Results 21 to 30 of about 3,018,278 (209)

Increased 25-hydroxycholesterol as an indicator for patients with vestibular neuritis. [PDF]

Front Neurol
BackgroundVestibular neuritis (VN) is one of the most common diseases in vestibular vertigo. 25-hydroxycholesterol (25-HC) was correlated to neuroinflammation, however, whether the level of serum 25-HC could be used to diagnose the VN occurrence remains unclear.MethodsThe enrolled patients were divided into VN and healthy control groups.
Song X, Liang J, Tian C.
europepmc   +4 more sources

Key regulatory oxysterols in liver: analysis as Δ4-3-ketone derivatives by HPLC and response to physiological perturbations

Journal of Lipid Research, 2001
A number of oxysterols have been implicated in metabolic regulation. Key among these are (24S),25-epoxycholesterol and (24S)-hydroxycholesterol, high affinity ligands for the nuclear transcription factor liver X receptor α; 27-hydroxycholesterol, a bile ...
Zhe Zhang, Dansu Li, Daniel E. Blanchard, Steven R. Lear, Sandra K. Erickson, Thomas A. Spencer   +5 more
doaj   +1 more source

Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells.

Journal of Lipid Research, 1983
The regulation of rabbit intestinal acyl CoA:cholesterol acyltransferase (ACAT) by 25-hydroxycholesterol was studied. 25-Hydroxycholesterol significantly increased jejunal microsomal ACAT activity.
F J Field, S N Mathur
doaj   +1 more source

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The lipid 25-hydroxycholesterol (25HC) is produced by immune cells in response to infection. We demonstrate that in addition to interfering with viral entry and replication, 25HC also amplifies the activation of immune cells and increases the production of immune mediators.
Elizabeth S, Gold, Alan H, Diercks, Irina, Podolsky, Rebecca L, Podyminogin, Peter S, Askovich, Piper M, Treuting, Alan, Aderem   +6 more
openaire   +2 more sources

Are side-chain oxidized oxysterols regulators also in vivo?

Journal of Lipid Research, 2009
Oxsterols are oxygenated metabolites of cholesterol that are short-lived intermediates or end products in cholesterol excretion pathways. They are present in very low concentrations in mammalian systems, always accompanied by a high excess of cholesterol.
Ingemar Bjo¨rkhem
doaj   +1 more source

Oxysterols and Retinal Microvascular Dysfunction as Early Risk Markers for Cardiovascular Disease in Normal, Ageing Individuals

Antioxidants, 2021
The aim of the present paper is to assess the relationship between oxysterol levels and retinal microvascular function in individuals of various age groups, free of clinically evident diseases.
Hala Shokr, Irundika HK Dias, Doina Gherghel   +2 more
doaj   +1 more source

A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. [PDF]

J Neurosci, 2021
Inflammatory cells, including macrophages and microglia, synthesize and release the oxysterol 25-hydroxycholesterol (25HC), which has antiviral and immunomodulatory properties.
Izumi Y, Cashikar AG, Krishnan K, Paul SM, Covey DF, Mennerick SJ, Zorumski CF.   +6 more
europepmc   +2 more sources

Transformation of 25-Hydroxycholesterol by Rhizoctonia muneratii [PDF]

Applied and Environmental Microbiology, 1982
Rhizoctonia muneratii ATCC 13247 was capable of catalyzing the conversion of 25-hydroxycholesterol to the 3-oxo-4-ene. Hydroxylation at the 6α and 6β positions with the concomitant 3-oxo-4-ene transformation was also observed.
M E, Wozny, T R, Smith, R L, Angus, E T, Kaiser   +3 more
openaire   +2 more sources

Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol

Journal of Lipid Research, 1999
25-Hydroxycholesterol negatively regulates cholesterol synthesis and activates cholesterol esterification in a variety of cultured cells. Concurrent with these effects, 25-hydroxycholesterol also stimulates the synthesis of sphingomyelin in Chinese ...
Thomas A. Lagace, David M. Byers, Harold W. Cook, Neale D. Ridgway   +3 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source