Results 31 to 40 of about 855,861 (301)
Nuclear receptors in osteoclasts
Current Opinion in Pharmacology, 2020 Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of bone under physiological conditions and numerous pathological conditions, such as osteoporosis, bone metastasis, and inflammatory bone erosion. Nuclear receptors are crucial to various physiological processes, including metabolism, development and inflammation, and ...
Seyeon, Bae +2 more
openaire +3 more sources
The role of pregnane X receptor (PXR) in substance metabolism
Frontiers in Endocrinology, 2022 As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a crucial role in the metabolism of xenobiotics and endobiotics in mammals.
Ye Lv +7 more
doaj +1 more source
Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]
, 2017 Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela +7 more
core +1 more source
Full-length nuclear receptor allosteric regulation
Journal of Lipid Research, 2023 Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Woong Jae Choi +2 more
doaj +1 more source
Dynamics of Nuclear Receptors [PDF]
Structure, 2010 The dynamic properties of VDR LBD and full-length VDR/RXRα heterodimer in the presence and absence of ligands were investigated by hydrogen/deuterium exchange mass spectrometry (Zhang et al., 2010a). The results beautifully complement X-ray crystal structure data.
openaire +2 more sources
Regenerating Rat Liver: Correlations Between Estrogen Receptor Localization and Deoxyribonucleic Acid Synthesis [PDF]
, 1984 Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver and in regenerating rat liver at several time intervals after 75% hepatectomy. Cytosolic estradiol binding in regenerating liver decreases at 12, 24, and 48 h after
Di Leo, A +6 more
core +1 more source
The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor [PDF]
Journal of Biological Chemistry, 2011 Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors.
X Edward, Zhou +8 more
openaire +2 more sources
Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function
Frontiers in Immunology, 2021 Nuclear receptors are important bridges between lipid signaling molecules and transcription responses. Beside their role in several developmental and physiological processes, many of these receptors have been shown to regulate and determine the fate of ...
Ahmad Alatshan +3 more
doaj +1 more source
Virtual screening for PPAR-gamma ligands using the ISOAK molecular graph kernel and gaussian processes [PDF]
, 2009 For a virtual screening study, we introduce a combination of machine learning techniques, employing a graph kernel, Gaussian process regression and clustered cross-validation.
Hansen, Katja +4 more
core +1 more source
The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis [PDF]
Human Reproduction Update, 2014 Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as infertility, pelvic pain, menstrual cycle abnormalities and increased risk of certain cancers.
Sang Jun, Han, Bert W, O'Malley
openaire +2 more sources