Results 81 to 90 of about 2,010 (126)

Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease

, 2018
Aims Myocardial infarction (MI) and gallstone disease (GSD) are intrinsically linked via cholesterol metabolism. We tested the hypothesis that genetic variants in the gene encoding cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the
Tybjærg-Hansen, Anne, Kofoed, Klaus F., Nordestgaard, Børge G., Frikke-Schmidt, Ruth, Qayyum, Faiza, Lauridsen, Bo K., Ruth Frikke-Schmidt, Børge G Nordestgaard, Faiza Qayyum, Bo K Lauridsen, Klaus F Kofoed, Anne Tybjærg-Hansen   +11 more
core   +1 more source

Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL

Journal of Lipid Research, 2002
Unlike macrophages, the hepatic parenchymal cells express cholesterol-7α-hydroxylase (CYP7A1) which regulates the conversion of cholesterol into bile acids, the major quantitative pathway maintaining cholesterol homeostasis.
Gina L. Moore, Roger A. Davis
doaj   +1 more source

Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

Journal of Lipid Research, 2004
There are two major pathways of bile acid synthesis: the “neutral” pathway, initiated by highly regulated microsomal cholesterol 7α-hydroxylase (CYP7A1), and an “alternative” pathway, initiated by mitochondrial sterol 27-hydroxylase (CYP27A1).
Shunlin Ren, Phillip Hylemon, Dalila Marques, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak   +6 more
doaj   +1 more source

Polyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review

, 2019
Atherosclerosis, the main contributor to coronary heart disease, is characterised by an accumulation of lipids such as cholesterol in the arterial wall.
Paul A. Kroon, Karen F. Chambers, Hassan T. Aboufarrag, Priscilla E. Day   +3 more
core   +1 more source

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders[S]

Journal of Lipid Research, 2016
Cholesterol 7α-hydroxylase (CYP7A1) is the first and rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. In addition to absorption and digestion of nutrients, bile acids play a critical role in the regulation of lipid ...
Jessica M. Ferrell, Shannon Boehme, Feng Li, John Y.L. Chiang   +3 more
doaj   +1 more source

Additional file 5: of MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1

, 2018
Figure S3. Luciferase activity changed in mouse psiCHECK-CYP7A1 and miR-17 co-transfection but not for psiCHECK-CYP7A1 mutant.
Fengqiong Liu (717705), Ruijie Gong (5118944), Xiaofei Lv (409015)   +2 more
core   +1 more source

Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver[S]

Journal of Lipid Research, 2017
Osteopontin (OPN) is involved in different liver pathologies in which metabolic dysregulation is a hallmark. Here, we investigated whether OPN could alter liver, and more specifically hepatocyte, lipid metabolism and the mechanism involved. In mice, lack
Maitane Nuñez-Garcia, Beatriz Gomez-Santos, Xabier Buqué, Juan L. García-Rodriguez, Marta R. Romero, Jose J.G. Marin, Beatriz Arteta, Carmelo García-Monzón, Luis Castaño, Wing-kin Syn, Olatz Fresnedo, Patricia Aspichueta   +11 more
doaj   +1 more source

Structural characterization of human cholesterol 7α-hydroxylase

Journal of Lipid Research, 2014
Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol.
Wolfram Tempel, Irina Grabovec, Farrell MacKenzie, Yaroslav V. Dichenko, Sergey A. Usanov, Andrei A. Gilep, Hee-Won Park, Natallia Strushkevich   +7 more
doaj   +1 more source

The stimulatory effect of LXRα is blocked by SHP despite the presence of a LXRα binding site in the rabbit CYP7A1 promoter

Journal of Lipid Research, 2006
The transcription of the cholesterol 7α-hydroxylase gene (CYP7A1) is greatly decreased in cholesterol-fed rabbits. To determine whether the molecular structure of the promoter is responsible for this downregulation, we cloned the rabbit CYP7A1 promoter ...
Quan Shang, Luxing Pan, Monica Saumoy, John Y.L. Chiang, G. Stephen Tint, Gerald Salen, Guorong Xu   +6 more
doaj   +1 more source

Regulation of CYP7A1 and HMGCS1 protein level in the liver of Mig-6^d/d mice.

, 2012
Western blot analysis for CYP7A1 and HMGCS1 in the liver of Mig-6f/f and Mig-6d/d mice. Liver tissue from Mig-6f/f and Mig-6d/d mice were lysed, and equal amounts of protein were subjected to SDS-PAGE and Western blot analysis with anti-CYP7A1 and anti ...
Bon Jeong Ku (143640), Olga R. Ilkayeva (42420), Robert D. Stevens (42417), Lisa D. White (143647), Jae-Wook Jeong (143654), Jae Hee Lee (143643), Christopher B. Newgard (42425), Tae Hoon Kim (128536), Eric D. Buras (143645), Francesco J. DeMayo (143652), James R. Bain (42418)   +10 more
core   +1 more source