Results 11 to 20 of about 7,256 (187)
ChemistryEuropeAerobic oxidation to insert oxygen functional groups into the CD ring of the steroid framework was investigated using several 5,6‐α‐epoxysterol precursors. Oxidation under Schenck‐ene conditions provided oxysterols with a hydroxyl group at either C8, C9,
Hinata Togo, Yui Kanda, Shoji Kobayashi
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Oxysterols and retinal degeneration [PDF]
British Journal of Pharmacology, 2021 Retinal degeneration, characterised by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate cholesterol homeostasis in the retina.
Zhang, Xun +6 more
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Oxysterols and Oxysterol Sulfates in Alzheimer’s Disease Brain and Cerebrospinal Fluid [PDF]
Journal of Alzheimer's Disease, 2022 Background: Brain cholesterol levels are tightly regulated but increasing evidence indicates that cholesterol metabolism may drive Alzheimer’s disease (AD)-associated pathological changes. Recent advances in understanding of mitochondrial dysfunction in AD brain have presented a vital role played by mitochondria in oxysterol biosynthesis and their ...
Dias, Irundika H K +3 more
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Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]
J NeurochemBrain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc +2 more sources
Oxysterols: A world to explore [PDF]
Food and Chemical Toxicology, 2010 Oxysterols (oxidized derivatives of cholesterol and phytosterols) can be generated in the human organism through different oxidation processes, some requiring enzymes. Furthermore, oxysterols are also present in food due to lipid oxidation reactions caused by heating treatments, contact with oxygen, exposure to sunlight, etc., and they could be ...
Astiasarán, I. (Iciar) +3 more
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Frontiers in Nutrition, 2022 Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols.
Federico Canzoneri +5 more
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CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination. [PDF]
CNS Neurosci TherOur findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Li L +10 more
europepmc +2 more sources
Multiple Targets for Oxysterols in Their Regulation of the Immune System
Cells, 2021 Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system.
Lisa Reinmuth +4 more
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Mechanisms of oxysterol-induced carcinogenesis
Lipids in Health and Disease, 2011 Oxysterols are oxidation products of cholesterol that are generated by enzymatic reactions mediated by cytochrome P450 family enzymes or by non-enzymatic reactions involving reactive oxygen and nitrogen species.
Loilome Watcharin +4 more
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Oxysterols and Their Cellular Effectors [PDF]
Biomolecules, 2012 Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain organization, and packing of membrane lipids.
Olkkonen, Vesa M. +2 more
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