Results 21 to 30 of about 1,842,116 (207)

Sex difference in flux of 27-hydroxycholesterol into the brain. [PDF]

Br J Pharmacol, 2021
Background and PurposeThe cerebrospinal fluid (CSF)/plasma albumin ratio (QAlb) is believed to reflect the integrity of the blood–brain barrier (BBB). Recently, we reported that QAlb is lower in females. This may be important for uptake of neurotoxic 27‐hydroxycholesterol (27OH) by the brain in particular because plasma levels of 27OH are higher in ...
Parrado-Fernandez C, Leoni V, Saeed A, Rodriguez-Rodriguez P, Sandebring-Matton A, Córdoba-Beldad CM, Bueno P, Gali CC, Panzenboeck U, Cedazo-Minguez A, Björkhem I.   +10 more
europepmc   +7 more sources

Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol [PDF]

Experimental and Therapeutic Medicine, 2010
The aim of the present study was to identify the possible mechanisms by which certain estradiol receptor (ER)-positive mammary tumor cells remain resistant to treatment with anti-estrogens or inhibitors of local estradiol (E(2)) production. To this end, we compared the proliferative effects on mammary cancer cells of the novel selective ER modulator 27-
Cruz, Pamela, Torres, Cristian, Ramírez, María Eugenia, Epuñán, María José, Valladares Boasi, Luis, Sierralta, Walter Daniel   +5 more
openaire   +7 more sources

Inhibition of Marek's Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro. [PDF]

Viruses, 2023
Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Kamble N, Reddy VRAP, Jackson B, Anjum FR, Ubachukwu CC, Patil A, Behboudi S.   +6 more
europepmc   +2 more sources

The role of 27-hydroxycholesterol in meta-inflammation. [PDF]

Korean J Physiol Pharmacol
27-Hydroxycholesterol (27OHChol), a prominent cholesterol metabolite present in the bloodstream and peripheral tissues, is a kind of immune oxysterol that elicits immune response. Recent research indicates the involvement of 27OHChol in metabolic inflammation (meta-inflammation) characterized by chronic responses associated with metabolic ...
Son Y, Choi E, Hwang Y, Kim K.
europepmc   +3 more sources

Deciphering the role of 27-hydroxycholesterol in neurodegeneration

, 2016
Cholesterol is constantly attributed to neurodegenerative diseases including Alzheimer’s disease (AD). This is due to the association of high blood cholesterol and the consequences of cholesterol metabolism in these conditions. However the brain isolates itself from the peripheral cholesterol with the use of its impervious barrier, therefore how does ...
Muhammad Ismail (18637081)
openaire   +2 more sources

The Cytotoxicity of 27-Hydroxycholesterol in MCF-7 and MDA-MB-231. [PDF]

Adv Biomed Res, 2023
Abstract Background: Although several roles of 27-hydroxycholesterol (27-HC), the most abundant oxysterol in blood circulation, in cancers have been elucidated, its impact on breast cancer proliferation and its pathway remain unknown.
Rashidi Alavijeh M, Etesami H, Dehghan A, Babajani A, Haghjooy Javanmard S.   +4 more
europepmc   +3 more sources

Regulation of Th17/Treg Balance by 27-Hydroxycholesterol and 24S-Hydroxycholesterol Correlates with Learning and Memory Ability in Mice. [PDF]

Int J Mol Sci, 2022
Dysregulation of cholesterol metabolism and its oxidative products—oxysterols—in the brain is known to be associated with neurodegenerative diseases.
Wang T, Cui S, Cui S, Hao L, Liu W, Wang L, Ju M, Feng W, Xiao R.   +8 more
europepmc   +2 more sources

27-hydroxycholesterol and DNA damage repair: implication in prostate cancer. [PDF]

Front Oncol, 2023
IntroductionWe previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the CYP27A1/27HC axis inhibited PC growth.
Galvan GC, Friedrich NA, Das S, Daniels JP, Pollan S, Dambal S, Suzuki R, Sanders SE, You S, Tanaka H, Lee YJ, Yuan W, de Bono JS, Vasilevskaya I, Knudsen KE, Freeman MR, Freedland SJ.   +16 more
europepmc   +6 more sources

Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]

Cell Journal, 2023
Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi, Zahra Nazeri, Arash Rafeeinia, Seyedeh Pardis Pezeshki, Alireza Kheirollah, Yaghoob Farbood, Maryam Adelipour, Shirin Azizidoost, Maryam Cheraghzadeh   +8 more
doaj   +1 more source

[Retracted] The oncogenic roles of 27‑hydroxycholesterol in glioblastoma. [PDF]

Oncol Lett
Liu L, Li MY, Xing Y, Wang XY, Wang Y.
europepmc   +2 more sources