Results 11 to 20 of about 6,185 (138)

Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.

Molecular Endocrinology, 2010
National Institutes of Health [DK081757]; American Heart Association; Science Planning Program of Fujian Province [2009J1010]; 111 Project [B06016]The retinoic acid-related orphan receptor gamma (ROR gamma) has important roles in development and ...
Dariusz Martynowski, Lihua Jin, Wen Xie
exaly   +3 more sources

Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro

Viruses, 2023
Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble, Vishwanatha R. A. P. Reddy, Ben Jackson, Faisal R. Anjum, Chidiebere C. Ubachukwu, Ajit Patil, Shahriar Behboudi   +6 more
doaj   +2 more sources

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer [PDF]

bioRxiv, 2020
Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy is typically restricted to cytotoxic chemotherapy, which fails more often in patients with elevated circulating ...
S. Hutchinson, A. Websdale, G. Cioccoloni, H. Ro̷berg-Larsen, P. Lianto, Baek Kim, A. Rose, C. Soteriou, Arindam Pramanik, L. Wastall, B. Williams, Madeline A. Henn, Joy J Chen, Liqian Ma, J. Moore, Erik R. Nelson, T. Hughes, J. Thorne   +17 more
semanticscholar   +2 more sources

Hydroxycholesterol Levels in the Serum and Cerebrospinal Fluid of Patients with Neuromyelitis Optica Revealed by LC-Ag+CIS/MS/MS and LC-ESI/MS/MS with Picolinic Derivatization: Increased Levels and Association with Disability during Acute Attack. [PDF]

PLoS ONE, 2016
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS). Hydroxycholesterols (OHCs), metabolites of CNS cholesterol, are involved in diverse cellular responses to inflammation and demyelination, and may ...
Eunju Cha, Kang Mi Lee, Ki Duk Park, Kyung Seok Park, Kwang-Woo Lee, Sung-Min Kim, Jaeick Lee   +6 more
doaj   +2 more sources

Cytochrome P-450scc-substrate interactions. Studies of binding and catalytic activity using hydroxycholesterols.

Journal of Biological Chemistry, 1982
H Kamin
exaly   +2 more sources

24-hydroxycholesterol moderates the effects of amyloid-β on expression of HMG-CoA reductase and ABCA1 proteins in mouse astrocytes

Advanced Biomedical Research, 2023
Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri, Ghorban Mohammadzadeh, Mojtaba Rashidi, Shirin Azizdoost, Maryam Cheraghzadeh, Alireza Kheirollah   +5 more
doaj   +1 more source

The stoichiometry of the conversion of cholesterol and hydroxycholesterols to pregnenolone (3beta-hydroxypregn-5-en-20-one) catalysed by adrenal cytochrome P-450.

Proceedings of the National Academy of Sciences of the United States of America, 1974
Mikio Shikita, Peter F. Hall
semanticscholar   +2 more sources

Pregnenolone synthesis from cholesterol and hydroxycholesterols by mitochondria from ovaries following the stimulation of immature rats with pregnant mare's serum gonadotropin and human choriogonadotropin.

European Journal of Biochemistry, 1989
R. Tuckey, Helen C. Atkinson
semanticscholar   +2 more sources

Metabolism of steroids: The 7-hydroxycholesterols as metabolites

Biochemical Journal, 1942
G A D Haslewood, G A Haslewood
exaly   +2 more sources

Lipidomic Expression Analysis in Carotid Atherosclerotic Disease: A Systematic Review. [PDF]

Ann Vasc Surg
Background: Lipids are key molecules for atherosclerosis, with tight regulation mechanisms, making them potential biomarkers for disease-specific diagnostics and therapeutics.
Polania-Sandoval C, Byeon SK, Hartwell J, Prudencio M, Petrucelli L, Brigham T, Meschia JF, Pandey A, Erben Y.   +8 more
europepmc   +2 more sources