Results 81 to 90 of about 3,018,278 (209)
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li +10 more
wiley +1 more source
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol
Journal of Lipid Research, 2018 Production of 25-hydroxycholesterol (25HC), a potent inhibitor of viral infection, is catalyzed by cholesterol 25-hydroxylase (CH25H). We previously reported that 25HC induced CH25H expression in a liver X receptor (LXR)-dependent manner, implying that ...
Ying Liu +12 more
doaj +1 more source
Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome
Epilepsia, Volume 67, Issue 6, Page 2796-2807, June 2026.Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan +14 more
wiley +1 more source
25-hydroxycholesterol impairs neuronal and muscular development in zebrafish
NeuroToxicology, 2019 Oxysterols have essential effects on brain homeostasis and their levels are often altered in neurodegenerative and neuroinflammatory diseases. Several studies have demonstrated the cytotoxic effects of 25-HC on different cell lines, however, not much is known about its effects on neurons in vivo. In this study, we examined the effects of 25-HC exposure
Jamadagni, Priyanka +1 more
openaire +3 more sources
On the substrate specificity of human CYP27A1
Journal of Lipid Research, 2003 The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin +3 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Enteromorpha prolifera polysaccharides may help restore lipid metabolism homeostasis by gently remodeling the gut microbiota to enrich beneficial bacteria and SCFAs, which in turn appears to modulate hepatic functions through the portal vein by downregulating cholesterol synthesis and promoting its metabolism. This coordinated process potentially leads
Liuying Zhu +5 more
wiley +1 more source
, 1991 Congrés realitzat pel Canal 25 que tracta sobre com ha sigut la inversió tecnològica a les escoles amb feedback per part de l'estudiant i ...
Canal 25 (25 Televisió)
core
, 1995 The major relation existing between cell growth and cholesterol homeostasis prompted us to investigate the effect of 26-aminocholesterol (26-NH2), 27-hydroxycholesterol (27-OH), and 25-hydroxycholesterol (25-OH) on these cellular events.
R. Paoletti +5 more
core +1 more source
Separations, 2018 Oxysterols are metabolites produced in the first step of cholesterol metabolism, which is related to neurodegenerative disorder. They can be detected by testing blood, plasma, serum, or cerebrospinal fluid.
Lucia Valverde-Som +7 more
doaj +1 more source
Changes in the gut microbiome during fasting‐induced molting and its effects on gut–liver function
iMetaOmics, Volume 3, Issue 2, June 2026.During fasting, harmful microbiota and metabolites rise, triggering intestinal injury and activation of the TGF‐β signaling pathway, which enhances intestinal stem cell proliferation. Concurrently, hepatic function declines, indicated by increased hepatic and serum bile acids and upregulation of the non‐classical bile acid synthesis pathway.
Hao Zhang +11 more
wiley +1 more source