Results 91 to 100 of about 2,010 (126)

Additional file 3: of MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1

, 2018
Figure S2. A – CYP7A1 is predicted to be a target of miR-17 in humans. B – CYP7A1 is predicted to be a target of miR-17 in mice.
Fengqiong Liu (717705), Ruijie Gong (5118944), Xiaofei Lv (409015)   +2 more
core   +1 more source

Risk Modification of Colorectal Adenoma by CYP7A1 Polymorphisms and the Role of Bile Acid Metabolism in Carcinogenesis

, 2012
Cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, is a postulated gene modifier of colorectal cancer risk and target for the therapeutic bile acid, ursodeoxycholic acid (UDCA).
Changming Fang, Jeffrey W. Smith, Patricia A. Thompson, David S. Alberts, Betsy C. Wertheim, Peter Lance   +5 more
core   +1 more source

Liver Receptor Homolog-1 Is Critical for Adequate Up-regulation of Cyp7a1 Gene Transcription and Bile Salt Synthesis During Bile Salt Sequestration

, 2011
Liver receptor homolog-1 (LRH-1) is a nuclear receptor that controls a variety of metabolic pathways. In cultured cells, LRH-1 induces the expression of CYP7A1 and CYP8B1, key enzymes in bile salt synthesis.
Havinga, Rick, Albert K. Groen, Gerrits, Han, Carolien Out, Hageman, Jurre, Martin J. Smit, Rick Havinga, Folkert Kuipers, Gelpke, Maarten D. Sollewijn, Kuipers, Folkert, Out, Carolien, Smit, Martin J., Trijnie Bos, Kuipers, Folkert; id_orcid, Maarten D. Sollewijn Gelpke, Bos, Trijnie, Groen, Albert K., Han Gerrits, Vincent W. Bloks, Jurre Hageman, Bloks, Vincent W.   +20 more
core   +1 more source

Direct Molecular Action of Taurine on Hepatic Gene Expression Associated with the Amelioration of Hypercholesterolemia in Rats

Antioxidants
Taurine can ameliorate hypercholesterolemia by facilitating cholesterol efflux and increasing cytochrome P450 7A1 (CYP7A1) without clear underlying molecular mechanisms.
Qi Song, Satoru Kobayashi, Yutaro Kataoka, Hiroaki Oda   +3 more
doaj   +1 more source

Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7α-hydroxylase (CYP7A1) transcription.

, 2012
Chlamydia pneumoniae and human cytomegalovirus (HCMV) are intracellular pathogens able to infect hepatocytes, causing an increase in serum triglycerides and cholesterol levels due to the production of inflammatory cytokines. We investigated whether these
RODA, ALDO, ALDINI, RITA, MONTAGNANI, MARCO, Zvi IB, CEVENINI, LUCA, NARDINI, PAOLA, MEZZANOTTE, LAURA, DONATI, MANUELA, MICHELINI, ELISA, MARANGONI, ANTONELLA, FOSCHI, CLAUDIO, Cevenini M, CEVENINI, ROBERTO   +12 more
core   +1 more source

FOXP3 and cholesterol 7α-hydroxylase variants: unraveling genetic links to multiple sclerosis and neuromyelitis optica

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating disorders of the central nervous system. The FOXP3 (rs3761547) and CYP7A1 (rs3808607) polymorphisms together with vitamin D are thought to play a significant ...
Aya Amir Nassef, Hebattalah Monir Mohammed Selim, Nevin Mohieldin Shalaby, Asmaa Ahmed Abdelrasool, Hend Hamed Tamim   +4 more
doaj   +1 more source

A model of Cyp7a1 regulation by H-P/C-HF feeding.

, 2012
Graphic illustration of a network of transcription regulators and Cyp7a1 in the H-P/C-HF group compared with the L-P/C/HF group after 2-d (A) and 4-wk (B) of treatment.
Marie-Camille Zwahlen (122288), Long Wang (95893), Sylviane Metairon (122280), Chieh Jason Chou (122302), Andreas Fuerholz (122295), Martin Kussmann (122292), Robert Mansourian (122284), Frédéric Raymond (51256), Mireille Moser (122275), Katherine Macé (122298)   +9 more
core   +1 more source

Hepatic Cyp7a1 mRNA expression Cftr knockout mice (Cftr^-/-) and controls, fed a control diet or a cholic acid (CA) containing diet for 3 weeks.

, 2016
Hepatic Cyp7a1 mRNA expression after a control (A) or 0.5%-CA (wt/wt) chow diet (B) for three weeks. Cyp7a1 mRNA levels were normalized to a housekeeping gene (β-actin) in Cftr knockout mice (Cftr-/-) and control littermates (Cftr+/+). Data are presented
Henkjan J. Verkade (471026), Marcel J. Bijvelds (2217526), Juul F. W. Baller (2217529), Annette S. H. Gouw (523242), Hugo R. de Jonge (292256), Willemien de Vries (2217520), Frank A. J. A. Bodewes (2217523)   +6 more
core   +1 more source

Image_3_Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1.PDF

, 2018
Intrauterine growth restriction (IUGR) and consumption of a high saturated fat diet (HFD) increase the risk of hypercholesterolemia, a leading cause of morbidity and mortality.
Amnon Schlegel (378366), Baifeng Yu (5306669), Erin K. Zinkhan (5306672)   +2 more
core   +1 more source

Image_1_Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1.TIF

, 2018
Intrauterine growth restriction (IUGR) and consumption of a high saturated fat diet (HFD) increase the risk of hypercholesterolemia, a leading cause of morbidity and mortality.
Amnon Schlegel (378366), Baifeng Yu (5306669), Erin K. Zinkhan (5306672)   +2 more
core   +1 more source