Results 1 to 10 of about 21,006 (223)

Investigation of the mechanism of chenodeoxycholic acid in treating acute lung injury through network pharmacology and experimental validation [PDF]

Scientific Reports
Network pharmacology and molecular simulation techniques were employed to predict the potential targets and signaling pathways of chenodeoxycholic acid in the treatment of acute lung injury. Subsequently, its therapeutic effects on acute lung injury were
Chong He, Mengmeng Jiang, Qian Xiong, Zuoxi Huang   +3 more
doaj   +2 more sources

Microwave synthesis of novel chenodeoxycholic acid esters and comparative study of chromatographic behavior and lipophilicity

Macedonian Journal of Chemistry and Chemical Engineering, 2023
In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The
Ksenija Pavlović, Ljubica Grbović, Milica Karadžić Banjac, Strahinja Kovačević, Anamarija Mandić, Sanja Podunavac-Kuzmanović, Bojana Vasiljević   +6 more
doaj   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate.

Journal of Lipid Research, 1983
The formation of ursodeoxycholic acid from chenodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in vitro in fecal incubations as well as in vivo in the human colon.
H Fromm, R P Sarva, F Bazzoli
doaj   +1 more source

Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota

Biomolecules, 2022
Gut microbes have been recognized to convert human bile acids by deconjugation, dehydroxylation, dehydrogenation, and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has been ...
Carlos J. Garcia, Vit Kosek, David Beltrán, Francisco A. Tomás-Barberán, Jana Hajslova   +4 more
doaj   +1 more source

Mutations in SRD5B1 (AKR1D1), the gene encoding δ 4-3-oxosteroid 5β-reductase, in hepatitis and liver failure in infancy [PDF]

, 2003
Background: A substantial group of patients with cholestatic liver disease in infancy excrete, as the major urinary bile acids, the glycine and taurine conjugates of 7α-hydroxy-3-oxo-4-cholenoic acid and 7α,12α -dihydroxy-3-oxo-4-cholenoic acid.
Bouquet, J. (Jan), Clayton, P. (Peter), Custard, E.J. (E.), Duran, M. (Marinus), Lemonde, H. (Hugh), Overmars, W., Scambler, P.J. (Peter)   +6 more
core   +5 more sources

Metabolism of potential precursors of chenodeoxycholic acid in cerebrotendinous xanthomatosis (CTX).

Journal of Lipid Research, 1979
In patients with cerebrotendinous xanthomatosis (CTX), diminished cholic acid production is associated with incomplete oxidation of the cholesterol side chain and the excretion of C(25)-hydroxy bile alcohols.
G Salen, S Shefer, E H Mosbach, S Hauser, B I Cohen, G Nicolau   +5 more
doaj   +1 more source

Experimental isovalthinuria. III. Induction by bile acids, and hypocholesterolemic agents [PDF]

, 1963
Some bile acids (dehydrocholic, cholic, chenodeoxycholic, ursodeoxycholic, and deoxycholic acids), and some hypocholesterolemic agents (22, 25 diazacholestanol, 20,25-diazacholesterol, triparanol, and SKF 525-A) are the inducers of isovalthinuria in ...
Ubuka, Toshihiko
core   +1 more source

Metabolism of 7 beta-alkyl chenodeoxycholic acid analogs and their effect on cholesterol metabolism in hamsters.

Journal of Lipid Research, 1990
The metabolism of 7-ethyl- and 7-propyl-chenodeoxycholic acids was studied in hamsters. Both bile acid analogs were absorbed efficiently by the intestine and secreted into the bile at rates similar to those of chenodeoxycholic acid.
M Une, K Yamanaga, EH Mosbach, K Tsujimura, T Hoshita   +4 more
doaj   +1 more source

Test of different sensitizing dyes in dye-sensitized solar cells based on Nb2O5 photoanodes [PDF]

, 2018
High-performance dyes routinely employed in TiO2-based dye-sensitized solar cells (DSSCs) were tested in cells assembled using Nb2O5 nanostructure-based photoanodes. The sensitizers were chosen among both metal-complex (two Ru-based, N749 and C106, and
Latini, Alessandro, Panetta, Riccardo
core   +1 more source