Results 21 to 30 of about 87,670 (247)

Studies of bile acid secretion by isolated rat hepatocytes.

Journal of Lipid Research, 1978
Bile acid secretion was studied in isolated rat hepatocytes cultured in medium supplemented with cofactors and succinate. Succinate as a respiratory substrate was found to be essential for bile acid synthesis.
B Gardner, M S Chenouda
doaj   +1 more source

Effects of fasting on bile acid metabolism and biliary lipid composition in man

Journal of Lipid Research, 1976
The effects of a four to six day fast on gallbladder bile lipid composition, bile acid pool size, bile acid composition, and cholic acid metabolism have been determined in normal human subjects.
W C Duane, R L Ginsberg, L J Bennion
doaj   +1 more source

Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion

Journal of Lipid Research, 1998
The effect of cholesterol feeding (3 g/day) on bile acid synthesis was examined in 10 New Zealand white rabbits (NZW), 8 Watanabe heterozygous and 10 homozygous rabbits with partial and complete deficiencies of LDL receptors. After 10 days of cholesterol
Guorong Xu, Gerald Salen, Sarah Shefer, G. Stephen Tint, Lien B. Nguyen, Thomas T. Parker, Thomas S. Chen, Jeremy Roberts, Xianglin Kong, David Greenblatt   +9 more
doaj   +1 more source

Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease

Biology Direct, 2023
The response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated that upregulation of the alternative bile acid synthesis pathway increases the OCA treatment response ...
Seung Min Lee, Dae Won Jun, Eileen Laurel Yoon, Ju Hee Oh, Yoon Jin Roh, Eun Jeoung Lee, Ji-Hee Shin, Young-Do Nam, Hyun Sung Kim   +8 more
doaj   +1 more source

Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism

Lipids in Health and Disease, 2018
Background Recently, trimethylamine-N-oxide (TMAO) plasma levels have been proved to be associated with atherosclerosis development. Among the targets aimed to ameliorating atherosclerotic lesions, inducing bile acid synthesis to eliminate excess ...
Lin Ding, Mengru Chang, Ying Guo, Lingyu Zhang, Changhu Xue, Teruyoshi Yanagita, Tiantian Zhang, Yuming Wang   +7 more
doaj   +1 more source

Regulation of Bile Acid and Cholesterol Metabolism by PPARs

PPAR Research, 2009
Bile acids are amphipathic molecules synthesized from cholesterol in the liver. Bile acid synthesis is a major pathway for hepatic cholesterol catabolism.
Tiangang Li, John Y. L. Chiang
doaj   +1 more source

Biliary lipid secretion in hypercholesterolemia.

Journal of Lipid Research, 1979
A report on the effects of primary bile acid ingestion alone or in combination with plant sterols on serum cholesterol levels, biliary lipid secretion, and bile acid metabolism.
T N Tangedahl, A F Hofmann, B A Kottke
doaj   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases

Frontiers in Medicine, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Vik Meadows, Vik Meadows, Lindsey Kennedy, Debjyoti Kundu, Gianfranco Alpini, Gianfranco Alpini, Heather Francis, Heather Francis   +7 more
doaj   +1 more source

Measurement of bile acid synthesis by three different methods in hypertriglyceridemic and control subjects.

Journal of Lipid Research, 1997
In hypertriglyceridemic subjects, bile acid synthesis measured by isotope dilution is consistently higher than synthesis measured by fecal acidic sterol output.
W C Duane
doaj   +1 more source

Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat.

Journal of Lipid Research, 1989
Hepatic bile acid synthesis is thought to be under negative feedback control by bile salts in the enterohepatic circulation, acting at the level of cholesterol 7 alpha-hydroxylase (C7 alpha H), the initial and rate-limiting step in the bile acid ...
D M Heuman, P B Hylemon, Z R Vlahcevic
doaj   +1 more source