Results 71 to 80 of about 2,010 (126)

To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux

Frontiers in Medicine
Aim of the studyTo investigate the effect of Ruanjian Qingmai granules (RJQM) on arteriosclerotic obliterans (ASO) and identify its potential bioactive components.Materials and methodsSeparate zebrafish atherosclerosis models and cellular lipid ...
Chenglin Jia, Biying Hong, Yujie Jiang, Chao Ma, Wei Liu, Wei Liu, Wei Liu, Yicheng Xu, Jian Chen, Yan Xie, Yan Xie, Yan Xie, Guangbo Ge, Guangbo Ge, Guangbo Ge, Ye-min Cao, Tianhua Yan, Yongbing Cao   +17 more
doaj   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

Prox1 co-localizes with LSD1/NuRD complex components on CYP7A1 promoter.

, 2013
(A) Occupancy of HNF4α, Prox1, and LSD1/NuRD components on CYP7A1 promoter in HepG2 cells. Chromatin immunoprecipitation (ChIP) was performed on chromatin fragments prepared from HepG2 cells using specific antibodies as indicated and corresponding normal
Huafang Ouyang (405865), Youhua Xie (405867), Yanfeng Liu (405866), Yi Qin (115337), Jing Liu (38537)   +4 more
core   +1 more source

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms

Journal of Lipid Research, 2010
Cholesterol 7α-hydroxylase (CYP7A1) plays a key role in maintaining lipid and bile salt homeostasis as it is the rate-limiting enzyme converting cholesterol to bile acids. Deficiency of CYP7A1 leads to hyperlipidemia in man and mouse.
Shi-Ying Cai, Hongwei He, Trong Nguyen, Albert Mennone, James L. Boyer   +4 more
doaj   +1 more source

A 5:2 Intermittent Fasting Regimen Ameliorates High‐Fat Diet‐Induced MASLD‐Associated Skeletal Muscle Impairment in Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Metabolic dysfunction–associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disorder worldwide. Its pathogenesis is closely linked to high‐fat diets (HFDs) and is frequently accompanied by decreased skeletal muscle quality.
Ruohua Wang, Rui Yang, Dan Hu, Tonghe Xin, ZiXin Yang, Yue Guan, Yucun Niu   +6 more
wiley   +1 more source

AMPK phosphorylation due to MIC-1 plays a critical role in CYP7A1 and HMGCR downregulation.

, 2023
Representative western blots and their densitometric analyses showing cholesterol 7α-hydroxylase (CYP7A1) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression levels in (A) Hep3B cells treated with 5 or 20 ng/ml MIC-1, (B) Hep3B cells treated ...
Su-Jeong Kim (577189), Woo-Jae Park (3604772), Inkeun Park (3044577), Yun-Jae Jung (16324664), Eun-Ji Lee (381840), Min Hee Kim (8321232)   +5 more
core   +1 more source

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression

, 2015
Bile acids are primarily synthesized from cholesterol in the liver and have important roles in dietary lipid absorption and cholesterol homoeostasis. Detailed roles of the orphan nuclear receptors regulating cholesterol 7α-hydroxylase (CYP7A1), the rate ...
Chul Ho Lee, J Y L Chiang, I K Lee, S B Park, H S Choi, W I Jeong, J M Lee, S H Kim, D K Kim, Y Zhang   +9 more
core   +1 more source

Bile Acid Metabolism as a Unifying Readout for Diet, Microbiome Function, and Gastrointestinal Disease

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Dietary components shape the gut microbiome, which modifies bile acids through transformations. The resulting bile acid pool is sensed by host receptors to regulate immunity, metabolism, and intestinal function. Targeted bile acid measurements provide a unifying readout to study diet‐microbiome interactions and to develop next‐generation dietary ...
Jason Dichter
wiley   +1 more source