Results 11 to 20 of about 87,670 (247)
Journal of Lipid Research, 1992 To further define thyroid hormone effects on bile acid synthesis and biliary lipid secretion, studies were done in chronic bile fistula rats. Euthyroid and methimazole-hypothyroid rats, with and without triiodothyronine (T3) injection, had total bile ...
RL Gebhard, WF Prigge
doaj +1 more source
Examination of bile acid negative feedback regulation in rats.
Journal of Lipid Research, 1988 Recent data obtained using cultured rat hepatocytes showed that bile acids do not inhibit bile acid synthesis, whereas cholesterol concentrations vary in parallel with bile acid synthesis (Davis et al. (1983. J. Biol. Chem. 258: 4079-4082).
R A Davis +6 more
doaj +1 more source
Journal of Lipid Research, 2000 We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu +13 more
doaj +1 more source
Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in MiceSummary
Cellular and Molecular Gastroenterology and Hepatology, 2017 Background & Aims: Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is unknown.
Anne S. Henkel +3 more
doaj +1 more source
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption
Journal of Lipid Research, 2007 Bile acid malabsorption, which in patients leads to excessive fecal bile acid excretion and diarrhea, is characterized by a vicious cycle in which the feedback regulation of bile acid synthesis is interrupted, resulting in additional bile acid production.
Diana Jung +6 more
doaj +1 more source
Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2016 Alterations in bile acid (BA) synthesis and transport have the potential to affect multiple metabolic pathways in the pathophysiology of obesity.The objective of the study was to investigate the effects of obesity on serum fluctuations of BAs and markers of BA synthesis.We measured BA fluctuations in 11 nonobese and 32 obese subjects and BA transporter
Haeusler, Rebecca A +8 more
openaire +2 more sources
Contraceptive steroids alter the steady-state kinetics of bile acids.
Journal of Lipid Research, 1988 Contraceptive steroids increase the ratio of cholic acid to chenodeoxycholic acid in bile. This alteration may contribute to the development of cholesterol gallstones.
G T Everson, P Fennessey, F Kern, Jr
doaj +1 more source
Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver.
Journal of Lipid Research, 1992 Hepatic free cholesterol levels are influenced by cholesterol synthesis and ester formation, which, in turn, might regulate cholesterol secretion into bile and plasma.
BG Stone, CD Evans
doaj +1 more source
Journal of Lipid Research, 1987 Cultured rat hepatocytes obtained by liver perfusion with collagenase in the presence of soybean trypsin inhibitor were used to examine the role of high density lipoproteins (HDL) in supplying cholesterol to the hepatocyte for bile acid synthesis. Within
A M Mackinnon +3 more
doaj +1 more source
The Effect of Bile Acid Synthesis on Cholesterol Secretion into the Bile
Annals of Surgery, 1975 Cholesterol secretion into the bile has been shown to be related to the bile acid secretion rate. It has been suggested that the availability of bile acid micelles controls the entry of cholesterol into the bile. However, previous data could have been interpreted to indicate that bile acid synthesis controls cholesterol secretion into the bile.
S M, Strasberg, R G, Ilson
openaire +3 more sources