Results 21 to 30 of about 17,936 (215)

Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells.

Journal of Lipid Research, 1983
The regulation of rabbit intestinal acyl CoA:cholesterol acyltransferase (ACAT) by 25-hydroxycholesterol was studied. 25-Hydroxycholesterol significantly increased jejunal microsomal ACAT activity.
F J Field, S N Mathur
doaj   +1 more source

Bile acid synthesis in man. II. Determination of 7 α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and 26-hydroxycholesterol in human meconium

Journal of Lipid Research, 1977
7 α-Hydroxycholesterol, (22R)-22-hydroxycholesterol and 26-hydroxycholesterol have been quantitated in human meconium. The method used tetrahydrofuran for extraction and solvolysis of the sulfate esters, liquid partition chromatography for the separation
U Lavy, S Burstein, M Gut, N B Javitt
doaj   +1 more source

Serum 4β-hydroxycholesterol increases during fluconazole treatment

, 2020
Purpose: The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity.
Kerksiek, Anja, Lötsch, Jörn, Stellaard, Frans, Lütjohann, Dieter, Oertel, Bruno Georg, Oertel, Bruno G   +5 more
core   +2 more sources

Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro

Viruses, 2023
Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble, Vishwanatha R. A. P. Reddy, Ben Jackson, Faisal R. Anjum, Chidiebere C. Ubachukwu, Ajit Patil, Shahriar Behboudi   +6 more
openaire   +4 more sources

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol

, 2023
Oxysterols are oxidized derivatives of cholesterol that are formed by enzymatic processes or through the action of reactive oxygen species. Several of these bioactive lipids have been shown to be affected and/or play a role in inflammatory processes.
Roumain, Martin, Guillemot-Legris, Owein, Al Houayek, Mireille, Muccioli, Giulio, Mireille Alhouayek, Ameraoui, Hafsa, Martin Roumain, Hafsa Ameraoui, Giulio G. Muccioli, Owein Guillemot-Legris   +9 more
core   +1 more source

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Journal of Lipid Research, 2002
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney, Karl Bodin, Ulf Diczfalusy, Ingemar Björkhem   +3 more
doaj   +1 more source

Membrane properties of hydroxycholesterols related to the brain cholesterol metabolism

Beilstein Journal of Organic Chemistry, 2017
Compared to cholesterol, hydroxycholesterols contain an additional hydroxy group in the alkyl chain and are able to efficiently cross the brain–blood barrier. Therefore, they are responsible for the sterol transfer between brain and circulation.
Malte Hilsch, Ivan Haralampiev, Peter Müller, Daniel Huster, Holger A. Scheidt   +4 more
doaj   +1 more source

Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol

Journal of Lipid Research, 1999
25-Hydroxycholesterol negatively regulates cholesterol synthesis and activates cholesterol esterification in a variety of cultured cells. Concurrent with these effects, 25-hydroxycholesterol also stimulates the synthesis of sphingomyelin in Chinese ...
Thomas A. Lagace, David M. Byers, Harold W. Cook, Neale D. Ridgway   +3 more
doaj   +1 more source