Results 11 to 20 of about 2,722,655 (194)

Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice. [PDF]

Biosci Rep, 2018
Sterol 27-hydroxylase (CYP27A1) catalyzes the hydroxylation of cholesterol to 27-hydroxycholesterol (27-OHC) and regulates cholesterol homeostasis. In Cyp27a1/ Apolipoprotein E (ApoE) double knockout (KO) mice fed with Western diet (WD), the atherosclerotic phenotype found in ApoE KO mice was reversed.
Zurkinden L, Sviridov D, Vogt B, Escher G.   +3 more
europepmc   +9 more sources

Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo [PDF]

Journal of Endocrinology, 2013
The intracellular availability of glucocorticoids is regulated by the enzymes 11β-hydroxysteroid dehydrogenase 1 (HSD11B1) and 11β-hydroxysteroid dehydrogenase 2 (HSD11B2). The activity of HSD11B1 is measured in the urine based on the (tetrahydrocortisol+5α-tetrahydrocortisol)/tetrahydrocortisone ((THF+5α-THF)/THE) ratio in humans ...
Vögeli, Isabelle, Jung, Hans H, Dick, Bernhard, Erickson, Sandra K, Escher, Robert, Funder, John W, Frey, Felix J, Escher, Geneviève   +7 more
openaire   +6 more sources

Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1996
The study objective was to determine whether and to what extent sterol 27-hydroxylase, the initial step in the "acidic" pathway of bile acid biosynthesis, is regulated by bile acids. Rats were fed diets supplemented with cholestyramine (CT, 5%), cholate (CA, 1%), chenodeoxycholate (CDCA, 1%), or deoxycholate (DCA, 0.25%).
Z R, Vlahcevic, S K, Jairath, D M, Heuman, R T, Stravitz, P B, Hylemon, N G, Avadhani, W M, Pandak   +6 more
openaire   +3 more sources

Sterol 27-Hydroxylase Acts on 7-Ketocholesterol in Human Atherosclerotic Lesions and Macrophages in Culture [PDF]

Journal of Biological Chemistry, 2000
27-Hydroxycholesterol (27OH) is the major oxysterol in human atherosclerotic lesions, followed by 7-ketocholesterol (7K). Whereas 7K probably originates nonenzymically, 27OH arises by the action of sterol 27-hydroxylase, a cytochrome P450 enzyme expressed at particularly high levels in the macrophage and proposed to represent an important pathway by ...
Brown, Andrew J., Watts, Gerald F., Burnett, John R., Dean, Roger T., Jessup, Wendy K.   +4 more
openaire   +4 more sources

Exon skipping in the sterol 27-hydroxylase gene leads to cerebrotendinous xanthomatosis [PDF]

Human Genetics, 1997
We report a new mutation in the sterol 27-hydroxylase (CYP 27) gene in a Dutch family with cerebrotendinous xanthomatosis: a G-->A transition in the splice donor site in intron 4. This mutation leads to skipping of exon 4, resulting in a loss of 66 amino acids in the CYP 27 enzyme molecule.
Verrips, A., Steenbergen-Spanjers, G.C.H., Luyten, J.A.F.M., Wevers, R.A., Wokke, J.H.J., Gabreëls, F.J.M., Wolthers, B.G., Heuvel, L.P.W.J. van den   +7 more
openaire   +7 more sources

Sterol 27-hydroxylase: high levels of activity in vascular endothelium.

Journal of Lipid Research, 1994
Sterol 27-hydroxylase activity in bovine aortic endothelial (BAE) cells in culture has been compared with that in HepG2 cells and in Chinese hamster ovary (CHO) cells using identical culture conditions. The total enzyme activity of BAE cells (3.0 nmol/72
A B Reiss, K O Martin, N B Javitt, D W Martin, E A Grossi, A C Galloway   +5 more
doaj   +3 more sources

Cerebrotendinous xanthomatosis caused by two new mutations of the sterol-27-hydroxylase gene that disrupt mRNA splicing.

Journal of Lipid Research, 1996
Cerebrotendinous xanthomatosis (CTX) is an inherited sterol storage disease associated with the accumulation of cholestanol and cholesterol in various tissues.
R Garuti, N Lelli, M Barozzini, R Tiozzo, M T Dotti, A Federico, A M Ottomano, A Croce, S Bertolini, S Calandra   +9 more
doaj   +3 more sources

Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus. [PDF]

Journal of Clinical Investigation, 1995
We investigated the lobular localization and molecular level of expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase, two key enzymes in bile acid synthesis, in isolated periportal and pericentral hepatocytes and by in situ hybridization of rat liver.
Twisk, J., Hoekman, M.F.M., Mager, W.H., Moorman, A.F.M., Boer, P.A.J. de, Scheja, L., Princen, H.M.G., Gebhardt, R.   +7 more
openaire   +6 more sources

Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1 [PDF]

Biochemical Journal, 2003
The mitochondrial sterol 27-hydroxylase (CYP27A1) is a multifunctional cytochrome P450 enzyme that catalyses important hydroxylations in the biosynthesis of bile acids and bioactivation of vitamin D3. Previous results [Babiker, Andersson, Lund, Xiu, Deeb, Reshef, Leitersdorf, Diczfalusy and Björkhem (1997) J. Biol. Chem.
Zufan, Araya, Wanjin, Tang, Kjell, Wikvall   +2 more
openaire   +3 more sources

Studies on sterol 27-hydroxylase (CYP27A1)

, 2004
Human sterol 27-hydroxylase (CYP27A1) has been studied in the present thesis with focus on substrate specificity and possible role of the enzyme for prevention of accumulation of cholesterol and cholestanol in tissues. Attempts have been made to evaluate a metabolic pathway to bile acids in human primary hepatocytes that starts with a 27-hydroxylation ...
Sara von Bahr (19525159)
core   +3 more sources