∆4-3-oxo-5β-reductase deficiency: favorable outcome in 16 patients treated with cholic acid [PDF]
Orphanet Journal of Rare Diseases, 2023 Background Oral cholic acid therapy is an effective therapy in children with primary bile acid synthesis deficiencies. Most reported patients with this treatment have 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency.
Antoine Gardin +21 more
doaj +2 more sources
Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp. [PDF]
Marine Drugs, 2022 Bacterial symbionts of marine invertebrates are rich sources of novel, pharmaceutically relevant natural products that could become leads in combatting multidrug-resistant pathogens and treating disease.
Fazlin Pheiffer +9 more
doaj +2 more sources
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Cholic Acid (MT921) after a Subcutaneous Injection in the Submental Area to Humans [PDF]
Pharmaceuticals, 2021 This study aimed to explore pharmacokinetics, pharmacodynamics, and safety/tolerability of MT921, an injectable cholic acid, after a single subcutaneous administration to healthy volunteers.
Hyewon Chung +6 more
doaj +2 more sources
Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics [PDF]
Pharmacology Research & PerspectivesHuman cytochrome P450 3A4 (CYP3A4) is a drug‐metabolizing enzyme that is abundantly expressed in the liver and intestine. It is an important issue whether compounds of interest affect the expression of CYP3A4 because more than 30% of commercially ...
Genki Minegishi +5 more
doaj +2 more sources
Gut microbiota-derived cholic acid mediates neonatal brain immaturity and white matter injury under chronic hypoxia [PDF]
iScienceSummary: Chronic hypoxia, common in neonates, disrupts gut microbiota balance, which is crucial for brain development. This study utilized cyanotic congenital heart disease (CCHD) patients and a neonatal hypoxic rat model to explore the association. Both
Yichen Yan +13 more
doaj +2 more sources
Cholic acid increases plasma cholesterol in Smith-Lemli-Opitz syndrome: A pilot study [PDF]
Molecular Genetics and Metabolism ReportsBackground: Smith-Lemli-Opitz syndrome (SLOS) is an inherited disorder of cholesterol biosynthesis associated with congenital malformations, growth delay, intellectual disability and behavior problems.
Ellen R. Elias +5 more
doaj +2 more sources
Nanobiosensor Design to Detect Cholic Acid Using Multiwalled Carbon Nanotube /TiO2 Nanoparticle for 3α-Hydroxysteroid Dehydrogenase Immobilization [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 Determination of cholic acid concentration is a useful method to monitor liver diseases. We propose a rapid and simple method for measuring cholic acid.
Emad Mohammad Jassim +4 more
doaj +1 more source
The effect of cholic acid treatment on the oxidative status of soybean plants [PDF]
Journal of the Serbian Chemical Society, 2009 The objective of this work was to study the effect of treatment of young soybean plants with cholic acid of different concentrations on their oxidative status.
SLAVKO E. KEVREŠAN +4 more
doaj +3 more sources
UPLC-QqQ-MS/MS-based Quantitative Analysis on Bile Acid in Hyperthyroidism Rats to Explore the Effects of Ginseng Herbs [PDF]
Zhipu Xuebao, 2023 A method of ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS) was developed to determine the contents of deoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, cholic acid, glycinecholic acid ...
LIU Lin-lin, JIN Mo-zhu, DOU De-qiang
doaj +1 more source
Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy
Hepatology, EarlyView., 2022 Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat +22 more
wiley +1 more source