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Endometriosis and nuclear receptors [PDF]
Human Reproduction Update, 2019 Abstract BACKGROUND Endometriosis is recognized as a steroid-dependent disorder; however, the precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling pathways are not well understood. OBJECTIVE AND RATIONALE
Bahar D Yilmaz +2 more
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The Mediator Complex: A Regulatory Hub for Transcriptional Activity of Nuclear Receptors [PDF]
CellsThe Mediator complex plays a key role in gene transcription. In particular, the interaction of the Mediator complex with nuclear receptors, the known transcription factors, regulates multiple nuclear receptor-mediated gene transcription pathways and ...
Liming Zhou +3 more
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Nuclear receptors as novel regulators that modulate cancer radiosensitivity and normal tissue radiotoxicity [PDF]
Molecular CancerNuclear receptors (NRs) are a superfamily of transcription factors that are involved in various pathophysiological processes. The human genome contains 48 types of nuclear receptors, including steroid hormone receptors (e.g., estrogen receptor [ER] and ...
Xiaochen Meng +3 more
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Nuclear receptors in neurodegenerative diseases
Neurobiology of Disease, 2014 Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders.
Rebecca Skerrett +2 more
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Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions [PDF]
Signal Transduction and Targeted TherapyNuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands, including steroid hormones, thyroid hormone, vitamin D ...
Ping Jin +8 more
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Viruses, 2021 Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in HPV-
Seoung-Ae Lee +4 more
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Biomolecules, 2023 Liver X receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors which regulate the expression of lipid and cholesterol metabolism genes.
Asitha Premaratne +5 more
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Current strategies in engaging oncolytic viruses with antitumor immunity
Molecular Therapy: Oncolytics, 2021 Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni +2 more
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Liver X Receptor Regulation of Glial Cell Functions in the CNS
Biomedicines, 2022 In this review, we discuss the role of liver X receptors (LXRs) in glial cells (microglia, oligodendrocytes and astrocytes) in the central nervous system (CNS).
Xiaoyu Song +3 more
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British Journal of Pharmacology, 2007 ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
S. P. H. Alexander +2 more
openaire +3 more sources