Results 91 to 100 of about 17,936 (215)

The Influence of Dietary Cholesterol on 26-Hydroxycholesterol and the Effect of 26-Hydroxycholesterol on the Intracellular Free Calcium Level

, 1987
Oxidized derivatives of cholesterol, such as 26-hydroxycholesterol are an enzymatic oxidation product of cholesterol, which have been studied in vivo and in vitro systems.
Kou, I-Ling
core  

Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells.

Journal of Lipid Research, 1995
Oxysterols serve as both substrates and signal molecules in the cholesterol-utilizing pathways of mammalian cells. Their distribution and movement within these cells, however, have not been well characterized; therefore we have undertaken such an ...
Y Lange, J Ye, F Strebel
doaj   +1 more source

Are side-chain oxidized oxysterols regulators also in vivo?

Journal of Lipid Research, 2009
Oxsterols are oxygenated metabolites of cholesterol that are short-lived intermediates or end products in cholesterol excretion pathways. They are present in very low concentrations in mammalian systems, always accompanied by a high excess of cholesterol.
Ingemar Bjo¨rkhem
doaj   +1 more source

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

, 2017
Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence, while the use of statins, cholesterol biosynthesis inhibitors widely used for treating hypercholesterolemia, is associated with improved disease-free survival ...
Suzanne E. Wardell, J. Will Thompson, Sanghoon Kwon, Ruchita V. Pillai, Sisi He, Amy E. Baek, Hannah B. McDowell, Donald P. McDonnell, Laura G. Dubois, Jongsook K. Kemper, Michael D. Gunn, Erik R. Nelson, Ching-Yi Chang, Yen-Rei A. Yu, Patrick M. Sullivan   +14 more
core   +1 more source

Cerebrotendinous xanthomatosis: reduced serum 26-hydroxycholesterol.

Journal of Lipid Research, 1982
Serum 26-hydroxycholesterol was quantitated by isotope dilution-mass spectrometry in normal individuals and in patients with cerebrotendinous xanthomatosis. In the normal individuals, the concentration of 26-hydroxycholesterol in serum ranged from 4.3 to
N B Javitt, E Kok, B Cohen, S Burstein
doaj   +1 more source

The convenient synthesis of 25-hydroxycholesterol.

Chemical and Pharmaceutical Bulletin, 1979
The convenient synthesis of 25-hydroxycholesterol (6) is described. 5β-Cholestan-3α, 25-diol (2) derived from lithocholic acid was converted to 6 via four steps : oxidationbromination, dehydrobromination, deconjugation, and reduction. The overall yield of 25-hydroxycholesterol (6) starting from 2 was ca. 50%.
OCHI, KIYOSHIGE, MATSUNAGA, ISAO, SHINDO, MINORU, KANEKO, CHIKARA   +3 more
openaire   +2 more sources

Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage

, 2020
Oxysterols have long been believed to be ligands of nuclear receptors such as liver × receptor (LXR), and they play an important role in lipid homeostasis and in the immune system, where they are involved in both transcriptional and ...
Shunlin Ren, Yaping Wang, Xiaobo Li
core   +1 more source

Measurement of cholesterol 7 alpha-hydroxylase activity with selected ion monitoring.

Journal of Lipid Research, 1981
Formation of 7 alpha-hydroxycholesterol by rat liver microsomes was quantitated using a gas chromatograph-mass spectrometer operated in selected ion monitoring mode.
A Sanghvi, E Grassi, C Bartman, R Lester, M Galli Kienle, G Galli   +5 more
doaj   +1 more source

Soybean phytoestrogens reduce 27-hydroxycholesterol concentration in the liver of middle-aged female rats

, 2017
Hypercholesterolemia is associated with athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute to prevention and treatment of modifiable risk factors.Purified soybean ...
Verica Milošević, Miler, Marko, Filipović, Branko, Milošević, Verica, Branko Filipović, Vladimir Ajdžanović, Branka Šošić-Jurjević, Marko Miler, Lutjohann, Dieter, Snežana Janković, Ivana Jarić, Šošić-Jurjević, Branka, Janković, Snežana, Ajdžanović, Vladimir, Dieter Lutjohann, Jarić, Ivana   +15 more
core   +1 more source

CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4 beta-hydroxycholesterol levels

, 2008
Objective and methods A member of the major human cytochrome P450 superfamily of hemoproteins, CYP3A4/5, converts cholesterol into 4 beta-hydroxycholesterol.
Bottiger, Y, Flamholc, L., Bertilsson, L., Ormaasen, V, Diczfalusy, U., Ormaasen, V., Bottiger, Y., Gisslén, Magnus,, Josephson, F, Bertilsson, L, Gisslen, M, Flamholc, Leo, Diczfalusy, U, Sonnerborg, A, Josephson, F., Sönnerborg, A.   +15 more
core   +1 more source