Results 41 to 50 of about 6,185 (138)

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, Volume 101, Issue 5, Page 2103-2118, October 2026.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Cholesterol 25‐Hydroxylase Deficiency Provides an Optimal and Durable Protective T Helper 1 Immunity via Interleukin‐12–Interleukin‐2 Axis in BCG‐Vaccinated Mice

MedComm, Volume 7, Issue 10, October 2026.
CH25H deficiency permits optimal dendritic cell activation following BCG exposure, characterized by increased IL‐12p70 production. In vivo, CH25H deficiency promotes enhanced BCG‐mediated protection and sustained IL‐2 producing T cell response. ABSTRACT Bacillus Calmette‐Guérin (BCG) remains the only licensed vaccine for tuberculosis (TB), yet its ...
Hagyu Kim, Eunsol Choi, Kee Woong Kwon, Hong‐Hee Choi, Kyungmin Kim, WeonSeok Jung, Sung Jae Shin   +6 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Effect of 24S-Hydroxycholesterol on Cholesterol Homeostasis in Neurons: Quantitative Changes to the Cortical Neuron Proteome

, 2016
In humans, the brain represents only about 2% of the body’s mass but contains about one-quarter of the body’s free cholesterol. Cholesterol is synthesized de novo in brain and removed by metabolism to oxysterols.
Sabina Muneton (2445274), Jasmina N. Jovanovic (2445277), William J. Griffiths (2382700), Yuqin Wang (2382697), Jan Sjövall (2445271)   +4 more
core   +3 more sources

25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis

OncoTarget, 2017
This study aimed to evaluate the levels of three major hydroxycholesterols (24-, 25-, and 27-hydroxycholesterols) in the serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS), as well as to show their role in the ...
Sung-Min Kim, Min-Young Noh, Hee-Soo Kim, S. Cheon, Kang-Mi Lee, Jaeick Lee, E. Cha, K. Park, Kwang-Woo Lee, Jung-Joon Sung, Seung-Hyun Kim   +10 more
semanticscholar   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Associations between serum estradiol and estrone and Alzheimer's disease biomarkers: An analysis in female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study (EPAD LCS)

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Postmenopausal estrogen decline may contribute to Alzheimer's disease (AD), but evidence linking circulating estrogens to cerebrospinal fluid (CSF) AD biomarkers remains limited. METHODS We analyzed 854 female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study with baseline serum estradiol ...
Juehyun Shin, Graciela Muniz‐Terrera, Craig W. Ritchie, Jean Manson, Susan Plachecki, Clemens Kirschbaum, Sarah Gregory   +6 more
wiley   +1 more source

Serum VIP and IL‐1β Levels Are Associated With Anxiety and Depression in Patients With Parkinson's Disease: A Cross‐Sectional Study

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Background Anxiety and depressive symptoms frequently accompany Parkinson's disease (PD), yet the biological processes underlying these affective complications and their potential peripheral indicators remain incompletely understood. This study evaluated whether circulating concentrations of vasoactive intestinal peptide (VIP), interleukin‐1β (
Liangyu Li, Xiaoyang Jia, Ying Shi, Zexin Yuan, Caoyuan Niu, Yujing Huang, Xiaoli Zhang, Honglei Li, Tiantian Han, Yanji Cui, Pengge Fei, Guihua Wang, Ailing Du   +12 more
wiley   +1 more source

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan   +4 more
wiley   +1 more source