Bile acid metabolism and signaling in human and animal health: A One Health perspective
iMetaOmics, Volume 3, Issue 3, September 2026.Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li +7 more
wiley +1 more source
Emerging role of 7-Ketocholesterol and hydroxylated 7-Ketocholesterol in the Pathophysiology of Disease [PDF]
Cholesterol oxidation at the C7 position is a hallmark of non-enzymatic lipid peroxidation. Reactive oxygen species initiate hydrogen abstraction at the allylic C7 position of cholesterol, leading to the formation of 7-hydroperoxides, which subsequently ...
Dias, Irundika
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Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum
BMC Neuroscience, 2014 Cholesterol metabolism is important for the maintenance of myelin and neuronal membranes in the central nervous system. Blood concentrations of the brain specific cholesterol metabolite 24S-hydroxysterol to the peripheral metabolite 27-hydroxycholesterol
V. R. Bandaru, N. Haughey
semanticscholar +1 more source
Targeted Lipidomic Analysis of Oxysterols in the Embryonic Central Nervous System
Molecular Biosystems, 2009 Summary In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using high-performance liquid chromatography (HPLC) – mass spectrometry (MS) and tandem mass spectrometry ...
Yu-Qin Wang +10 more
semanticscholar +1 more source
Syntheses of possible steroid intermediates in bile acid biosynthesis [PDF]
, 1968 The structural relationship of cholesterol and bile acids was established on a chemical basis as early as the beginning of the 20th Century by Windaus. (For a review see "Steroids" by Fieser and Fieser.) but the first direct evidence that cholesterol
Ali, Saiyad Asad Maqsood
core +3 more sources
, 2009 Using a highly stereoselective Evans aldol reaction for the introduction of the stereogenic center at C-25, we describe an efficient synthesis of the orthogonally diprotected (25S)- 26-hydroxycholesterol 11.
Entchev, E. +9 more
core +1 more source
Relevance of Oxysterol 7-Alpha-Hydroxylase (CYP7B1) for Lipid Metabolism and Fatty Liver Disease
, 2022 Cold exposure and the simultaneous brown adipose tissue (BAT) activation are important determinants of metabolic processes such as carbohydrate and lipid metabolism. Recently, a new interplay between BAT and the liver was identified under which increased
Evangelakos, Ioannis
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Avaliação in vitro da atividade antioxidante dos carotenóides totais extraídos do músculo de camarões cultivados Litopenaeus vannamei [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2010Os carotenóides têm sido bastante investigados como agentes quimiopreventivos, funcionando como ...
Silva, Fabiana Ourique da
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Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells. [PDF]
J Biol Chem, 2023 Lin YC +3 more
europepmc +1 more source
Assay of cholesterol 7α-hydroxylase activity in rat hepatocytes in primary monolayer culture
, 1988 A sensitive and precise method is described to assay cholesterol 7α-hydroxylase activity in homogenates of rat hepatocytes cultured in monolayers for up to 76 h. The assay is based on measurement of the amount of radioactive cholesterol converted into 7α-
Meijer, P. +3 more
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