Results 11 to 20 of about 2,010 (126)

Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene [PDF]

BMC Genetics, 2006
Background Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol and bile acids, including ...
Wan Yu-Jui, Klaassen Curtis D, Guo Grace L, Jenison Robert D, Wang Shuang, Nakamoto Kaori, Zhong Xiao-bo   +6 more
doaj   +3 more sources

Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1–AKT–mTOR Axis in MiceSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Hepatic cholesterol accumulation and autophagy defects contribute to hepatocyte injury in fatty liver disease. Bile acid synthesis is a major pathway for cholesterol catabolism in the liver.
Yifeng Wang, Yifeng Ding, Jibiao Li, Hemantkumar Chavan, David Matye, Hong-Min Ni, John Y.L. Chiang, Partha Krishnamurthy, Wen-Xing Ding, Tiangang Li   +9 more
doaj   +2 more sources

MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1

Cellular & Molecular Biology Letters, 2018
Background The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal event in the initiation and ...
Ruijie Gong, Xiaofei Lv, Fengqiong Liu
doaj   +2 more sources

Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1

Frontiers in Physiology, 2018
Intrauterine growth restriction (IUGR) and consumption of a high saturated fat diet (HFD) increase the risk of hypercholesterolemia, a leading cause of morbidity and mortality.
Erin K. Zinkhan, Baifeng Yu, Amnon Schlegel, Amnon Schlegel, Amnon Schlegel, Amnon Schlegel   +5 more
doaj   +2 more sources

Cholesterol 7 alpha-hydroxylase (CYP7A1) gene polymorphisms are associated with increased LDL-cholesterol levels and the incidence of subclinical atherosclerosis [PDF]

Biomolecules & Biomedicine
The cholesterol 7 alpha-hydroxylase (CYP7A1) enzyme plays an important role in the conversion of cholesterol to bile acid, contributing to the reduction of cholesterol plasma levels in normal conditions.
Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez, Oscar Peréz-Méndez, José Manuel Fragoso   +3 more
doaj   +2 more sources

Identification of Genetic Markers of APOM and CYP7A1 Genes Affecting Milk Production Traits in Chinese Holstein

Agriculture
Our previous study identified the apolipoprotein M (APOM) and cytochrome P450 family 7 subfamily A polypeptide 1 (CYP7A1) genes as candidates for milk traits in dairy cattle, which were significantly up-regulated in liver tissue of Holstein cows between ...
Yanan Liu, Zijiao Guo, Junqing Ni, Chendong Yang, Bo Han, Yabin Ma, Jianming Li, Guie Jiang, Weijie Zheng, Dongxiao Sun   +9 more
doaj   +2 more sources

Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism

Journal of Pharmacy and Bioallied Sciences, 2011
It is well known that drug disposition and response are greatly determined by the activities of drug metabolizing enzymes, which are polymorphic.
Vera Dias, V Ribeiro
doaj   +2 more sources

Polymorphisms of CYP7A1 and HADHB Genes and Their Effects on Milk Production Traits in Chinese Holstein Cows

Animals
Our preliminary research proposed the cytochrome P450 family 7 subfamily A member 1 (CYP7A1) and hydroxyacyl-coenzyme A dehydrogenase trifunctional multienzyme complex beta subunit (HADHB) genes as candidates for association with milk-production traits ...
Ao Chen, Qianyu Yang, Wen Ye, Lingna Xu, Yuzhan Wang, Dongxiao Sun, Bo Han   +6 more
doaj   +2 more sources

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids

, 2005
The gene encoding cholesterol 7α-hydroxylase (CYP7A1) is tightly regulated in order to control intrahepatic cholesterol and bile acid levels. Ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression. To retrace the evolution of the
Handschin, Christoph, Meyer, Urs A., Gnerre, Carmela, Fraser, David J., Jover Atienza, Ramiro, Martinez Jimenez, Celia Pilar   +5 more
core   +2 more sources

A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor–liver crosstalk in causing adverse effects on the host

Disease Models & Mechanisms, 2018
The nature of host organs and genes that underlie tumor-induced physiological disruption on the host remains ill-defined. Here, we establish a novel zebrafish intestinal tumor model that is suitable for addressing this issue, and find that hepatic cyp7a1,
Sora Enya, Koichi Kawakami, Yutaka Suzuki, Shinpei Kawaoka, Almut Schulze, Mariia Yuneva   +5 more
doaj   +1 more source