexus (CP) plays a key role in remotely controlling brain function in health, aging, and disease. Here, we report that CP epithelial cells express the brain-specific cholesterol 24-hydroxylase (CYP46A1) and that its levels are decreased under different mouse and human brain conditions, including amyloidosis, aging, and SARS-CoV-2 infection.
Tsitsou-Kampeli, Afroditi +15 more
openaire +2 more sources
Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
Frontiers in Molecular Neuroscience, 2017 Cholesterol is a critical component of membrane bilayers where it plays key structural and functional roles by regulating the activity of diverse signaling platforms and pathways.
Fabian Arenas +10 more
doaj +1 more source
Journal of Lipid Research, 2023 The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast +3 more
doaj +1 more source
Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice
eLife, 2016 Previous studies provided evidence for the alteration of brain cholesterol homeostasis in 129.Mecp2-null mice, an experimental model of Rett syndrome. The efficacy of statins in improving motor symptoms and prolonging survival of mutant mice suggested a ...
Claudia Villani +6 more
doaj +1 more source
Journal of Lipid Research, 2000 We have previously presented evidence that most of the 24S-hydroxycholesterol present in the circulation originates from the brain and that most of the elimination of this oxysterol occurs in the liver.
Lionel Bretillon +7 more
doaj +1 more source
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
Disease Models & Mechanisms, 2012 Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic neurodegenerative disorders, including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and ...
Jean E. Vance
doaj +1 more source