Results 41 to 50 of about 927 (145)

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan, Ameer Y. Taha, Walter Swardfager   +2 more
wiley   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

The convenient synthesis of 25-hydroxycholesterol.

Chemical and Pharmaceutical Bulletin, 1979
The convenient synthesis of 25-hydroxycholesterol (6) is described. 5β-Cholestan-3α, 25-diol (2) derived from lithocholic acid was converted to 6 via four steps : oxidationbromination, dehydrobromination, deconjugation, and reduction. The overall yield of 25-hydroxycholesterol (6) starting from 2 was ca. 50%.
OCHI, KIYOSHIGE, MATSUNAGA, ISAO, SHINDO, MINORU, KANEKO, CHIKARA   +3 more
openaire   +2 more sources

The Configuration of 22-Hydroxycholesterol

Chemical and Pharmaceutical Bulletin, 1968
MORI, HIROMU, SHIBATA, KENYU, TSUNEDA, KIYOSHI, SAWAI, MASANOBU, TSUDA, KYOSUKE   +4 more
openaire   +3 more sources

The role of 27-hydroxycholesterol in meta-inflammation

The Korean Journal of Physiology & Pharmacology
27-Hydroxycholesterol (27OHChol), a prominent cholesterol metabolite present in the bloodstream and peripheral tissues, is a kind of immune oxysterol that elicits immune response. Recent research indicates the involvement of 27OHChol in metabolic inflammation (meta-inflammation) characterized by chronic responses associated with metabolic ...
Son, Yonghae, Choi, Eunbeen, Hwang, Yujin, Kim, Koanhoi   +3 more
openaire   +2 more sources

Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping

Clinical and Translational Science
AbstractPlasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. Plasma 4β‐OHC is produced by hydroxylation by CYP3A4 and CYP3A5 and by cholesterol autoxidation. Plasma 4α‐OHC is produced by cholesterol autoxidation and not affected by CYP3A activity.
Ayako Oda, Yosuke Suzuki, Haruki Sato, Teruhide Koyama, Masahiro Nakatochi, Yukihide Momozawa, Ryota Tanaka, Hiroyuki Ono, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Kenji Wakai, Keitaro Matsuo, Hiroki Itoh, Keiko Ohno   +14 more
openaire   +3 more sources

Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells. [PDF]

J Biol Chem, 2023
Lin YC, Cheung G, Zhang Z, Papadopoulos V.   +3 more
europepmc   +1 more source