Results 51 to 60 of about 4,690 (123)

Peroxisome Proliferator‐Activated Receptor‐γ Prevents Cholesterol Gallstone Formation in C57bl Mice by Regulating Bile Acid Synthesis and Enterohepatic Circulation

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
To investigate the role of the peroxisome proliferator‐activated receptor‐γ (PPARγ) in the progression of cholesterol gallstone disease (CGD), C57bl/6J mice were randomized to the following groups (n=7/group): L (lithogenic diet, LGD), LM (LGD+pioglitazone), CM (chow diet+pioglitazone), and NC (normal control, chow diet).
Gang Wang, Tao Han, ShiJia Wang, Min Chen, Yueming Sun, Zan Fu, Rajnish Chaturvedi   +6 more
wiley   +1 more source

Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages [PDF]

, 2003
Sterol 27-hydroxylase has been suggested to be involved in an alternative pathway for the elimination of cholesterol from macrophages and early atherosclerotic lesions.
Schmitz, Gerd, Babiker, Amir, Hansson, Magnus, Ellis, Ewa, Hunt, Mary C   +4 more
core   +1 more source

Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene [PDF]

, 1998
Sterol 27-hydroxylase is important for the degradation of the steroid side chain in conversion of cholesterol into bile acids and has been ascribed a regulatory role in cholesterol homeostasis.
Rosen, Haim, Björkhem, Ingemar, Eggertsen, G., Reshef, A., Bjorkhem, I., Lippoldt, Andrea, Eggertsen, Gösta, Maeda, N., Triger, Liat, Rosen, H., Leitersdorf, E., Lippoldt, A., Shpizen, Shoshi, Leitersdorf, Eran, Shpizen, S., Reshef, Ayeleth, Triger, L., Maeda, Nobuyo   +17 more
core   +1 more source

Two Cases Of Cerebrotendinous Xanthomatosis And A Short Review Of Pathophysiology

Annals of Indian Academy of Neurology, 2002
Cerebrotendinous Xanthomatosis(CTX) is an uncommon autosomal recessive disorder in which there is accumulation of cholestanol in tissues such as lens, tendons and nervous system.
Sinha S, Mahadevan A, Taly AB, Arunodaya G.R, Shankar SK   +4 more
doaj  

Expression of sterol 27-hydroxylase in GLIAL cells and its regulation by liver X receptor signaling

, 2009
Cholesterol is required in the brain for synaptogenesis and its turnover is critical for cerebral functions. Several proteins involved in cholesterol handling and metabolism are transcriptionally regulated by the nuclear liver X receptor (LXR) α and β ...
A. Torri, M. Boraso, F. Gilardi, S. Bartesaghi, B. Viviani, M. Crestani, A. Galmozzi, E. de Fabiani, D. Caruso, M. Marinovich   +9 more
core   +4 more sources

Magreceptorok szerepe a makrofágok fejlődésében és funkciójában [PDF]

, 2004
Nuclear receptors are ligand-activated transcription factors that regulate many aspects of metazoan life. In vivo, a biologically active, functional nuclear receptor requires obviously the protein of the transcription factor, an endogenous ligand that ...
Szántó, Attila
core  

Elevated expression of the genes encoding TNF-alpha and thromboxane synthase in leucocytes from patients with systemic sclerosis

, 2002
Objective. To determine the expression of molecular markers of prostanoid/fatty acid signalling in leucocytes of patients with systemic sclerosis (SSc). Methods.
Vosper, H., Ho, M., Palmer, C. N. A.; id_orcid, Young, V., Belch, J. J. F.; id_orcid   +4 more
core   +1 more source

Differential effects of 17 alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat

, 1999
Effects of 17 alpha-ethinylestradiol (EE) on the neutral and acidic biosynthetic pathways of bile salt (BS) synthesis were evaluated in rats with an intact enterohepatic circulation and in rats with long-term bile diversion to induce BS synthesis, For ...
Kuipers, F; id_orcid, Stellaard, F, Princen, HMG, Wolters, H, Post, SM, Boverhof, R, Koopen, NR, Havinga, R   +7 more
core  

Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer. [PDF]

Front Immunol
Liu Q, Liu X, Zhang H, Jiang Y, Shi Y, Mu Q, Jing Y, Sun D.   +7 more
europepmc   +1 more source

Dysbiosis in the Gut-Liver Axis Is Associated With Low Bone Mass During Murine Cholestasis. [PDF]

FASEB J
Hutchison B, Fornsaglio J, Case R, Cornuet P, Qin FY, Ma X, Nejak-Bowen K, Carson MD.   +7 more
europepmc   +1 more source