Results 61 to 70 of about 2,010 (126)

Taurine reduces cholesterol through CYP7A1 in a calcineurin-dependent manner

802-809Taurine (2-aminoethanesulfonic acid) could reduce serum and liver cholesterol concentrations via regulating expression and the activity of cholesterol 7α-hydroxylase (CYP7A1).
Gao, Ya, Zhang, Jing, Guo, Junxia, Zhao, Yuxing, Chen, Wen, Zhang, Yanzhen, Ou, Tong   +6 more
core   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

FXR-mediated down-regulation of CYP7A1 dominates LXRα in long-term cholesterol-fed NZW rabbits

Journal of Lipid Research, 2003
We investigated how cholesterol feeding regulates cholesterol 7α-hydroxylase (CYP7A1) via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor α (LXRα) in New Zealand white rabbits.
Guorong Xu, Hai Li, Lu-xing Pan, Quan Shang, Akira Honda, M. Ananthanarayanan, Sandra K. Erickson, Benjamin L. Shneider, Sarah Shefer, Jaya Bollineni, Barry M. Forman, Yasushi Matsuzaki, Frederick J. Suchy, G. Stephen Tint, Gerald Salen   +14 more
doaj   +1 more source

Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis

Hepatology Research, EarlyView.
Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa, Yoshiyuki Ueno, Hirokazu Takahashi, Ayumi Saito, Hideki Suganami, Atsushi Tanaka   +5 more
wiley   +1 more source

Developmental regulation of the gut–liver (FGF19-CYP7A1) axis in neonates

, 2018
Introduction: Fibroblast growth factor 19 (FGF19) is a gut-derived hormone that regulates the expression of CYP7A1, the rate-limiting enzyme in bile acid (BA) synthesis pathway.
Carayannopoulos, M. O., Hegyi, T., Aimee Herdt (5905760), Mary O. Carayannopoulos (5905766), Grace L. Guo (8255097), Lauren M. Aleksunes (8255094), Weinberger, B. I., Ian J. Griffin (5905754), Chris W. Lee (5905757), Guo, G. L., Memon, N., Barry I. Weinberger (5905763), Lee, C. W., Aleksunes, L. M., Naureen Memon (5905751), Griffin, I. J., Thomas Hegyi (1572), Herdt, A.   +17 more
core   +1 more source

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source

Methylation status on the promoter of CYP7A1, ABCA1, HMGCR, SREBP1 and SREBP2 genes in the liver of newly hatched chicks.

, 2015
A) Schematic diagram showing the promoter sequences of chicken CYP7A1, ABCA1, HMGCR, SREBP1 and SREBP2 genes CpG sites, determined in this study, on 5’-flanking promoter regions of CYP7A1 (-164~-51), ABCA1 (-25067~-24960), HMGCR (-849~-774), SREBP1 (-785~
Yun Hu (355918), Qinwei Sun (158590), Demin Cai (621171), Xi Li (19208), Ruqian Zhao (154843), Min Wang (21070), Xiaoliang Li (720274)   +6 more
core   +1 more source

Regulation of cholesterol-7α-hydroxylase: BAREly missing a SHP

Journal of Lipid Research, 2002
Cholesterol-7α-hydroxylase (CYP7A1) regulates the pathway through which cholesterol is converted into bile acids. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids
Roger A. Davis, Jon H. Miyake, To Yuen Hui, Nathanael J. Spann   +3 more
doaj   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

CYP7A1, BAAT and UGT1A1 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity

, 2016
SETTING: Evidence indicates that the polymorphisms in genes involved in bile acid metabolism may play an important role in the development of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in tuberculosis (TB) patients treated with anti ...
Xia, Y-Y., Chen, D-F., Zhan, S-Y., Tang, S-W., Wu, S-S., Chen, R., Wang, J., Lv, X-Z., Zhang, Y., Yang, Z-R.   +9 more
core   +1 more source