Results 21 to 30 of about 4,298,356 (197)

Transformation of 25-Hydroxycholesterol by Rhizoctonia muneratii [PDF]

Applied and Environmental Microbiology, 1982
Rhizoctonia muneratii ATCC 13247 was capable of catalyzing the conversion of 25-hydroxycholesterol to the 3-oxo-4-ene. Hydroxylation at the 6α and 6β positions with the concomitant 3-oxo-4-ene transformation was also observed.
M E, Wozny, T R, Smith, R L, Angus, E T, Kaiser   +3 more
openaire   +2 more sources

Are side-chain oxidized oxysterols regulators also in vivo?

Journal of Lipid Research, 2009
Oxsterols are oxygenated metabolites of cholesterol that are short-lived intermediates or end products in cholesterol excretion pathways. They are present in very low concentrations in mammalian systems, always accompanied by a high excess of cholesterol.
Ingemar Bjo¨rkhem
doaj   +1 more source

Oxysterols and Retinal Microvascular Dysfunction as Early Risk Markers for Cardiovascular Disease in Normal, Ageing Individuals

Antioxidants, 2021
The aim of the present paper is to assess the relationship between oxysterol levels and retinal microvascular function in individuals of various age groups, free of clinically evident diseases.
Hala Shokr, Irundika HK Dias, Doina Gherghel   +2 more
doaj   +1 more source

Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol

Journal of Lipid Research, 1999
25-Hydroxycholesterol negatively regulates cholesterol synthesis and activates cholesterol esterification in a variety of cultured cells. Concurrent with these effects, 25-hydroxycholesterol also stimulates the synthesis of sphingomyelin in Chinese ...
Thomas A. Lagace, David M. Byers, Harold W. Cook, Neale D. Ridgway   +3 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The lipid 25-hydroxycholesterol (25HC) is produced by immune cells in response to infection. We demonstrate that in addition to interfering with viral entry and replication, 25HC also amplifies the activation of immune cells and increases the production of immune mediators.
Elizabeth S, Gold, Alan H, Diercks, Irina, Podolsky, Rebecca L, Podyminogin, Peter S, Askovich, Piper M, Treuting, Alan, Aderem   +6 more
openaire   +2 more sources

Regulation of cholesterol biosynthesis and esterification by 25-hydroxycholesterol in a macrophage-like cell line: uncoupling by progesterone.

Journal of Lipid Research, 1984
The coordinated control of cholesterol biosynthesis and esterification by 25-hydroxycholesterol was studied in the macrophage-like cell line P388D1. Since 25-hydroxycholesterol rapidly stimulated incorporation of [3H]oleate into the cholesteryl ester ...
S C Miller, G Melnykovych
doaj   +1 more source

Se doped ZnO nanoparticles with improved catalytic activity in degradation of Cholesterol [PDF]

Journal of Water and Environmental Nanotechnology, 2018
Pristine and Se doped ZnO nanoparticles (NPs) were successfully synthesized by thermo-mechanical method and their structural, morphological and optical properties are characterized.
Bhavani Nenavathu, Aarti Sharma, Raj Kumar Dutta   +2 more
doaj   +1 more source

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis

Journal of Lipid Research, 2010
Patients with a recessively inherited “pure” hereditary spastic paresis (SPG5) have mutations in the gene coding for the oxysterol 7 α hydroxylase (CYP7B1).
Rebecca Schüle, Teepu Siddique, Han-Xiang Deng, Yi Yang, Sandra Donkervoort, Magnus Hansson, Ricardo E. Madrid, Nailah Siddique, Ludger Schöls, Ingemar Björkhem   +9 more
doaj   +1 more source

In vivo formation of 25-hydroxycholesterol from endogenous cholesterol after a single meal, dietary cholesterol challenge.

Journal of Lipid Research, 1994
The role of oxysterols as regulatory molecules in the suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity was investigated in the intact rat in response to an acute dietary cholesterol challenge.
K A Johnson, C J Morrow, G D Knight, T J Scallen   +3 more
doaj   +1 more source