Results 11 to 20 of about 1,842,116 (207)
27-Hydroxycholesterol in cancer development and drug resistance [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry27-Hydroxycholesterol (27HC), a cholesterol metabolite, functions both as a selective oestrogen receptor (ER) modulator and a ligand for liver X receptors (LXRs).
Yaxin Hou +5 more
doaj +5 more sources
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain [PDF]
Journal of Lipid Research, 2005 Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugular ...
Steve Meaney +2 more
exaly +5 more sources
Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link. [PDF]
Int J Mol Sci, 2020 Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese. Obesity is an important risk factor for several disorders including cardiovascular disease, the first cause of death in the United States.
Asghari A, Umetani M.
europepmc +5 more sources
Pathophysiological role of 27-hydroxycholesterol in human diseases
Advances in Biological Regulation, 2022 Oxysterols are oxygenated cholesterol derivatives and important regulators of cholesterol metabolism, lipid homeostasis, the immune system, and membrane fluidity regulation. Although the detailed mechanism of action of oxysterols remains unclear, activation of some nuclear receptors, such as liver X receptor α (LXRα) and RAR-related orphan receptors ...
Dayea Kim +7 more
openaire +4 more sources
Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness [PDF]
Scientific Reports, 2019 AbstractCholesterol mediates its proliferative and metastatic effects via the metabolite 27-hydroxycholesterol (27-HC), at least in breast and endometrial cancer. We determined the serum lipoprotein profile, intratumoral cholesterol and 27-HC levels in a cohort of patients with well-differentiated papillary thyroid carcinoma (PTC; low/intermediate and ...
Giovanna Revilla +18 more
openaire +6 more sources
Redox Biology, 2020 There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Alessandro Marcello +2 more
exaly +3 more sources
PLoS ONE, 2014 High plasma levels of cholesterol have been suggested to be neuroprotective for the degenerative disease amyotrophic lateral sclerosis (ALS) and to be associated with increased survival time.
Anna Wuolikainen +6 more
doaj +2 more sources
27-Hydroxycholesterol: production rates in normal human subjects [PDF]
Journal of Lipid Research, 1999 We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj +3 more sources
Paroxetine suppresses 27-hydroxycholesterol-induced responses in THP-1 human monocytic cells by regulating the AKT/mTORC1 pathway [PDF]
Scientific ReportsParoxetine (PRX) is widely prescribed for treating psychiatric disorders. Emerging evidence suggests that PRX can act as an immunosuppressive agent, yet the molecular mechanisms underlying its effects are not fully understood. This study has investigated
Dongha Park +3 more
doaj +2 more sources
Connecting the Dots Between Hypercholesterolemia and Alzheimer’s Disease: A Potential Mechanism Based on 27-Hydroxycholesterol [PDF]
Frontiers in Neuroscience, 2022 Alzheimer’s disease (AD), the most common cause of dementia, is a complex and multifactorial disease involving genetic and environmental factors, with hypercholesterolemia considered as one of the risk factors.
Mingan Wu +29 more
doaj +2 more sources