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Nuclear receptors in neurodegenerative diseases
Neurobiology of Disease, 2014 Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders.
Gary Landreth, Tarja Malm
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Endometriosis and nuclear receptors. [PDF]
Human Reproduction Update, 2019 BACKGROUND Endometriosis is recognized as a steroid-dependent disorder; however, the precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling pathways are not well understood.
B. Yilmaz, S. Bulun
semanticscholar +3 more sources
Oxysterols and nuclear receptors.
Molecular and Cellular Endocrinology, 2019 Oxysterols are derivatives of cholesterol and an important regulator of cholesterol metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X receptors.
Liqian Ma, Erik R. Nelson
semanticscholar +3 more sources
Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors
Nature Reviews Molecular Cell Biology, 2016 Steroid hormone receptors mediate numerous crucial biological processes and are classically thought to function as transcriptional regulators in the nucleus.
Stephen Hammes, Ellis Levin
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PLoS ONE, 2015 Bisphenol A (BPA) can interact with nuclear receptors and affect the normal function of nuclear receptors in very low doses, which causes BPA to be one of the most controversial endocrine disruptors.
Lanlan Li +5 more
doaj +2 more sources
REV-ERB and ROR nuclear receptors as drug targets
Nature Reviews Drug Discovery, 2014 The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including regulation of metabolism ...
Douglas Kojetin, Thomas Burris
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The Mediator Complex: A Regulatory Hub for Transcriptional Activity of Nuclear Receptors [PDF]
CellsThe Mediator complex plays a key role in gene transcription. In particular, the interaction of the Mediator complex with nuclear receptors, the known transcription factors, regulates multiple nuclear receptor-mediated gene transcription pathways and ...
Liming Zhou +3 more
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Nuclear receptors as novel regulators that modulate cancer radiosensitivity and normal tissue radiotoxicity [PDF]
Molecular CancerNuclear receptors (NRs) are a superfamily of transcription factors that are involved in various pathophysiological processes. The human genome contains 48 types of nuclear receptors, including steroid hormone receptors (e.g., estrogen receptor [ER] and ...
Xiaochen Meng +3 more
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Nuclear receptors in bile acid metabolism
Drug Metabolism Reviews, 2013 Bile acids are signaling molecules that activate nuclear receptors, such as farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, and vitamin D receptor, and play a critical role in the regulation of lipid, glucose, energy, and ...
Tiangang Li, John Chiang
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Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions [PDF]
Signal Transduction and Targeted TherapyNuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands, including steroid hormones, thyroid hormone, vitamin D ...
Ping Jin +8 more
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