Results 21 to 30 of about 2,533,937 (176)
Journal of Traditional Chinese Medical Sciences, 2023 Objective: To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine (TCM) based on the regulation of gene expression. Methods: Genome-wide gene expression profiles of Michigan Cancer Foundation-7 (
Yongchun Huang +5 more
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7alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum.
Journal of Lipid Research, 1979 The rate of 7alpha-dehydroxylation of primary bile acids was quantitatively measured radiochromatographically in anaerobically washed whole cell suspensions of Clostridium leptum.
E J Stellwag, P B Hylemon
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Screening the binding affinity of bile acid derivatives for the glucocorticoid receptor ligand-binding domain [PDF]
Journal of the Serbian Chemical Society, 2023 The necessity of anti-inflammatory drugs such as glucocorticoids has been evident during the COVID-19 pandemic. Glucocorticoids, are the standard therapy for the treatment of moderate and severe COVID-19 patients.
Bjedov Srđan +7 more
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Journal of Lipid Research, 1979 Side chain oxidation and cleavage of precursors in cholic acid synthesis is thought to involve initial hydroxylation at either position 25 or 26 of the side chain. Therefore, the conversion of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 26-tetrol and 5
R F Hanson, A B Staples, G C Williams
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Journal of Lipid Research, 1981 A new method is described for measuring the cholic acid turnover and pool size by a single duodenal intubation technique. The method is based on determination in a single bile sample of the ratio of the specific activities of [14C]cholic acid and [3H ...
G Vantrappen, P Rutgeerts, Y Ghoos
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Journal of Lipid Research, 1976 An enzyme assay was developed to measure the conversion of the bile acid precursor, 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid (THCA), into cholic acid using homogenates of human liver biopsies.
R F Hanson, H L Sharp, G C Williams
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Facially Amphiphilic Cholic Acid-Lysine Conjugates as Promising Antimicrobials. [PDF]
ACS Omega, 2020 The emergence of multidrug-resistant microbes is a significant health concern posing a constant need for new antimicrobials. Membrane-targeting antibiotics are promising candidates with reduced ability of microbes to develop resistance.
Singla P +6 more
europepmc +2 more sources
Journal of Lipid Research, 1983 The possibility that the 12 alpha-hydroxylase involved in formation of bile acids is of regulatory importance for the ratio between cholic acid and chenodeoxycholic acid in bile was studied with an in vivo technique.
I Björkhem, M Eriksson, K Einarsson
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Anionic Facial Amphiphiles from Cholic Acid
, 2016 Anionic facial amphiphiles have been prepared from cholic acid. These compounds offer antipodes of recently reported cationic amphiphiles derived from cholic acid.
David B. McMullin (3063027) +4 more
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Journal of Lipid Research, 1986 The extent of oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in bile acids during the enterohepatic circulation in man was studied with the use of [3 beta-3H]-labeled deoxycholic acid and cholic acid, [7 beta-3H]-labeled cholic ...
I Björkhem +3 more
doaj +1 more source