Results 71 to 80 of about 16,625 (183)

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[S]

Journal of Lipid Research, 2014
Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen, Kaja Lund, Tore Vehus, Nina Solberg, Caroline Vesterdal, Dorna Misaghian, Petter Angell Olsen, Stefan Krauss, Steven Ray Wilson, Elsa Lundanes   +9 more
doaj   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

, 2002
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) into amyloidogenic components with the consequence of the acceleration ...
Jessen, F, Bagli, M., Lütjohann, D., Jessen, F., von Bergmann, K., Papassotiropoulos, A., Buschfort, R, Locatelli, S, Von Bergmann, K, Buschfort, R., Papassotiropoulos, A, Ptok, U, Locatelli, S., Heun, R., Heun, R, Lutjohann, D, Bjorkhem, A, von, Bergmann K, Bagli, M, Heun, Reinhard, Björkhem, I., Ptok, U., Björkhem, I,   +22 more
core   +1 more source

Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MSs⃞

Journal of Lipid Research, 2009
We describe a highly sensitive and specific method for the quantification of key regulatory oxysterols in biological samples. This method is based upon a stable isotope dilution technique by liquid chromatography-tandem mass spectrometry (LC-MS/MS ...
Akira Honda, Kouwa Yamashita, Takashi Hara, Tadashi Ikegami, Teruo Miyazaki, Mutsumi Shirai, Guorong Xu, Mitsuteru Numazawa, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

Frontiers in Molecular Neuroscience, 2020
The manipulation of cholesterol and its metabolites has been hypothesized to be therapeutically beneficial for mood disorders, neurodegenerative disorders, and epilepsies.
Michael Popiolek, Yukitoshi Izumi, Allen T. Hopper, Jing Dai, Silke Miller, Hong-Jin Shu, Charles F. Zorumski, Steven Mennerick   +7 more
doaj   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

, 2017
Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence, while the use of statins, cholesterol biosynthesis inhibitors widely used for treating hypercholesterolemia, is associated with improved disease-free survival ...
Suzanne E. Wardell, J. Will Thompson, Sanghoon Kwon, Ruchita V. Pillai, Sisi He, Amy E. Baek, Hannah B. McDowell, Donald P. McDonnell, Laura G. Dubois, Jongsook K. Kemper, Michael D. Gunn, Erik R. Nelson, Ching-Yi Chang, Yen-Rei A. Yu, Patrick M. Sullivan   +14 more
core   +1 more source

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

Journal of Lipid Research, 2000
We have previously presented evidence that most of the 24S-hydroxycholesterol present in the circulation originates from the brain and that most of the elimination of this oxysterol occurs in the liver.
Lionel Bretillon, Dieter Lütjohann, Lars Ståhle, Torulf Widhe, Lutz Bindl, Gösta Eggertsen, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

The Influence of Dietary Cholesterol on 26-Hydroxycholesterol and the Effect of 26-Hydroxycholesterol on the Intracellular Free Calcium Level

, 1987
Oxidized derivatives of cholesterol, such as 26-hydroxycholesterol are an enzymatic oxidation product of cholesterol, which have been studied in vivo and in vitro systems.
Kou, I-Ling
core  

Soybean phytoestrogens reduce 27-hydroxycholesterol concentration in the liver of middle-aged female rats

, 2017
Hypercholesterolemia is associated with athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute to prevention and treatment of modifiable risk factors.Purified soybean ...
Verica Milošević, Miler, Marko, Filipović, Branko, Milošević, Verica, Branko Filipović, Vladimir Ajdžanović, Branka Šošić-Jurjević, Marko Miler, Lutjohann, Dieter, Snežana Janković, Ivana Jarić, Šošić-Jurjević, Branka, Janković, Snežana, Ajdžanović, Vladimir, Dieter Lutjohann, Jarić, Ivana   +15 more
core   +1 more source