Results 41 to 50 of about 6,710,080 (339)
PPARs as Nuclear Receptors for Nutrient and Energy Metabolism
Molecules, 2019 It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs) were first recognized as enhancers of peroxisome proliferation. Consequently, many studies in different fields have illustrated that PPARs are nuclear receptors that
Fan Hong +4 more
semanticscholar +1 more source
Nuclear Receptor Signaling: A Home for Nuclear Receptor and Coregulator Signaling Research [PDF]
Nuclear Receptor Signaling, 2014 The field of nuclear receptor and coregulator signaling has grown into one of the most active and interdisciplinary in eukaryotic biology. Papers in this field are spread widely across a vast number of journals, which complicates the task of investigators in keeping current with the literature in the field.
McKenna, Neil J. +2 more
openaire +2 more sources
Advances in prostate cancer research models: From transgenic mice to tumor xenografting models
Asian Journal of Urology, 2016 The identification of the origin and molecular characteristics of prostate cancer (PCa) has crucial implications for personalized treatment. The development of effective treatments for PCa has been limited; however, the recent establishment of several ...
Yuejiao Huang +6 more
doaj +1 more source
The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc. [PDF]
PLoS Biology, 2017 Nuclear receptors were originally defined as endocrine sensors in humans, leading to the identification of the nuclear receptor superfamily. Despite intensive efforts, most nuclear receptors have no known ligand, suggesting new ligand classes remain to ...
Kurt Warnhoff +7 more
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Nuclear receptors are important targets of environmental disrupting compounds.
Molecular and Cellular Endocrinology, 2019 Environmental disrupting compounds (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through their interaction with nuclear receptors like the estrogen receptors α and β (ERα and ERβ ...
L. Toporova, P. Balaguer
semanticscholar +1 more source
Regulation of hepatic heme synthesis by drugs, bile acids and nutrition : a transcriptional network regulating [delta]-aminolevulinic acid synthase 1 (ALAS1) [PDF]
, 2008 ALAS1 is the rate limiting enzyme of heme synthesis. It is highly inducible in liver in cases of increased heme demand, such as drug metabolism or in inducible hepatic porphyrias.
Peyer, Anne-Kathrin
core +1 more source
From bench to bedside: the history and progress of CAR T cell therapy
Frontiers in Immunology, 2023 Chimeric antigen receptor (CAR) T cell therapy represents a major breakthrough in cancer care since the approval of tisagenlecleucel by the Food and Drug Administration in 2017 for the treatment of pediatric and young adult patients with relapsed or ...
Aroshi Mitra +8 more
doaj +1 more source
Frontiers in Endocrinology, 2018 27-hydroxycholesterol (27HC) is an abundant cholesterol metabolite in human circulation and promotes breast cancer cell proliferation. Although lung is one of the organs that contain high levels of 27HC, the role of 27HC in lung is unknown. In this study,
Shiro Hiramitsu +19 more
doaj +1 more source
Pathogens, 2023 A hallmark in chronic viral infections are exhausted antigen-specific CD8+ T cell responses and the inability of the immune system to eliminate the virus.
Sebastian Klein +6 more
doaj +1 more source
Targeting nuclear receptors for the treatment of fatty liver disease
Pharmacology and Therapeutics, 2017 Ligand‐activated nuclear receptors, including peroxisome proliferator‐activated receptor alpha (PPAR&agr;), pregnane X receptor, and constitutive androstane receptor, were first identified as key regulators of the responses against chemical toxicants ...
N. Tanaka +3 more
semanticscholar +1 more source