Results 11 to 20 of about 2,669,160 (149)
PLoS ONE, 2014 High plasma levels of cholesterol have been suggested to be neuroprotective for the degenerative disease amyotrophic lateral sclerosis (ALS) and to be associated with increased survival time.
Anna Wuolikainen +6 more
doaj +2 more sources
Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol
Redox Biology, 2017 Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action.
Valeria Cagno +9 more
doaj +2 more sources
, 1998 Microsomal cytochrome P450 catalyzing the 7 alpha-hydroxylation of 27-hydroxycholesterol and dehydroepiandrosterone was partially purified from pig liver.
Norlin, M,, Wikvall, K,
core +8 more sources
Inhibition of Marek's Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro. [PDF]
Viruses, 2023 Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Kamble N +6 more
europepmc +2 more sources
Regulation of Th17/Treg Balance by 27-Hydroxycholesterol and 24S-Hydroxycholesterol Correlates with Learning and Memory Ability in Mice. [PDF]
Int J Mol Sci, 2022 Dysregulation of cholesterol metabolism and its oxidative products—oxysterols—in the brain is known to be associated with neurodegenerative diseases.
Wang T +8 more
europepmc +2 more sources
, 2021 Miconazole is effective in treating inflammatory skin conditions and has well-established antifungal effects. To elucidate the underlying mechanisms mediating its additional beneficial effects, we assessed whether miconazole influences the inflammation ...
Seong-Kug Eo (3850609) +5 more
core +1 more source
Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption [PDF]
, 2011 In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core +1 more source
27-Hydroxycholesterol: production rates in normal human subjects
Journal of Lipid Research, 1999 We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj +1 more source
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
Journal of Lipid Research, 2005 Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugular ...
Maura Heverin +5 more
doaj +1 more source
Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes.
Journal of Lipid Research, 1993 The use of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for solubilizing cholesterol and 27-hydroxycholesterol has led to a study of their rates of 7 alpha-hydroxylation in microsomal preparations from hamster liver and HepG2 cells.
KO Martin, K Budai, NB Javitt
doaj +1 more source