, 2021 Miconazole is effective in treating inflammatory skin conditions and has well-established antifungal effects. To elucidate the underlying mechanisms mediating its additional beneficial effects, we assessed whether miconazole influences the inflammation ...
Seong-Kug Eo (3850609) +5 more
core +1 more source
Biosynthesis of the regulatory oxysterol, 5-cholesten-3β,25-diol 3-sulfate, in hepatocytes
Journal of Lipid Research, 2007 Cellular cholesterol homeostasis is maintained through coordinated regulation of cholesterol synthesis, degradation, and secretion. Nuclear receptors for oxygenated cholesterol derivatives (oxysterols) are known to play key roles in the regulation of ...
Xiaobo Li +6 more
doaj +1 more source
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. [PDF]
PLoS ONE, 2017 N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptor mediating excitatory transmission throughout the CNS, participate in ischemia-induced neuronal death.
Min-Yu Sun +3 more
doaj +1 more source
Oncogenic roles of the cholesterol metabolite 25-hydroxycholesterol in bladder cancer. [PDF]
Oncol Lett, 2020 Oxysterols, such as 24S-hydroxycholesterol and 25-hydroxycholesterol are oxidation products of cholesterol generated by enzymatic reactions. The pathological effects of oxysterols have been described in multiple types of cancer, including cancers of the skin, lung, colon, breast and bile ducts.
Wang C, He H, Fang W.
europepmc +4 more sources
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
Journal of Lipid Research, 2009 During screening of genes upregulated by lipopolysaccharide (LPS; endotoxin) treatment of bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-hydroxylase (Ch25h) was strongly upregulated.
Ulf Diczfalusy +7 more
doaj +1 more source
Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol
Journal of Lipid Research, 1999 The abundance of cell cholesterol is governed by multiple regulatory proteins in the endoplasmic reticulum (ER) which, in turn, are under the control of the cholesterol in that organelle.
Yvonne Lange +3 more
doaj +1 more source
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MSs⃞
Journal of Lipid Research, 2009 We describe a highly sensitive and specific method for the quantification of key regulatory oxysterols in biological samples. This method is based upon a stable isotope dilution technique by liquid chromatography-tandem mass spectrometry (LC-MS/MS ...
Akira Honda +8 more
doaj +1 more source
Aggregation of 25-hydroxycholesterol in a complex biomembrane. Differences with cholesterol
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2020 25-Hydroxycholesterol (25HC), one of the most important oxysterol molecules, can be used by cells to fight bacterial and viral infections but the mechanism that defines its biological effects are unknown. Using molecular dynamics, we have aimed to describe the orientation and location of 25HC in the membrane as well as the interactions it might have ...
Galiano, Vicente, Villalaín, José
openaire +3 more sources
Binding of 25-hydroxycholesterol and cholesterol to different cytoplasmic proteins [PDF]
Proceedings of the National Academy of Sciences, 1977 Studies were carried out to determine whether or not oxygenated derivatives of cholesterol (e.g., 25-hydroxycholesterol) that specifically suppress the activity of 3-hydroxy-3-methylglutaryl-CoA reductase [mevalonate:NADP + oxidoreductase (CoA-acylating), EC 1.1.1.34], bind to a soluble component of the cytoplasm ...
Kandutsch, A A, Chen, H W, Shown, E P
openaire +2 more sources