Results 11 to 20 of about 927 (145)
Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol [PDF]
Scientific Reports, 2014 AbstractRecent studies reported a broad but selective antiviral activity of 25-hydroxycholesterol (25HC) against enveloped viruses, being apparently inactive against non-enveloped viruses. Here we show that 25HC is endowed with a marked antiviral activity against three pathogenic non-enveloped viruses, i.e.
Civra, Andrea +6 more
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Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum [PDF]
BMC Neuroscience, 2014 Cholesterol metabolism is important for the maintenance of myelin and neuronal membranes in the central nervous system. Blood concentrations of the brain specific cholesterol metabolite 24S-hydroxysterol to the peripheral metabolite 27-hydroxycholesterol may be useful surrogate markers for neurodegenerative diseases including Alzheimer's disease ...
Bandaru, Veera Venkata Ratnam +1 more
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25-Hydroxycholesterol and 27-hydroxycholesterol induce neuroinflammation by activating microglia
, 2023 Abstract Interleukin-1β (IL-1β) levels and side-chain oxygenated cholesterol molecules (oxysterols) are elevated in the brains of patients with Alzheimer’s disease (AD), and high cholesterol levels increase the risk of AD. However, roles of high cholesterol and side-chain oxysterols in IL-1β expression remain to be determined.
Yonghae Son +4 more
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Journal of Lipid Research, 1996 Oxidation of low density lipoprotein (LDL) in the artery wall leads to the formation of cholesterol oxidation products that may result in cytotoxicity.
R P Patel +4 more
doaj +1 more source
Metabolism of 4β-Hydroxycholesterol in Humans [PDF]
Journal of Biological Chemistry, 2002 One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4. Deuterium-labeled 4 beta-hydroxycholesterol was injected into two healthy volunteers, and the apparent half-life was found to be 64 and 60 h, respectively.
Karl, Bodin +8 more
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25-Hydroxycholesterol in health and diseases [PDF]
Journal of Lipid ResearchCholesterol is an essential structural component of all membranes of mammalian cells where it plays a fundamental role not only in cellular architecture, but also, for example, in signaling pathway transduction, endocytosis process, receptor functioning and recycling, or cytoskeleton remodeling.
Cindy Nguyen +4 more
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Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol
Redox Biology, 2017 Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action. A marked antiviral activity not only of 25HC but also of 27HC against HSV-1 was observed either if the oxysterols were added before or ...
Cagno, V +9 more
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Effects of 26-Aminocholesterol, 27-Hydroxycholesterol, and 25-Hydroxycholesterol on Proliferation and Cholesterol Homeostasis in Arterial Myocytes [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 1995 AbstractThe major relation existing between cell growth and cholesterol homeostasis prompted us to investigate the effect of 26-aminocholesterol (26-NH2), 27-hydroxycholesterol (27-OH), and 25-hydroxycholesterol (25-OH) on these cellular events. To test this relation, we incubated human and rat arterial myocytes with the sterols for 72 hours.
A. Corsini +5 more
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Journal of lipid research, 1977 7 alpha-Hydroxycholesterol, (22R)-22-hydroxycholesterol and 26-hydroxycholesterol have been quantitated in human meconium. The method used tetrahydrofuran for extraction and solvolysis of the sulfate esters, liquid partition chromatography for the separation of the hydroxysterols, gas-liquid chromatography for quantitation, gas-liquid chromatography ...
U, Lavy +3 more
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The oncogenic roles of 27‑hydroxycholesterol in glioblastoma
Oncology Letters, 2019 Glioblastoma is the most frequent primary malignant brain tumor in adults. Oxysterols are oxidation products of cholesterol generated by enzymatic reactions. 27-hydroxycholesterol (27-HC), an oxysterol, is an abundant metabolite of cholesterol. 27-HC significantly accelerates mammary cancer growth, proliferation and progression in experimental models ...
Liu, Lu +4 more
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