Results 41 to 50 of about 548,108 (301)

Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patterns

BMC Evolutionary Biology, 2009
Background Nuclear receptors are a superfamily of metazoan transcription factors that regulate diverse developmental and physiological processes.
Tarrant Ann M, Reitzel Adam M
doaj   +1 more source

Individual Epitope-Specific CD8⁺ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection

Pathogens, 2023
A hallmark in chronic viral infections are exhausted antigen-specific CD8+ T cell responses and the inability of the immune system to eliminate the virus.
Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R. M. Kraft   +6 more
doaj   +1 more source

Nuclear receptor corepressors [PDF]

Nuclear Receptor Signaling, 2003
The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins.
openaire   +2 more sources

Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol

Frontiers in Endocrinology, 2018
27-hydroxycholesterol (27HC) is an abundant cholesterol metabolite in human circulation and promotes breast cancer cell proliferation. Although lung is one of the organs that contain high levels of 27HC, the role of 27HC in lung is unknown. In this study,
Shiro Hiramitsu, Shiro Hiramitsu, Tomonori Ishikawa, Wan-Ru Lee, Tamor Khan, Tamor Khan, Christine Crumbley, Christine Crumbley, Nimra Khwaja, Nimra Khwaja, Faezeh Zamanian, Faezeh Zamanian, Arvand Asghari, Arvand Asghari, Mehmet Sen, Yang Zhang, John R. Hawse, John D. Minna, Michihisa Umetani, Michihisa Umetani   +19 more
doaj   +1 more source

Nuclear Receptors and the Hidden Language of the Metabolome. [PDF]

Cells
Nuclear hormone receptors (NHRs) are a family of ligand-regulated transcription factors that control key aspects of development and physiology. The regulation of NHRs by ligands derived from metabolism or diet makes them excellent pharmacological targets,
Chen Y, Anderson MT, Payne N, Santori FR, Ivanova NB.   +4 more
europepmc   +2 more sources

Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex

BMC Genomics, 2009
Background The nuclear receptor superfamily currently consists of seven gene subfamilies that encompass over 80 distinct receptor proteins. These transcription factors typically share a common five-domain structure with a highly conserved DNA-binding ...
Kwon Gwijun, Wang Ying H, Baldwin William S, Thomson Susanne A, LeBlanc Gerald A   +4 more
doaj   +1 more source

Nuclear receptors: a bridge linking the gut microbiome and the host

Molecular Medicine, 2021
Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties
Zixuan Wang, Wei-Dong Chen, Yan-Dong Wang   +2 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology

Pharmacology Research & Perspectives, 2021
This review provides an overview of researches on the NR1 and NR4 nuclear receptors involved in the regulation of microglial functions. Nuclear receptors are attractive candidates for drug targets in the therapies of the central nervous system disorders,
Hiroshi Katsuki
doaj   +1 more source

SnapShot: Nuclear Receptors I

Cell, 2010
Clinical: Flutamide and bicalutamide for prostate cancer and alopeciaGlucocorticoid receptorGR/NR3C1 Endogenous: Cortisol (hydrocortisone) Diverse developmental and physiological roles (e.g., antagonism of inflammatory signaling pathways, mediation of the stress response, and gluconeogenesis)Metabolic, cardiovascular, immune and inflammatory, memory↑
McKenna, Neil J., O'Malley, Bert W.
openaire   +3 more sources