Results 51 to 60 of about 2,010 (126)
, 2023 Background and Aims: Various publications suggested that there is an association between CYP7A1 single nucleotide polymorphisms (SNP) and a reduced response to statin therapy, but the results were inconsistent.
Megan Yu Cai Lim (16242260) +7 more
core +1 more source
JSFA reports, EarlyView.Abstract The dietary and lifestyle practices have predominantly compromised human health, which are influenced by modernization and industrialization. Hypercholesterolemia, caused by the consumption of fatty and fried foods and a sedentary lifestyle, is a major modifiable risk factor for cardiovascular disease and commonly coexists with obesity ...
Muhammad Usman Khalid +8 more
wiley +1 more source
Journal of Lipid Research, 2013 It has been proposed that bile acid suppression of CYP7A1 gene expression is mediated through a gut-liver signaling pathway fibroblast growth factor (FGF)15/19-fibroblast growth factor receptor 4 which is initiated by activation of farnesoid X receptor ...
Quan Shang +5 more
doaj +1 more source
JEADV Clinical Practice, EarlyView.Chronic kidney disease‐associated pruritus (CKDaP) is a frequent complication of advanced CKD with an incompletely understood pathophysiology. We identified a significantly altered glycine‐to‐taurine conjugated bile acid ratio in patients with CKDaP despite unchanged total serum bile acid concentrations.
Miriam M. Düll +6 more
wiley +1 more source
Role of the cholesterol 7α- hydroxylase and CYP7A1 gene in human physiology and pathology [PDF]
, 2010 Cholesterol 7α- hydroxylase (CYP7A1) belongs to the big family of cytochrome p450. Biological significance of cholesterol 7α- hydroxylase is associated with beginning of cholesterol transformation to the bile acids.
Żak, Iwona +2 more
core
Expression of Cyp7a1 transcription regulators in liver and ileum.
, 2015 The mRNAs of key factors that regulate basal Cyp7a1 transcription (HNF4α, LRH-1, and PGC-1α) and BA-feedback inhibition of Cyp7a1 transcription (both FXR-SHP in liver and FXR-Fgf15 in ileum) were quantified in (A) liver and (B) intestine.
Curtis D. Klaassen (131598) +2 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source
Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine
Phytotherapy Research, EarlyView.By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao +11 more
wiley +1 more source
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes
British Journal of Pharmacology, EarlyView.Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley +1 more source