Results 31 to 40 of about 2,010 (126)

CYP7A1 promoter polymorphism −203A>C affects bile salt synthesis rate in patients after ileal resection

Journal of Lipid Research, 2008
Cholesterol 7α-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance.
Martin Leníček, Viktor Komárek, Miluše Zimolová, Jan Kovář, Milan Jirsa, Milan Lukáš, Libor Vítek   +6 more
doaj   +1 more source

PGC-1 alpha activates CYP7A1 and bile acid biosynthesis

, 2003
Cholesterol 7-alpha-hydroxylase (CYP7A1) is the key enzyme that commits cholesterol to the neutral bile acid biosynthesis pathway and is highly regulated. In the current studies, we have uncovered a role for the transcriptional co-activator PGC-1alpha in
Osborne, Timothy F., Gil, Gregorio, Shin, Dong-Ju, Campos-Sandoval, José Ángel   +3 more
core   +1 more source

A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice[S]

Journal of Lipid Research, 2011
Cholesterol 7α-hydroxylase (CYP7A1) encodes for the rate-limiting step in the conversion of cholesterol to bile acids in the liver. In response to acute cholesterol feeding, mice upregulate CYP7A1 via stimulation of the liver X receptor (LXR) α. However,
Anne S. Henkel, Kristy A. Anderson, Amanda M. Dewey, Mark H. Kavesh, Richard M. Green   +4 more
doaj   +1 more source

Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis

, 2001
The initial and rate-limiting step in the classic pathway of bile acid biosynthesis is 7α-hydroxylation of cholesterol, a reaction catalyzed by cholesterol 7α-hydroxylase (CYP7A1).
W. M. Pandak, P. B. Hylemon, D. Mallonee, C. Schwarz, Kaye Redford, Z. R. Vlahcevic, D. M. Heuman, K. Valerie, R. A. Fisher   +8 more
core   +1 more source

Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene [PDF]

, 2016
Aim To determine whether the promoter polymorphism -203A>C of cholesterol-7α-hydroxylase encoding gene (CYP7A1) affects diurnal variation in CYP7A1 enzyme activity.
Miluše Vlachová, Věra Lánská, Jan Piťha, Martin Leníček, Vítek, Libor, Piťha, Jan, Libor Vítek, Kovář, Jan, Vlachová, Miluše, Jan Kovář, Blahová, Tereza, Tereza Blahová, Lánská, Věra, Leníček, Martin   +13 more
core   +1 more source

Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice

Journal of Lipid Research, 2003
Cholesterol 7α-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and is highly
Sandra K. Erickson, Steven R. Lear, Sean Deane, Sandrine Dubrac, Sandra L. Huling, Lien Nguyen, Jaya S. Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Benjamin Shneider, Ephraim Sehayek, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Fredrick J. Suchy, Ashok K. Batta, Gerald Salen   +16 more
doaj   +1 more source

Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice

Journal of Lipid Research, 2017
The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1α/X-box binding protein 1 (IRE1α/XBP1) pathway of the UPR is important in lipid metabolism.
Xiaoying Liu, Anne S. Henkel, Brian E. LeCuyer, Susan C. Hubchak, Matthew J. Schipma, Eric Zhang, Richard M. Green   +6 more
doaj   +1 more source

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

Journal of Lipid Research, 2007
Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene, encoding the rate-limiting enzyme in the classic bile acid synthesis pathway ...
Insook Kim, Sung-Hoon Ahn, Takeshi Inagaki, Mihwa Choi, Shinji Ito, Grace L. Guo, Steven A. Kliewer, Frank J. Gonzalez   +7 more
doaj   +1 more source

Ferulic acid attenuates high-fat diet-induced hypercholesterolemia by activating classic bile acid synthesis pathway

Frontiers in Nutrition, 2022
Ferulic acid (FA), a natural phenolic phytochemical abundantly present in whole grains, displays promising therapeutic effects on hypercholesterolemia while its underlying mechanism not fully elucidated.
Zhixin Luo, Mengqian Li, Jiachuan Yang, Jia Li, Yao Zhang, Fang Liu, Emad El-Omar, Lin Han, Ji Bian, Lan Gong, Min Wang   +10 more
doaj   +1 more source

Significance and Mechanism of CYP7a1 Gene Regulation during the Acute Phase of Liver Regeneration

, 2009
Cholesterol 7α-hydroxylase (CYP7a1) is the rate-limiting enzyme in the classic pathway of bile acid synthesis. Expression of CYP7a1 is regulated by a negative feedback pathway of bile acid signaling.
Huang, Xiongfei, Meng, Zhipeng, Zhang, Lisheng, Huang, Wendong, Dong, Bingning, Shiah, Steven, Moore, David D   +6 more
core   +1 more source