Results 81 to 90 of about 17,936 (215)

Relevance of 24S-hydroxycholesterol as a biomarker of optic neuropathies

, 2009
 Purpose: 24S-Hydroxycholesterol is formed by enzymatic oxidation of cholesterol via cholesterol-24S-hydroxylase (CYP46A1) activity in neurons, including retinal ganglion cells and neurons from the inner retina.
Brétillon, Lionel, Pasquis, Bruno, Martine, Lucy, Bjorkhem, Ingemar, Schnebelen, Coralie, Bron, Alain, Acar, Niyazi, Creuzot Garcher, Catherine, Fourgeux, Cynthia   +8 more
core   +1 more source

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[S]

Journal of Lipid Research, 2014
Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen, Kaja Lund, Tore Vehus, Nina Solberg, Caroline Vesterdal, Dorna Misaghian, Petter Angell Olsen, Stefan Krauss, Steven Ray Wilson, Elsa Lundanes   +9 more
doaj   +1 more source

Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

Frontiers in Molecular Neuroscience, 2020
The manipulation of cholesterol and its metabolites has been hypothesized to be therapeutically beneficial for mood disorders, neurodegenerative disorders, and epilepsies.
Michael Popiolek, Yukitoshi Izumi, Allen T. Hopper, Jing Dai, Silke Miller, Hong-Jin Shu, Charles F. Zorumski, Steven Mennerick   +7 more
doaj   +1 more source

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan   +4 more
wiley   +1 more source

26-Hydroxycholesterol: synthesis, metabolism, and biologic activities

Journal of Lipid Research, 1990
Cholest-5-ene-3 beta,26-diol (26-hydroxycholesterol) is synthesized by a mitochondrial P-450 enzyme that appears to be widely distributed in tissues. Together with other C-27 steroid intermediates it is transported to the liver and metabolized to bile ...
NB Javitt
doaj   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis

, 2007
Levels of the brain-specific cholesterol metabolite 24S-hydroxycholesterol are proposed as possible biomarkers for multiple sclerosis (MS). It is not yet clear for which aspect of the MS disease manifestations 24S-hydroxycholesterol is a reflection.
Dijkstra, C D, Sonke, M, Floris, S, De Vries, H E, Lütjohann, D, Teunissen, C E   +5 more
core   +1 more source

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

Journal of Lipid Research, 2000
We have previously presented evidence that most of the 24S-hydroxycholesterol present in the circulation originates from the brain and that most of the elimination of this oxysterol occurs in the liver.
Lionel Bretillon, Dieter Lütjohann, Lars Ståhle, Torulf Widhe, Lutz Bindl, Gösta Eggertsen, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

, 2002
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) into amyloidogenic components with the consequence of the acceleration ...
Jessen, F, Bagli, M., Lütjohann, D., Jessen, F., von Bergmann, K., Papassotiropoulos, A., Buschfort, R, Locatelli, S, Von Bergmann, K, Buschfort, R., Papassotiropoulos, A, Ptok, U, Locatelli, S., Heun, R., Heun, R, Lutjohann, D, Bjorkhem, A, von, Bergmann K, Bagli, M, Heun, Reinhard, Björkhem, I., Ptok, U., Björkhem, I,   +22 more
core   +1 more source

Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway

Journal of Lipid Research, 1998
Reduced cholesterol synthesis has been reported in patients with primary biliary cirrhosis but no data are available on changes in cholesterol catabolism induced by the disease.
M. Del Puppo, M. Galli Kienle, M.L. Petroni, A. Crosignani, M. Podda   +4 more
doaj   +1 more source