Results 31 to 40 of about 2,266,215 (232)

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production

Journal of Lipid Research
The mammalian brain is the most cholesterol-rich organ of the body, relying on in situ de novo cholesterol synthesis. Maintaining cholesterol homeostasis is crucial for normal brain function.
Arlette A. Kasongo, Viyashini Vijithakumar, Khaled S. Abd-Elrahman, Radhika Prabhune, Lara Gharibeh, Rachel Nadeau, Isabelle Robillard, Shoshana Spring, Sabrina Robichaud, Shaza Asif, Derrick Gibbings, Kathryn J. Moore, John G. Sled, Matthieu Ruiz, Mathieu Lavallée-Adam, Stephen S.G. Ferguson, Baptiste Lacoste, Diane C. Lagace, Mireille Ouimet   +18 more
doaj   +1 more source

Genetic Variation in FADS Genes and Plasma Cholesterol Levels in 2-Year-Old Infants [PDF]

, 2013
Single nucleotide polymorphisms (SNPs) in genes involved in fatty acid metabolism (FADS1 FADS2 gene cluster) are associated with plasma lipid levels. We aimed to investigate whether these associations are already present early in life and compare the ...
Moltó-Puigmartí Carolina, Penders, J., Ronald P Mensink, Carolina Moltó-Puigmartí (5261441), Jogchum Plat (302633), Thijs Carel, Monique Mommers, Thijs, Carel, Mommers, Monique, Eugène Jansen, Dirkje S Postma, Mensink Ronald P., John Penders (396322), Mommers Monique, Plat, J., Mensink, Ronald P., Koppelman, Gerard H., Standl Marie, Dirkje S. Postma (101740), Joachim Heinrich (60421), Postma, D.S., Jansen, Eugène, Standl, Marie, Moltó-Puigmartí, Carolina, Penders John, Koppelman Gerard H., Heinrich Joachim, Mensink, R.P., Thijs, C., Gerard H. Koppelman (153163), Postma, Dirkje S., Moltó-Puigmarti, C., Plat Jogchum, Carolina Moltó-Puigmartí, Carel Thijs (112720), Postma Dirkje S., Jansen, E., Joachim Heinrich, Marie Standl, Carel Thijs, Heinrich, Joachim, Jogchum Plat, Mommers, M., Standl, M., Monique Mommers (112709), Heinrich, J., Ronald P. Mensink (302629), Koppelman, Gerard H.; id_orcid, John Penders, Eugène Jansen (123572), Marie Standl (163136), Thijs, C.; id_orcid, Plat, Jogchum, Penders, John, Gerard H Koppelman, Koppelman, G.H., Jansen Eugène   +56 more
core   +3 more sources

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Journal of Lipid Research, 2008
Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that regulate cholesterol homeostasis, and synthetic LXR agonists decrease neuropathological and ...
Braydon L. Burgess, Pamela F. Parkinson, Margaret M. Racke, Veronica Hirsch-Reinshagen, Jianjia Fan, Charmaine Wong, Sophie Stukas, Louise Theroux, Jeniffer Y. Chan, James Donkin, Anna Wilkinson, Danielle Balik, Brian Christie, Judes Poirier, Dieter Lütjohann, Ronald B. DeMattos, Cheryl L. Wellington   +16 more
doaj   +1 more source

Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?

Antioxidants, 2021
In recent decades, the impairment of cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD) has been intensively investigated, and it has been recognized to affect amyloid β (Aβ) production and clearance, tau phosphorylation ...
Erica Staurenghi, Serena Giannelli, Gabriella Testa, Barbara Sottero, Gabriella Leonarduzzi, Paola Gamba   +5 more
doaj   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen, Hageman, Jurre, Herrema, H.J., Folkert Kuipers, Hageman, J., Kuipers, Folkert, Herrema, Hilde, Hilde Herrema, Kuipers, Folkert; id_orcid, Groen, A.K., Kuipers, F., Groen, Albert K., Jurre Hageman   +12 more
core   +1 more source

Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue [PDF]

, 2011
Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations.
Elke Maier, Fortsch, C., Mitchell, T.J., Benz, Roland, Ma, Jiangtao, Christina Förtsch, Sabrina Hupp, Jiangtao Ma, Timothy J. Mitchell, Iliev, A. I., Maier, Elke, Förtsch, Christina, Maier, E., Hupp, Sabrina, Asparouh I. Iliev, Hupp, S., Mitchell, Timothy J, Roland Benz, Wippel, C., Benz, R., Ma, J., Wippel, Carolin, Iliev, Asparouh I, Carolin Wippel   +23 more
core   +1 more source

Isoprenoidquantifizierung in Hirngewebe - cerebrale Regulation von FPP und GGPP bei Morbus Alzheimer und im Alter [PDF]

, 2011
Over the last years there has been an increasing interest in the involvement of the MVA-pathway and of members of the small GTPases, in the development and progression of AD.
Hooff, Gero P.
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

ACAT1, Cav-1, and PrP expression in brains and skin fibroblasts from Sarda breed sheep with scrapie-resistant and scrapie-susceptible genotype. [PDF]

, 2007
Scrapie is an infective ovine neurodegenerative disease; the only identified component of the infectious agent being an aberrant isoform (PrPSc) of the cellular prion protein (PrPC). So far, no means for ante-mortem diagnosis are available for Scrapie as
Claudia Abete, Claudia Mulas, Marirosa Putzolu, Cristina D. Orrù, Sandra Dessì, Alessandra Pani, Paolo La Colla, Sergio Laconi, Claudia Norfo, M. Dolores Cannas   +9 more
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source