Results 1 to 10 of about 14,871 (183)

Investigation of the mechanism of chenodeoxycholic acid in treating acute lung injury through network pharmacology and experimental validation [PDF]

Scientific Reports
Network pharmacology and molecular simulation techniques were employed to predict the potential targets and signaling pathways of chenodeoxycholic acid in the treatment of acute lung injury. Subsequently, its therapeutic effects on acute lung injury were
Chong He, Mengmeng Jiang, Qian Xiong, Zuoxi Huang   +3 more
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Microwave synthesis of novel chenodeoxycholic acid esters and comparative study of chromatographic behavior and lipophilicity

Macedonian Journal of Chemistry and Chemical Engineering, 2023
In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The
Ksenija Pavlović, Ljubica Grbović, Milica Karadžić Banjac, Strahinja Kovačević, Anamarija Mandić, Sanja Podunavac-Kuzmanović, Bojana Vasiljević   +6 more
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Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate.

Journal of Lipid Research, 1983
The formation of ursodeoxycholic acid from chenodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in vitro in fecal incubations as well as in vivo in the human colon.
H Fromm, R P Sarva, F Bazzoli
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Metabolism of potential precursors of chenodeoxycholic acid in cerebrotendinous xanthomatosis (CTX).

Journal of Lipid Research, 1979
In patients with cerebrotendinous xanthomatosis (CTX), diminished cholic acid production is associated with incomplete oxidation of the cholesterol side chain and the excretion of C(25)-hydroxy bile alcohols.
G Salen, S Shefer, E H Mosbach, S Hauser, B I Cohen, G Nicolau   +5 more
doaj   +1 more source

Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota

Biomolecules, 2022
Gut microbes have been recognized to convert human bile acids by deconjugation, dehydroxylation, dehydrogenation, and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has been ...
Carlos J. Garcia, Vit Kosek, David Beltrán, Francisco A. Tomás-Barberán, Jana Hajslova   +4 more
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Metabolism of 7 beta-alkyl chenodeoxycholic acid analogs and their effect on cholesterol metabolism in hamsters.

Journal of Lipid Research, 1990
The metabolism of 7-ethyl- and 7-propyl-chenodeoxycholic acids was studied in hamsters. Both bile acid analogs were absorbed efficiently by the intestine and secreted into the bile at rates similar to those of chenodeoxycholic acid.
M Une, K Yamanaga, EH Mosbach, K Tsujimura, T Hoshita   +4 more
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Purification of Hyodeoxycholic Acid and Chenodeoxycholic Acid from Pig Bile Saponification Solution Using Column Chromatography [PDF]

Chemical and Biochemical Engineering Quarterly
The purpose of this study was to purify hyodeoxycholic acid and chenodeoxycholic acid from pig bile saponification solution using column chromatography. The optimal resin was selected through static adsorption experiments.
B. Liu, T. Chen, X. Chen, X. Li, K. Abudureheman, S. Hu, X. Gong   +6 more
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Suitability of [11,12-3H2]chenodeoxycholic acid and [11,12-3H2]lithocholic acid for isotope dilution studies of bile acid metabolism in man

Journal of Lipid Research, 1977
Studies were carried out to assess the stability of the label in [11,12-3H2]chenodeoxycholic acid and [11,12-3H2]lithocholic acid during enterohepatic cycling and thus define the suitability of these tracers for isotope dilution studies of bile acids in ...
P Y Ng, R N Allan, A F Hofmann
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7alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum.

Journal of Lipid Research, 1979
The rate of 7alpha-dehydroxylation of primary bile acids was quantitatively measured radiochromatographically in anaerobically washed whole cell suspensions of Clostridium leptum.
E J Stellwag, P B Hylemon
doaj   +1 more source

An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man

Journal of Lipid Research, 1980
The present study was designed to obtain more definitive information in man on the metabolic pathways to chenodeoxycholic acid and to cholic acid via a pathway not involving an initial 7 alpha-hydroxylation of cholesterol. Four bile fistula patients were
L Swell, J Gustafsson, C C Schwartz, L G Halloran, H Danielsson, Z R Vlahcevic   +5 more
doaj   +1 more source