Results 71 to 80 of about 4,298,356 (197)

The Mechanism of HIV Entry Inhibition by 25-Hydroxycholesterol [PDF]

Biophysical Journal, 2016
Among the known biological activities of 25-hydroxycholesterol (25HC) are its potential immunological functions. A recent work demonstrated that 25HC blocks HIV-1 entry, preventing the release of the viral content into the host cell, which suggests an action at the membrane level.The aim of this work is to clarify 25HC antiviral mechanism, studying its
Gomes, Bárbara, Hollmann, Axel, Santos, Nuno C.   +2 more
openaire   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Associations between serum estradiol and estrone and Alzheimer's disease biomarkers: An analysis in female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study (EPAD LCS)

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Postmenopausal estrogen decline may contribute to Alzheimer's disease (AD), but evidence linking circulating estrogens to cerebrospinal fluid (CSF) AD biomarkers remains limited. METHODS We analyzed 854 female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study with baseline serum estradiol ...
Juehyun Shin, Graciela Muniz‐Terrera, Craig W. Ritchie, Jean Manson, Susan Plachecki, Clemens Kirschbaum, Sarah Gregory   +6 more
wiley   +1 more source

Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol

Journal of Lipid Research, 2018
Production of 25-hydroxycholesterol (25HC), a potent inhibitor of viral infection, is catalyzed by cholesterol 25-hydroxylase (CH25H). We previously reported that 25HC induced CH25H expression in a liver X receptor (LXR)-dependent manner, implying that ...
Ying Liu, Zhuo Wei, Ye Zhang, Xingzhe Ma, Yuanli Chen, Miao Yu, Chuanrui Ma, Xiaoju Li, Youjia Cao, Jian Liu, Jihong Han, Xiaoxiao Yang, Yajun Duan   +12 more
doaj   +1 more source

Serum VIP and IL‐1β Levels Are Associated With Anxiety and Depression in Patients With Parkinson's Disease: A Cross‐Sectional Study

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Background Anxiety and depressive symptoms frequently accompany Parkinson's disease (PD), yet the biological processes underlying these affective complications and their potential peripheral indicators remain incompletely understood. This study evaluated whether circulating concentrations of vasoactive intestinal peptide (VIP), interleukin‐1β (
Liangyu Li, Xiaoyang Jia, Ying Shi, Zexin Yuan, Caoyuan Niu, Yujing Huang, Xiaoli Zhang, Honglei Li, Tiantian Han, Yanji Cui, Pengge Fei, Guihua Wang, Ailing Du   +12 more
wiley   +1 more source

25-Hydroxycholesterol-induced elevation in 45Ca uptake: correlation with depressed DNA synthesis.

, 1984
The mechanism whereby 25-hydroxycholesterol, an inhibitor of the synthesis of cholesterol, depresses DNA synthesis in cycling P815 mastocytoma cells was investigated. The uptake of 45Ca into P815 cells treated with 1 microgram/ml 25-hydroxycholesterol
Heiniger, H J, Boissonneault, G A
core   +1 more source

Side chain hydroxylation of cholesterol, campesterol and β-sitosterol in rat liver mitochondria

Journal of Lipid Research, 1976
The extent of the side chain hydroxylation of cholesterol, campesterol (24 α-methylcholesterol), and β-sitosterol (24 α-ethylcholesterol) in rat liver mitochondria has been compared.
L Aringer, P Eneroth, L Nordström
doaj   +1 more source

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 762-773, September 2026.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat, Haribhau Kangne, Rasmus Jansson‐Löfmark, Jens K. Hertel, Amin Rostami‐Hodjegan, Ida Robertsen, Aleksandra Galetin   +6 more
wiley   +1 more source

25-Hydroxycholesterol-induced elevations in 45Ca uptake: permeability changes in P815 cells.

, 1985
Certain oxysterols are capable of suppressing the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase. We have previously demonstrated that treatment of P815 cells with 1 microgram 25-hydroxycholesterol/ml culture results in a rapid ...
Heiniger, H J, Boissonneault, G A
core   +1 more source

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan   +4 more
wiley   +1 more source