Brain cholesterol in normal and pathological aging [PDF]
Oléagineux, Corps gras, Lipides, 2011 Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Vanmierlo Tim +2 more
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ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis [PDF]
Antioxidants, 2022 The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis.
Erica Staurenghi +7 more
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Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain [PDF]
Journal of Biological Chemistry, 2014 The presence of the blood-brain barrier (BBB) is critical for cholesterol metabolism in the brain, preventing uptake of lipoprotein-bound cholesterol from the circulation. The metabolic consequences of a leaking BBB for cholesterol metabolism have not been studied previously.
Saeed, A. A. +11 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 The pathogenesis of Alzheimer's disease (AD) mainly includes the decrease of neurons and synapses, the deposition of the extracellular β⁃ amyloid protein (Aβ), the formation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) caused by ...
WANG Su⁃su +3 more
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Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome [PDF]
International Journal of Molecular Sciences, 2019 The mevalonate (MVA)/cholesterol pathway is crucial for central nervous system (CNS) development and function and consequently, any dysfunction of this fundamental metabolic pathway is likely to provoke pathologic changes in the brain. Mutations in genes directly involved in MVA/cholesterol metabolism cause a range of diseases, many of which present ...
Marco Segatto +2 more
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Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress [PDF]
Journal of NanobiotechnologyCholesterol plays a crucial role in regulating synaptic membrane fluidity and ion channels. Due to the blood-brain barrier, cholesterol in the brain is primarily self-synthesized by astrocytes.
Lei Tian +12 more
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Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear.
Zahra Nazeri +4 more
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SHORT-TERM DIABETES IN THE BRAIN: EFFECTS ON NEUROACTIVE STEROIDS, CHOLESTEROL HOMEOSTASIS, AND MITOCHONDRIAL FUNCTIONALITY [PDF]
, 2017 Diabetes may induce neurophysiological and structural changes in the central nervous system (i.e., diabetic encephalopathy). Neuroactive steroids (i.e. molecules derived from cholesterol which exert their actions in the nervous system directly or after metabolization) are key regulators of the central nervous system and are affected in several ...
S. Romano
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Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications
Frontiers in Aging Neuroscience, 2021 Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a ...
Irina A. Pikuleva, Nathalie Cartier
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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain [PDF]
Proceedings of the National Academy of Sciences, 1999 The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily secreted from the central nervous system into the plasma. To gain molecular insight into this pathway of cholesterol metabolism, we used expression cloning to isolate cDNAs that encode ...
E G, Lund, J M, Guileyardo, D W, Russell
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