Results 11 to 20 of about 4,927,968 (256)

Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]

, 2004
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Thiessen, K., Parhofer, K. G., Fischer, S., Sauter, G. H., Jungst, D., Jungst, C.   +5 more
core   +1 more source

Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is unknown.
Anne S. Henkel, Brian LeCuyer, Shantel Olivares, Richard M. Green   +3 more
doaj   +1 more source

FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption

Journal of Lipid Research, 2007
Bile acid malabsorption, which in patients leads to excessive fecal bile acid excretion and diarrhea, is characterized by a vicious cycle in which the feedback regulation of bile acid synthesis is interrupted, resulting in additional bile acid production.
Diana Jung, Takeshi Inagaki, Robert D. Gerard, Paul A. Dawson, Steven A. Kliewer, David J. Mangelsdorf, Antonio Moschetta   +6 more
doaj   +1 more source

New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]

, 2013
This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
core   +1 more source

Contraceptive steroids alter the steady-state kinetics of bile acids.

Journal of Lipid Research, 1988
Contraceptive steroids increase the ratio of cholic acid to chenodeoxycholic acid in bile. This alteration may contribute to the development of cholesterol gallstones.
G T Everson, P Fennessey, F Kern, Jr
doaj   +1 more source

Mutations in SRD5B1 (AKR1D1), the gene encoding Delta(4)-3-oxosteroid 5 beta-reductase, in hepatitis and liver failure in infancy [PDF]

, 2003
Background: A substantial group of patients with cholestatic liver disease in infancy excrete, as the major urinary bile acids, the glycine and taurine conjugates of 7alpha-hydroxy-3-oxo-4-cholenoic acid and 7alpha, 12alpha-dihydroxy-3- oxo-4-cholenoic ...
Duran, M., Scambler, PJ, Custard, E. J., Bouquet, J, Lemonde, H. A., Clayton, P. T., Duran, M, Overmars, H, Bouquet, J., Scambler, P.J., Lemonde, H., Clayton, P.T., Custard, EJ, Scambler, P. J., Clayton, PT, Lemonde, HA, Custard, E.J., Overmars, H.   +17 more
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Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver.

Journal of Lipid Research, 1992
Hepatic free cholesterol levels are influenced by cholesterol synthesis and ester formation, which, in turn, might regulate cholesterol secretion into bile and plasma.
BG Stone, CD Evans
doaj   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen, Hageman, Jurre, Herrema, H.J., Folkert Kuipers, Hageman, J., Kuipers, Folkert, Herrema, Hilde, Hilde Herrema, Kuipers, Folkert; id_orcid, Groen, A.K., Kuipers, F., Groen, Albert K., Jurre Hageman   +12 more
core   +1 more source

Regulation of bile acid synthesis in cultured rat hepatocytes: stimulation by apoE-rich high density lipoproteins.

Journal of Lipid Research, 1987
Cultured rat hepatocytes obtained by liver perfusion with collagenase in the presence of soybean trypsin inhibitor were used to examine the role of high density lipoproteins (HDL) in supplying cholesterol to the hepatocyte for bile acid synthesis. Within
A M Mackinnon, C A Drevon, T M Sand, R A Davis   +3 more
doaj   +1 more source

The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]

, 2013
Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
core   +1 more source