Results 21 to 30 of about 4,690 (123)

Sex difference in flux of 27‐hydroxycholesterol into the brain

British Journal of Pharmacology, Volume 178, Issue 16, Page 3194-3204, August 2021., 2021
Background and Purpose The cerebrospinal fluid (CSF)/plasma albumin ratio (QAlb) is believed to reflect the integrity of the blood–brain barrier (BBB). Recently, we reported that QAlb is lower in females. This may be important for uptake of neurotoxic 27‐hydroxycholesterol (27OH) by the brain in particular because plasma levels of 27OH are higher in ...
Cristina Parrado‐Fernandez, Valerio Leoni, Ahmed Saeed, Patricia Rodriguez‐Rodriguez, Anna Sandebring‐Matton, Carmen M. Córdoba‐Beldad, Paula Bueno, Chaitanya Chakravarthi Gali, Ute Panzenboeck, Angel Cedazo‐Minguez, Ingemar Björkhem   +10 more
wiley   +1 more source

Cerebrotendinous xanthomatosis: Clinical and neuroimaging findings

Archives of Medicine and Health Sciences, 2020
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of effective bile acid biosynthesis (adult lipid storage disorder with the underlying mutation in the CYP27 gene, which encodes sterol 27-hydroxylase, a key enzyme in the ...
S Sheetal, P Byju
doaj   +1 more source

The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation

Annals of Hepatology, 2021
Introduction and Objectives: The incidence of gallstone-related disease steadily increased in the last few years. Here, we aimed to investigate the effect of tauroursodeoxycholic acid11 TUDCA: tauroursodeoxycholic acid (TUDCA) on preventing cholesterol ...
Qifan Lu, Zhaoyan Jiang, Qihan Wang, Hai Hu, Gang Zhao   +4 more
doaj   +1 more source

Fine-mapping, mutation analyses, and structural mapping of cerebrotendinous xanthomatosis in U.S. pedigrees

Journal of Lipid Research, 2001
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of bile acid biosynthesis. Clinically, CTX patients present with tendon xanthomas, juvenile cataracts, and progressive neurological dysfunction and can be diagnosed by the ...
Mi-Hye Lee, Starr Hazard, John D. Carpten, Sonia Yi, Jonathan Cohen, Glenn T. Gerhardt, Gerald Salen, Shailendra B. Patel   +7 more
doaj   +1 more source

Trascriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator activated receptor, and liver X receptor signaling in macrophages [PDF]

, 2004
Cholesterol uptake and efflux are key metabolic processes associated with macrophage physiology and atherosclerosis. Peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) have been linked to the regulation of ...
L. Nagy, Bálint, Bálint László, Molnár, Sándor, A. Szanto, I. Furtos, I. Szatmari, R. Ruhl, Nagy, László, GARUTI, Rita, BL Balint, Szántó, Attila, Furtos, Ibolya, CALANDRA BUONAURA, Sebastiano, Larsson, Hann, S. Molnar, L. Csiba, Rühl, Ralph, S. Benko, Diczfalusy, Ulf, Benkő, Szilvia, Calandra, Sebastian, Szatmári, István, U. Diczfalusy, H. Larsson, Csiba, László   +24 more
core   +1 more source

A point mutation in the bile acid biosynthetic enzyme sterol 27-hydroxylase in a family with cerebrotendinous xanthomatosis.

Journal of Lipid Research, 1994
Cerebrotendinous xanthomatosis (CTX) is a rare familial disorder characterized by progressive neurological dysfunction, atherosclerosis, and xanthomas with sterol storage in the nervous system, vessels, and tendons.
N. Nakashima, Y. Sakai, H. Sakai, T. Yanase, M. Haji, F. Umeda, S. Koga, T. Hoshita, H. Nawata   +8 more
doaj   +1 more source

A novel mutation in the cytochrome P450(27) (CYP27) gene caused cerebrotendinous xanthomatosis in a Japanese family

Journal of Lipid Research, 1996
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage disease caused by mutations in the cytochrome P450(27) (CYP27) gene. This disease is characterized by the accumulation of a bile alcohol, cholestanol, in diverse tissues ...
E Okuyama, S Tomita, H Takeuchi, Y Ichikawa   +3 more
doaj   +1 more source

FXR-Induced Secretion of FGF15/19 Inhibits CYP27 Expression in Cholangiocytes Through p38 Kinase Pathway [PDF]

, 2014
Cholangiocytes, bile duct lining cells, actively adjust the amount of cholesterol and bile acids in bile through expression of enzymes and channels involved in transportation and metabolism of the cholesterol and bile acids.
Wang, Li, Webb, Paul, Francis, Heather L, Moore, David D, Francis, Heather L., Jung, Dongju, York, J Philippe, LeSage, Gene D, Yang, Chaofeng, Moore, David D., York, J. Philippe, McKeehan, Wallace L, Zhang, Aijun, Alpini, Gianfranco, LeSage, Gene D., Xia, Xuefeng, McKeehan, Wallace L.   +16 more
core   +1 more source

Long‐Term β‐galacto‐oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western‐Type Diet

Molecular Nutrition &Food Research, Volume 64, Issue 12, June 2020., 2020
Dietary fibers such as galacto‐oligosaccharides (GOS) stimulate the growth of beneficial bacteria that can modulate metabolic disease development. Western‐style diets largely contribute to the development of metabolic‐syndrome‐related diseases. The present study in mice demonstrates that GOS supplementation to a “Western” diet reduces body weight gain ...
Rima H. Mistry, Fan Liu, Klaudyna Borewicz, Mirjam A. M. Lohuis, Hauke Smidt, Henkjan J. Verkade, Uwe J. F. Tietge   +6 more
wiley   +1 more source

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

Journal of Lipid Research, 2001
The major oxysterols in human circulation are 7α-, 27-, and (24S)-hydroxycholesterol. Two unique experiments were performed to elucidate their origin and kinetics. A volunteer was exposed to 18O2-enriched air. A rapid incorporation of 18O in both 7α- and
Steve Meaney, Moustapha Hassan, Augustinas Sakinis, Dieter Lütjohann, Klaus von Bergmann, Åke Wennmalm, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source