Results 1 to 10 of about 87,571 (149)
Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis [PDF]
Liver Research, 2020 Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying ...
John Y.L. Chiang, Jessica M. Ferrell
doaj +4 more sources
Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis [PDF]
JHEP Reports, 2022 Background & Aims: Farnesoid X receptor (FXR) agonists and fibroblast growth factor 19 (FGF19) analogues suppress bile acid synthesis and are being investigated for their potential therapeutic efficacy in cholestatic liver diseases.
Peder Rustøen Braadland +10 more
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Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle [PDF]
Animals, 2022 Myostatin (MSTN) is a major negative regulator of skeletal muscle mass and causes a variety of metabolic changes. However, the effect of MSTN knockout on bile acid metabolism has rarely been reported.
Di Wu +8 more
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Inhibition of the Primary Bile Acid Synthesis Pathways in SD Rats at Different Altitudes [PDF]
AnimalsBile acids, the primary constituents of mammalian bile, are synthesized in the liver from cholesterol and secreted into the intestine to perform essential physiological functions.
Piao Ma +6 more
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Dimethyl Sulfoxide Inhibits Bile Acid Synthesis in Healthy Mice but Does Not Protect Mice from Bile-Acid-Induced Liver Damage [PDF]
Biology, 2023 Bile acids serve a vital function in lipid digestion and absorption; however, their accumulation can precipitate liver damage. In our study, we probed the effects of dimethyl sulfoxide (DMSO) on bile acid synthesis and the ensuing liver damage in mice ...
Xi Chen +7 more
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Bile acids: regulation of synthesis [PDF]
Journal of Lipid Research, 2009 Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors
John Y.L. Chiang
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Bile Acid Synthesis Defect and Hyperinsulinism. [PDF]
ACG Case Rep J, 2018 Congenital defects of bile acid synthesis are rare disorders that cause progressive liver dysfunction. Prolonged neonatal hyperinsulism (PNH) is a separate entity that leads to persistent hypoglycemia secondary to stress. We present a 4-month-old infant who presented with liver failure secondary to a bile acid synthesis defect.
Rogers M, Sylvester F, Lichtman S.
europepmc +3 more sources
Journal of Lipid Research, 2001 Bile acids are synthesized via the classic pathway initiated by cholesterol 7α-hydroxylase (CYP7A1), and via alternate pathways, one of which is initiated by sterol 27-hydroxylase (CYP27).
Margrit Schwarz +3 more
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Effectiveness and Safety of Personalized Cholic Acid Treatment in Patients With Bile Acid Synthesis Defects. [PDF]
J Inherit Metab DisPolak Y +8 more
europepmc +2 more sources
Journal of Lipid Research, 1984 Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
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