Results 21 to 30 of about 2,010 (126)

Analysis of CYP7A1 gene regulation in HepG2 cells by reverse-transcriptase polymerase chain reaction [PDF]

, 1997
grantor: University of TorontoThe conversion of cholesterol to bile acids is the major quantitative pathway through which cholesterol is removed from the body.
Andreou, Efrosini Roseann
core   +2 more sources

Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy

Archives of Medical Science, 2018
Introduction Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism.
Ahter Tanay Tayyar, Ahmet Tayyar, Sukran Kozali, Resul Karakus, Nadiye Koroglu, Ilkbal Temel Yuksel, Gonca Yetkin Yildirim, Ismail Dag, Mustafa Eroglu   +8 more
doaj   +1 more source

CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1) [PDF]

, 2010
Review on CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1), with data on DNA, on the protein encoded, and where the gene is ...
Norlin, M, K Wikvall, Wikvall, K, M Norlin   +3 more
core   +1 more source

Association of CYP7A1 and CYP2E1 Polymorphisms with Type 2 Diabetes in the Chinese Han Populations

Pharmacogenomics and Personalized Medicine, 2022
Lihong Zhang, Jingjing Tang, Yindi Wang, Xiang Wang, Fang Wang Department of Endocrinology, Xi’an Central Hospital Affiliated to Xi’an Jiaotong University, Xi’an, 710003, People’s Republic of ChinaCorrespondence: Fang Wang, Department of Endocrinology ...
Zhang L, Tang J, Wang Y, Wang X, Wang F
doaj  

Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid[S]

Journal of Lipid Research, 2019
All-trans retinoic acid (atRA) is used to treat certain cancers and dermatologic diseases. A common adverse effect of atRA is hypercholesterolemia; cytochrome P450 (CYP) 7A repression is suggested as a driver. However, the underlying molecular mechanisms
Kyoung-Jae Won, Joo-Seop Park, Hyunyoung Jeong   +2 more
doaj   +1 more source

Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids

Journal of Lipid Research, 2001
Hydrophobic bile acids strongly repressed transcription of the human cholesterol 7α-hydroxylase gene (CYP7A1) in the bile acid biosynthetic pathway in the liver. Farnesoid X receptor (FXR) repressed CYP7A1/Luc reporter activity in a transfection assay in
Wenling Chen, Erika Owsley, Yizeng Yang, Diane Stroup, John Y.L. Chiang   +4 more
doaj   +1 more source

Down-Regulation of Lnc-CYP7A1-1 Rejuvenates Aged Human Mesenchymal Stem Cells to Improve Their Efficacy for Heart Repair Through SYNE1

Frontiers in Cell and Developmental Biology, 2020
BackgroundSeveral long non-coding RNAs (lncRNAs) have been associated with cell senescence, termed senescence-associated lncRNAs (SAL-RNAs). However, the mechanisms involved for SAL-RNAs in aging are not fully elucidated.
Jun Dong, Jun Dong, Jianwei Liu, Yueqiang Wen, Stephanie W. Tobin, Chongyu Zhang, Chongyu Zhang, Huiling Zheng, Zehan Huang, Yongtao Feng, Yongtao Feng, Dongcheng Zhang, Dongcheng Zhang, Shiming Liu, Zhenhui Zhang, Jiao Li, Jiao Li   +16 more
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Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome. [PDF]

, 2020
Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. Cyp27a1/Apolipoprotein E double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis via up ...
Sviridov, Dmitri, Zurkinden, Line, Vogt, Bruno, Escher, Genevieve   +3 more
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Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding

Journal of Lipid Research, 2001
Bile acids are synthesized via the classic pathway initiated by cholesterol 7α-hydroxylase (CYP7A1), and via alternate pathways, one of which is initiated by sterol 27-hydroxylase (CYP27).
Margrit Schwarz, David W. Russell, John M. Dietschy, Stephen D. Turley   +3 more
doaj   +1 more source

A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins

Frontiers in Genetics, 2023
Background and Aims: Various publications suggested that there is an association between CYP7A1 single nucleotide polymorphisms (SNP) and a reduced response to statin therapy, but the results were inconsistent.
Megan Yu Cai Lim, Jia Rong Tee, Wai-Ping Yau, Han Kiat Ho   +3 more
doaj   +1 more source