Results 11 to 20 of about 14,871 (183)

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Ursodeoxycholic acid, chenodeoxycholic acid, and 7-ketolithocholic acid are primary bile acids of the guinea pig.

Journal of Lipid Research, 1990
Guinea pig gallbladder bile contains chenodeoxycholic acid (62 +/- 5%), ursodeoxycholic acid (8 +/- 5%), and 7-ketolithocholic acid (30 +/- 5%). All three bile acids became labeled to the same specific activity within 30 min after [3H]cholesterol was ...
GS Tint, GR Xu, AK Batta, S Shefer, W Niemann, G Salen   +5 more
doaj   +1 more source

Sex differences in gallbladder bile acid composition and hepatic steroid 12 alpha-hydroxylase activity in hamsters.

Journal of Lipid Research, 1983
The gallbladder bile acid composition and the activity of the hepatic steroid 12 alpha-hydroxylase were determined in male and female hamsters. Cholic acid, chenodeoxycholic acid, and deoxycholic acid were the major bile acids in both sexes; in addition,
S Kuroki, S Muramoto, T Kuramoto, T Hoshita   +3 more
doaj   +1 more source

Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lecithinase-lipase-negative Clostridia.

Journal of Lipid Research, 1981
Six strains of lecithinase-lipase-negative Clostridia, isolated from human feces, were capable of oxidizing chenodeoxycholic acid to 3 alpha-hydroxy-7 keto-5 beta-cholanoic acid and of epimerizing it to ursodeoxycholic acid.
R Edenharder, T Knaflic
doaj   +1 more source

Synthesis of 11, 12-2H2- and 11, 12-3H2-labeled chenodeoxycholic and lithocholic acids

Journal of Lipid Research, 1976
Deuterium- and tritium-labeled chenodeoxycholic acid and lithocholic were prepared by catalytic reduction of their respective Δ11 derivatives. Structures of the intermediates and their isotopic purity were verified by chemical ionization and electron ...
A E Cowen, A F Hofmann, D L Hachey, P J Thomas, D T Belobaba, P D Klein, L Tökes   +6 more
doaj   +1 more source

pH-Solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena.

Journal of Lipid Research, 1980
We examined by titration the electrochemical properties, apparent pK (pK'a), precipitation pH, and undissociated bile acid solubilities of chenodeoxycholic acid and its 7 beta epimer, ursodeoxycholic acid and their glycine conjugates as functions of a ...
H Igimi, M C Carey
doaj   +1 more source

Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and biliary lipid composition in man: relation to cholesterol gallstone disease and effects of cholic acid and chenodeoxycholic acid treatment

Journal of Lipid Research, 1981
The present work was undertaken in order to study whether or not there is a relation between hepatic HMG CoA reductase, hepatic cholesterol concentration, and biliary lipid composition.
J Ahlberg, B Angelin, K Einarsson
doaj   +1 more source

The economy of the enterohepatic circulation of bile acids in the baboon. 2. Regulation of bile acid synthesis by enterohepatic circulation of bile acids.

Journal of Lipid Research, 1984
Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
doaj   +1 more source

Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients

Journal of Lipid Research, 1973
7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish
Russell F. Hanson, Peter D. Klein, Gale C. Williams   +2 more
doaj   +1 more source

Bile acid synthesis in HepG2 cells: effect of cyclosporin

Journal of Lipid Research, 1994
The hypothesis that cyclosporin specifically affects the pathway of bile acid synthesis that begins with 27-hydroxylation of cholesterol was evaluated in HepG2 cells, which synthesize chenodeoxycholic acid and cholic acid from endogenous 7 alpha ...
J Levy, K Budai, N B Javitt
doaj   +1 more source