Results 1 to 10 of about 93,757 (114)

Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis [PDF]

JHEP Reports, 2022
Background & Aims: Farnesoid X receptor (FXR) agonists and fibroblast growth factor 19 (FGF19) analogues suppress bile acid synthesis and are being investigated for their potential therapeutic efficacy in cholestatic liver diseases.
Peder Rustøen Braadland, Kai Markus Schneider, Annika Bergquist, Antonio Molinaro, Anita Lövgren-Sandblom, Marcus Henricsson, Tom Hemming Karlsen, Mette Vesterhus, Christian Trautwein, Johannes Roksund Hov, Hanns-Ulrich Marschall   +10 more
doaj   +2 more sources

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle [PDF]

Animals, 2022
Myostatin (MSTN) is a major negative regulator of skeletal muscle mass and causes a variety of metabolic changes. However, the effect of MSTN knockout on bile acid metabolism has rarely been reported.
Di Wu, Mingjuan Gu, Zhuying Wei, Chunling Bai, Guanghua Su, Xuefei Liu, Yuefang Zhao, Lei Yang, Guangpeng Li   +8 more
doaj   +2 more sources

Inhibition of the Primary Bile Acid Synthesis Pathways in SD Rats at Different Altitudes [PDF]

Animals
Bile acids, the primary constituents of mammalian bile, are synthesized in the liver from cholesterol and secreted into the intestine to perform essential physiological functions.
Piao Ma, Qingfei Hu, Fan Ma, Wenjuan Zhang, Haifeng Gu, Dengbang Wei, Zhifang An   +6 more
doaj   +2 more sources

Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis

Liver Research, 2020
Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying ...
John Y.L. Chiang, Jessica M. Ferrell
doaj   +3 more sources

Dimethyl Sulfoxide Inhibits Bile Acid Synthesis in Healthy Mice but Does Not Protect Mice from Bile-Acid-Induced Liver Damage [PDF]

Biology, 2023
Bile acids serve a vital function in lipid digestion and absorption; however, their accumulation can precipitate liver damage. In our study, we probed the effects of dimethyl sulfoxide (DMSO) on bile acid synthesis and the ensuing liver damage in mice ...
Xi Chen, Huiqiao Li, Yu’e Liu, Jing Qi, Bingning Dong, Shixia Huang, Shangang Zhao, Yi Zhu   +7 more
doaj   +2 more sources

Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding

Journal of Lipid Research, 2001
Bile acids are synthesized via the classic pathway initiated by cholesterol 7α-hydroxylase (CYP7A1), and via alternate pathways, one of which is initiated by sterol 27-hydroxylase (CYP27).
Margrit Schwarz, David W. Russell, John M. Dietschy, Stephen D. Turley   +3 more
doaj   +3 more sources

The economy of the enterohepatic circulation of bile acids in the baboon. 2. Regulation of bile acid synthesis by enterohepatic circulation of bile acids.

Journal of Lipid Research, 1984
Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
doaj   +1 more source

Thyroid hormone differentially augments biliary sterol secretion in the rat. II. The chronic bile fistula model.

Journal of Lipid Research, 1992
To further define thyroid hormone effects on bile acid synthesis and biliary lipid secretion, studies were done in chronic bile fistula rats. Euthyroid and methimazole-hypothyroid rats, with and without triiodothyronine (T3) injection, had total bile ...
RL Gebhard, WF Prigge
doaj   +1 more source

Examination of bile acid negative feedback regulation in rats.

Journal of Lipid Research, 1988
Recent data obtained using cultured rat hepatocytes showed that bile acids do not inhibit bile acid synthesis, whereas cholesterol concentrations vary in parallel with bile acid synthesis (Davis et al. (1983. J. Biol. Chem. 258: 4079-4082).
R A Davis, C A Musso, M Malone-McNeal, G R Lattier, P M Hyde, J Archambault-Schexnayder, M Straka   +6 more
doaj   +1 more source

Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits

Journal of Lipid Research, 2000
We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu, Benjamin L. Shneider, Sarah Shefer, Lien B. Nguyen, Ashok K. Batta, G. Stephen Tint, Marco Arrese, Sundararajah Thevananther, Lin Ma, Siegfried Stengelin, Werner Kramer, David Greenblatt, Mark Pcolinsky, Gerald Salen   +13 more
doaj   +1 more source