Results 41 to 50 of about 4,690 (123)

Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis

Journal of Lipid Research, 2007
Ontogenic changes in the rat bile acid (BA) pool, measured enzymatically and by GC-MS, and expression of enzymes (5α-reductase, 5β-reductase, and cytochrome P450 enzymes Cyp7a1, Cyp8b1, Cyp27 and Cyp3a11), transporters [bile salt export pump, sodium ...
Susana Cuesta de Juan, Maria J. Monte, Rocio I.R. Macias, Valérie Wauthier, Pedro Buc Calderon, Jose J.G. Marin   +5 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 176, Issue S1, Page S1-S20, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies, CGTP Collaborators, Thiruma V Arumugam, Andrew Bennett, Benita Sjögren, Christopher Sobey, Szu Shen Wong   +24 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

British Journal of Pharmacology, Volume 176, Issue S1, Page S297-S396, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators, Annie Beuve, Detlev Boison, Peter Brouckaert, John C Burnett, Kathryn Burns, Carmen Dessauer, Andreas Friebe, John Garthwaite, Jürg Gertsch, Nuala Helsby, Angelo A Izzo, Doris Koesling, Michaela Kuhn, Rennolds Ostrom, Andreas Papapetropoulos, Lincoln R Potter, Nigel J Pyne, Susan Pyne, Michael Russwurm, Harald HHW Schmidt, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts   +39 more
wiley   +1 more source

Novel homozygous and compound heterozygous mutations of sterol 27-hydroxylase gene (CYP27) cause cerebrotendinous xanthomatosis in three Japanese patients from two unrelated families

Journal of Lipid Research, 1997
The autosomal recessively inherited cholesterol metabolic disease, cerebrotendinous xanthomatosis (CTX), is caused by mutations in the sterol 27-hydroxylase gene. Three Japanese CTX patients from two unrelated families were studied genetically.
W Chen, S Kubota, K S Kim, J Cheng, M Kuriyama, G Eggertsen, I Björkhem, Y Seyama   +7 more
doaj   +1 more source

Selective Oxidation of Vitamin D3 Enhanced by Long‐Range Effects of a Substrate Channel Mutation in Cytochrome P450BM3 (CYP102A1)

Chemistry – A European Journal, Volume 30, Issue 51, September 11, 2024.
Long‐range effects from mutation of a substrate access tunnel residue selected by docking‐guided design of cytochrome P450BM3 (CYP102A1) to loosen the interaction between two secondary structure elements reshaped the substrate binding pocket and increased the activity for the oxidation vitamin D3 to 25‐hydroxy‐vitamin D3, an important human and animal ...
Wenyu Chen, Jamie N. C. Lynch, Claudia Bustamante, Yuan Zhang, Luet L. Wong   +4 more
wiley   +1 more source

N‐3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models

Canadian Journal of Gastroenterology and Hepatology, Volume 2018, Issue 1, 2018., 2018
Cholestasis is characterized by the accumulation of toxic bile acids (BAs) in liver cells. The present study aimed to evaluate the effects of n‐3 polyunsaturated fatty acids (n‐3 PUFAs), such as docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, on BA homeostasis and toxicity in human cell models. The effects of EPA and/or DHA on the expression of
Anna Cieślak, Jocelyn Trottier, Mélanie Verreault, Piotr Milkiewicz, Marie-Claude Vohl, Olivier Barbier, José L. Mauriz   +6 more
wiley   +1 more source

1,25-Dihydroxyvitamin D Decreases Tertiary Butyl-Hydrogen Peroxide-Induced Oxidative Stress and Increases AMPK/SIRT1 Activation in C2C12 Muscle Cells

Molecules, 2019
Enhanced oxidative stress has been associated with muscle mitochondrial changes and metabolic disorders. Thus, it might be a good strategy to decrease oxidative stress and improve mitochondrial changes in skeletal muscle.
Eugene Chang
doaj   +1 more source

Genome sequencing, comparative analysis, and gene expression responses of cytochrome P450 genes in Oryzias curvinotus provide insights into environmental adaptation

Ecology and Evolution, Volume 14, Issue 6, June 2024.
This chromosome‐level genomic resource provides crucial biological insights to elucidate the functional roles of expanded CYPs in environmental adaptation, sexual development, early life history, and conservation in the anthropogenically impacted mangrove habitats of O. curvinotus.
Ming Li, Aiping Deng, Chuanmeng He, Zebin Yao, Zixuan Zhuo, Xiu yue Wang, Zhongduo Wang   +6 more
wiley   +1 more source