Results 21 to 30 of about 166,999 (286)
Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013 Disruption of cholesterol homeostasis in the central nervous system (CNS) has been associated with neurological, neurodegenerative, and neurodevelopmental disorders. The CNS is a closed system with regard to cholesterol homeostasis, as cholesterol-delivering lipoproteins from the periphery cannot pass the blood-brain-barrier and enter the brain ...
Chen, Jing +4 more
openaire +3 more sources
Balancing cholesterol in the brain: from synthesis to disposal
Exploration of Neuroprotective Therapy, 2022 The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the diet, while the majority is synthesized in the body ...
Lydia Qian +3 more
doaj +1 more source
Adropin: An endocrine link between the biological clock and cholesterol homeostasis [PDF]
, 2018 This article explores two translation models circling around the key issue “equivalence” in translation studies. They are the Jerome Model and the Horace Model. They differentiate from each other in the aspects of the translating priorities and purposes,
et al,, Rao, D. C
core +4 more sources
Advanced Biomedical Research, 2023 Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri +5 more
doaj +1 more source
Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis
Cell Reports Medicine, 2023 The choroid plexus (CP) plays a key role in remotely controlling brain function in health, aging, and disease. Here, we report that CP epithelial cells express the brain-specific cholesterol 24-hydroxylase (CYP46A1) and that its levels are decreased under different mouse and human brain conditions, including amyloidosis, aging, and SARS-CoV-2 infection.
Tsitsou-Kampeli, Afroditi +15 more
openaire +2 more sources
An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
Communications Biology, 2023 Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons.
Karo Talvio +10 more
doaj +1 more source
A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
core +8 more sources
Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
Frontiers in Molecular Neuroscience, 2017 Cholesterol is a critical component of membrane bilayers where it plays key structural and functional roles by regulating the activity of diverse signaling platforms and pathways.
Fabian Arenas +10 more
doaj +1 more source
Journal of Lipid Research, 2023 The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol.
Natalia Mast +3 more
doaj +1 more source
Altered Cholesterol Homeostasis in Huntington’s Disease
Frontiers in Aging Neuroscience, 2022 Huntington’s disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin’s gene.
Radhia Kacher +10 more
doaj +1 more source