Results 31 to 40 of about 6,710,080 (339)

The role of pregnane X receptor (PXR) in substance metabolism

Frontiers in Endocrinology, 2022
As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a crucial role in the metabolism of xenobiotics and endobiotics in mammals.
Ye Lv, Yi-Yang Luo, Hui-Wen Ren, Hui-Wen Ren, Cheng-Jie Li, Zhi-Xin Xiang, Zhi-Lin Luan, Zhi-Lin Luan   +7 more
doaj   +1 more source

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

Cell, 1998
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1, from a brown fat cDNA library. PGC-1 mRNA expression is
P. Puigserver, Zhidan Wu, Cheol Won Park, R. Graves, M. Wright, B. Spiegelman   +5 more
semanticscholar   +1 more source

Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription [PDF]

, 2020
The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal
Anthony P. Heaney, Zhang, Dongyun, Heaney, Anthony P, Dongyun Zhang   +3 more
core   +1 more source

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]

, 2004
BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer, Handschin, C., Gnerre, C, Sharon Blättler, Meyer, U A, Blattler, S., Handschin, C, Podvinec, M, Oscarson, M., Michael Podvinec, Michel R Kaufmann, Adrian Roth, Kaufmann, M R, Looser, R, Carmela Gnerre, Roth, A., Roth, A, Meyer, U. A., Gnerre, C., Blättler, S, Christoph Handschin, Kaufmann, M. R., Renate Looser, Looser, R., Mikael Oscarson, Oscarson, M, Podvinec, M.   +26 more
core   +1 more source

Dynamics of Nuclear Receptors [PDF]

Structure, 2010
The dynamic properties of VDR LBD and full-length VDR/RXRα heterodimer in the presence and absence of ligands were investigated by hydrogen/deuterium exchange mass spectrometry (Zhang et al., 2010a). The results beautifully complement X-ray crystal structure data.
openaire   +2 more sources

Full-length nuclear receptor allosteric regulation

Journal of Lipid Research, 2023
Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Woong Jae Choi, Zeinab Haratipour, Raymond D. Blind   +2 more
doaj   +1 more source

The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor [PDF]

Journal of Biological Chemistry, 2011
Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors.
X Edward, Zhou, Kelly M, Suino-Powell, Yong, Xu, Cee-Wah, Chan, Osamu, Tanabe, Schoen W, Kruse, Ross, Reynolds, James Douglas, Engel, H Eric, Xu   +8 more
openaire   +2 more sources

The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis [PDF]

Human Reproduction Update, 2014
Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as infertility, pelvic pain, menstrual cycle abnormalities and increased risk of certain cancers.
Sang Jun, Han, Bert W, O'Malley
openaire   +2 more sources

Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function

Frontiers in Immunology, 2021
Nuclear receptors are important bridges between lipid signaling molecules and transcription responses. Beside their role in several developmental and physiological processes, many of these receptors have been shown to regulate and determine the fate of ...
Ahmad Alatshan, Ahmad Alatshan, Szilvia Benkő, Szilvia Benkő   +3 more
doaj   +1 more source

Mixed-model QSAR at the glucocorticoid and liver X receptors [PDF]

, 2009
The presence of hormonally active compounds in the biosphere has become a worldwide environmental concern, and measures such as policy acts and regulations try to address the problem, both in Europe and in the United States.
Spreafico, Morena
core   +1 more source