The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus [PDF]
Viruses, 2019 Cholesterol, an essential component of mammalian cells, is also an important factor in the replicative-cycles of several human and animal viruses.
Ghada T. Shawli +3 more
doaj +6 more sources
Journal of Lipid Research, 1989 Three mammalian cell lines were examined for their ability to metabolize the regulatory oxysterol, 25-hydroxycholesterol, and derepress 3-hydroxy-3-methylglutaryl CoA reductase.
F R Taylor, A A Kandutsch
doaj +2 more sources
25-Hydroxycholesterol Increases the Availability of Cholesterol in Phospholipid Membranes [PDF]
Biophysical Journal, 2011 Side-chain oxysterols are enzymatically generated oxidation products of cholesterol that serve a central role in mediating cholesterol homeostasis. Recent work has shown that side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), alter membrane ...
Daniel S. Ory +7 more
core +3 more sources
Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol
Redox Biology, 2017 Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action.
Valeria Cagno +9 more
doaj +2 more sources
Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol.
Journal of Lipid Research, 1995 The effect of oxysterols on efflux of cholesterol from mouse L-cell fibroblasts, rat Fu5AH hepatoma cells, J774 macrophages, and human EA.hy 926 endothelial cells was studied.
E P Kilsdonk +3 more
doaj +3 more sources
SGLT2 Inhibitors May Restore Endothelial Barrier Interrupted by 25-Hydroxycholesterol. [PDF]
Molecules, 2023 SGLT2 (Sodium-glucose Cotransporter-2) inhibitors are newer glucose-lowering drugs with many cardiovascular benefits that are not fully understood yet. Endothelial integrity plays a key role in cardiovascular homeostasis.
Pawlos A +5 more
europepmc +2 more sources
25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes [PDF]
Redox Biology, 2018 A novel innate immune strategy, involving specific cholesterol oxidation products as effectors, has begun to reveal connections between cholesterol metabolism and immune response against viral infections.
Andrea Civra +6 more
doaj +2 more sources
25-Hydroxycholesterol as a Signaling Molecule of the Nervous System. [PDF]
Biochemistry (Mosc), 2022 Cholesterol is an essential component of plasma membrane and precursor of biological active compounds, including hydroxycholesterols (HCs). HCs regulate cellular homeostasis of cholesterol; they can pass across the membrane and vascular barriers and act distantly as para- and endocrine agents. A small amount of 25-hydroxycholesterol (25-HC) is produced
Odnoshivkina UG +2 more
europepmc +3 more sources
25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway
The International Journal of Biochemistry & Cell Biology, 2017 Mevalonate pathway deregulation has been observed in several diseases, including Mevalonate kinase deficiency (MKD). MKD is a hereditary auto-inflammatory disorder, due to mutations at mevalonate kinase gene (MVK), encoding mevalonate kinase (MK ...
Sergio Crovella +9 more
core +4 more sources
25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell Line. [PDF]
Molecules, 2021 25-hydroxycholesterol (25-HC) is an oxysterol synthesized from cholesterol by cholesterol-25-hydroxylase during cholesterol metabolism. The aim of this study was to verify whether 25-HC induces oxiapoptophagy in fibroblasts.
You JS +11 more
europepmc +2 more sources