Results 1 to 10 of about 4,690 (123)

Different Effects on the Expression of CYP7 and CYP27 in Rabbit Liver by Cholic Acid and Cholestyramine

Biochemical and Biophysical Research Communications, 1995
It was recently reported that both cholesterol 7 alpha-hydroxylase CYP7 and sterol 27-hydroxylase CYP27 are subject to negative feedback control by bile acids in isolated rat hepatocytes and rat liver (Twisk et al., (1995) Biochem. J.
K Wikvall
exaly   +9 more sources

Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27−/− mice and CTX

Journal of Lipid Research, 2001
Cerebrotendinous xanthomatosis (CTX) is a rare, recessively inherited lipid storage disease characterized by a markedly reduced production of chenodeoxycholic acid and an increased formation of 25-hydroxylated bile alcohols and cholestanol. Patients with
Eran Leitersdorf, Akira Honda, Sandra K Erickson   +2 more
exaly   +3 more sources

Tumor-resident Malassezia can promote hepatocellular carcinoma development by downregulating bile acid synthesis and modulating tumor microenvironment [PDF]

Scientific Reports
Bacterial dysbiosis coincides with the carcinogenesis in malignancies such as lung and colon cancer, and has recently been suggested to involve in the pathogenesis of hepatocellular carcinoma (HCC).
Weixi Shen, Zhihong Li, Lei Wang, Qi Liu, Renjie Zhang, Yuhua Yao, Zhicheng Zhao, Lei Ji   +7 more
doaj   +2 more sources

A possible role for CYP27 as a major renal mitochondrial 25-hydroxyvitamin D3 1α-hydroxylase [PDF]

FEBS Letters, 1996
A mitochondrial cytochrome P450 fraction catalyzing 1α- and 27-hydroxylation but not 24-hydroxylation of 25-hydroxyvitamin D3 was purified from pig kidney.
Maria Norlin, H Postlind
exaly   +2 more sources

Differential effects of 17α-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat [PDF]

Journal of Lipid Research, 1999
Effects of 17α-ethinylestradiol (EE) on the neutral and acidic biosynthetic pathways of bile salt (BS) synthesis were evaluated in rats with an intact enterohepatic circulation and in rats with long-term bile diversion to induce BS synthesis.
Nynke R. Koopen, Sabine M. Post, Henk Wolters, Rick Havinga, Frans Stellaard, Renze Boverhof, Folkert Kuipers, Hans M.G. Princen   +7 more
doaj   +3 more sources

Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis

American Journal of Physiology - Renal Physiology, 2001
In the liver, sterol 27-hydroxylase (CYP27) participates in the classic and alternative pathways of bile acid biosynthesis from cholesterol (Chol). In extrahepatic tissues, CYP27 converts intracellular Chol to 27-hydroxycholesterol (27OH-Chol), which may
P. Hylemon, D. Mallonee, E. Hall, W. Pandak, Z. Vlahcevic, K. Valerie, N. Avadhani   +6 more
exaly   +2 more sources

Partial deletion of the gene encoding sterol 27-hydroxylase in a subject with cerebrotendinous xanthomatosis

Journal of Lipid Research, 1996
An Italian subject with cerebrotendinous xanthomatosis (CTX) was found to have a partial deletion of the gene encoding the enzyme sterol 27-hydroxylase (CYP27 gene).
R Garuti, N Lelli, M Barozzini, M T Dotti, A Federico, S Bertolini, S Calandra   +6 more
doaj   +3 more sources

Molecular Biological Mechanisms of Action of Chrysophanol in Hepatic Stellate Cells Activated by Hepatic B Virus X Based on Network Pharmacology

Intervirology
Introduction: Chrysophanol (Cho) is a natural anthraquinone with biological effects such as inducing ferroptosis and anticancer activity. The hepatitis B virus X protein (HBx) is essential for HBV replication.
Chih-Hung Lin, Ching-Feng Cheng, Yi-Shiou Chiou, Inga Wang, Chan-Yen Kuo   +4 more
doaj   +2 more sources

Four novel mutations of sterol 27-hydroxylase gene in Italian patients with cerebrotendinous xanthomatosis

Journal of Lipid Research, 1997
We report the characterization of eight mutations of sterol 27-hydroxylase gene (CYP27) in five Italian patients with cerebrotendinous xanthomatosis, who were found to be compound heterozygotes.
R Garuti, M A Croce, R Tiozzo, M T Dotti, A Federico, S Bertolini, S Calandra   +6 more
doaj   +3 more sources

Transcriptional Regulation of Human CYP27 Integrates Retinoid, Peroxisome Proliferator-Activated Receptor, and Liver X Receptor Signaling in Macrophages

Molecular and Cellular Biology, 2004
Cholesterol uptake and efflux are key metabolic processes associated with macrophage physiology and atherosclerosis. Peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) have been linked to the regulation of ...
Istvan Szatmari, László Nagy, Szilvia Benkő   +2 more
exaly   +1 more source