Results 51 to 60 of about 4,298,356 (197)

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind   +17 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Prueba 25 [PDF]

, 2022
PruebaPruebaPruebaMaestríaDoctor en Ingeniería de Sistemas y ...
Prueba 25, Prueba 25
core   +1 more source

Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol

Molecules, 2017
Measles virus (MV) infection is re-emerging, despite the availability of an effective vaccine. The mechanism of MV entry into a target cell relies on coordinated action between the MV hemagglutinin (H) receptor binding protein and the fusion envelope ...
Bárbara Gomes, Nuno C. Santos, Matteo Porotto   +2 more
doaj   +1 more source

Inhibition of cholesterol biosynthesis by 25‐hydroxycholesterol is independent of OSBP [PDF]

Genes to Cells, 2005
25‐hydroxycholesterol (25‐HC) is a potent suppressor of cholesterol synthesis gene transcription in cultured cells. A high affinity binding protein for 25‐HC, oxysterol‐binding protein (OSBP), has been identified from tissue cytosol. OSBP translocates from the cytosol to the Golgi apparatus membranes after addition of 25‐HC to cell cultures and is ...
Taki, Nishimura, Takao, Inoue, Norihito, Shibata, Azusa, Sekine, Wakako, Takabe, Noriko, Noguchi, Hiroyuki, Arai   +6 more
openaire   +2 more sources

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

25-hydroxycholesterol, 7b-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of toll-like receptor 1, 2, 4 or 6 signalling in human macrophages

, 2007
Recent studies have shown that Toll-like receptor (TLR)- signalling contributes significantly to the inflammatory events of atherosclerosis. As products of cholesterol oxidation (oxysterols) accumulate within atherosclerotic plaque and have been proposed
Erridge, Clett, Webb, David J., Spickett, C.M.   +2 more
core   +4 more sources

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Journal of Lipid Research, 2002
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney, Karl Bodin, Ulf Diczfalusy, Ingemar Björkhem   +3 more
doaj   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source