Results 91 to 100 of about 16,625 (183)

Relevance of 24S-hydroxycholesterol as a biomarker of optic neuropathies

, 2009
Purpose: 24S-Hydroxycholesterol is formed by enzymatic oxidation of cholesterol via cholesterol-24S-hydroxylase (CYP46A1) activity in neurons, including retinal ganglion cells and neurons from the inner retina.
Pasquis, Bruno, Martine, Lucy, Bjorkhem, Ingemar, Bretillon, Lionel, Schnebelen, Coralie, Bron, Alain, Acar, Niyazi, Creuzot Garcher, Catherine, Fourgeux, Cynthia   +8 more
core  

Oxygenation of desmosterol and cholesterol in cell cultures.

Journal of Lipid Research, 1990
In order to determine whether hydration of the delta 24 bond of desmosterol contributes to the formation of the regulatory oxysterol, 25-hydroxycholesterol, [3H]desmosterol was incubated with two cultured cell lines and the labeled products were analyzed.
SE Saucier, AA Kandutsch, AK Gayen, JA Nelson, TA Spencer   +4 more
doaj   +1 more source

Measurement of cholesterol 7 alpha-hydroxylase activity with selected ion monitoring.

Journal of Lipid Research, 1981
Formation of 7 alpha-hydroxycholesterol by rat liver microsomes was quantitated using a gas chromatograph-mass spectrometer operated in selected ion monitoring mode.
A Sanghvi, E Grassi, C Bartman, R Lester, M Galli Kienle, G Galli   +5 more
doaj   +1 more source

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7 alpha-hydroxylase (CYP7A)

, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Toll, Anders,, Bjorkhem, Ingemar, Wikvall, Kjell,, Norlin, Maria,   +3 more
core  

Collisional Spectroscopy Approaches In the Characterization of 7-alpha-hydroxycholesterol and 7-beta-hydroxycholesterol

, 1991
High- and low-energy collision experiments, by means of double-focusing and ion-trap mass spectrometers, respectively, performed on the M+. and [M-H2O]+.
R. SERAGLIA, A. SEVANIAN, F. GUIDUGLI, FAVRETTO, DONATA, P. TRALDI, F. URSINI   +5 more
core   +1 more source

4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters

, 2020
Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol.
Savolainen, Markku J., Salonurmi, Tuire, Ronkainen, Justiina, Hautajärvi, Heidi, Nabil, Heba, Tolonen, Ari, Hakkola, Jukka, Hukkanen, Janne, Hyötyläinen, Tuulia, Orešič, Matej, Känsäkoski, Päivi, Rysä, Jaana   +11 more
core   +1 more source

Clemmensen reduction of diosgenin and kryptogenin: synthesis of [16,16,22,22,23,23-H-2(6)]-(25R)-26-hydroxycholesterol.

, 2004
A new experimental protocol has been established for the Clemmensen reduction of diosgenin and kryptogenin with the aim to prepare deuterated isotopomers of (25R)-26-hydroxycholesterol.
E. Santaniello, G. Terraneo, P. Ciuffreda, L. Alessandrini   +3 more
core   +1 more source

Protective effects of 27-and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

, 2012
Alterations in cholesterol metabolism have been linked to several neurodegenerative disorders, including Alzheimer's disease, multiple sclerosis and Parkinson's disease.
Norlin, Maria,, Emanuelsson, Ida,
core   +1 more source

DataSheet_1_4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.pdf

, 2020
Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol.
Jaana Rysä (314845), Tuulia Hyötyläinen (139327), Heidi Hautajärvi (8627643), Justiina Ronkainen (8627640), Janne Hukkanen (648692), Jukka Hakkola (298462), Markku J. Savolainen (8397378), Ari Tolonen (1456093), Päivi Känsäkoski (8627646), Tuire Salonurmi (296831), Heba Nabil (8627637), Matej Orešič (43155)   +11 more
core   +1 more source

Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping

Clinical and Translational Science
Plasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. Plasma 4β‐OHC is produced by hydroxylation by CYP3A4 and CYP3A5 and by cholesterol autoxidation.
Ayako Oda, Yosuke Suzuki, Haruki Sato, Teruhide Koyama, Masahiro Nakatochi, Yukihide Momozawa, Ryota Tanaka, Hiroyuki Ono, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Kenji Wakai, Keitaro Matsuo, Hiroki Itoh, Keiko Ohno   +14 more
doaj   +1 more source