The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor [PDF]
Journal of Biological Chemistry, 2011 Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors.
X Edward, Zhou +8 more
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A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors [PDF]
, 2013 Despite their physiological importance, selective interactions between Nuclear Receptors (NRs) and their cofactors are poorly understood. Here we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates its ...
Fulton, J +17 more
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Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function
Frontiers in Immunology, 2021 Nuclear receptors are important bridges between lipid signaling molecules and transcription responses. Beside their role in several developmental and physiological processes, many of these receptors have been shown to regulate and determine the fate of ...
Ahmad Alatshan +3 more
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Nuclear Receptor Signaling: A Home for Nuclear Receptor and Coregulator Signaling Research [PDF]
Nuclear Receptor Signaling, 2014 The field of nuclear receptor and coregulator signaling has grown into one of the most active and interdisciplinary in eukaryotic biology. Papers in this field are spread widely across a vast number of journals, which complicates the task of investigators in keeping current with the literature in the field.
McKenna, Neil J. +2 more
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Mixed-model QSAR at the glucocorticoid and liver X receptors [PDF]
, 2009 The presence of hormonally active compounds in the biosphere has become a worldwide environmental concern, and measures such as policy acts and regulations try to address the problem, both in Europe and in the United States.
Spreafico, Morena
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Advances in prostate cancer research models: From transgenic mice to tumor xenografting models
Asian Journal of Urology, 2016 The identification of the origin and molecular characteristics of prostate cancer (PCa) has crucial implications for personalized treatment. The development of effective treatments for PCa has been limited; however, the recent establishment of several ...
Yuejiao Huang +6 more
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Regulation of hepatic heme synthesis by drugs, bile acids and nutrition : a transcriptional network regulating [delta]-aminolevulinic acid synthase 1 (ALAS1) [PDF]
, 2008 ALAS1 is the rate limiting enzyme of heme synthesis. It is highly inducible in liver in cases of increased heme demand, such as drug metabolism or in inducible hepatic porphyrias.
Peyer, Anne-Kathrin
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The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc. [PDF]
PLoS Biology, 2017 Nuclear receptors were originally defined as endocrine sensors in humans, leading to the identification of the nuclear receptor superfamily. Despite intensive efforts, most nuclear receptors have no known ligand, suggesting new ligand classes remain to ...
Kurt Warnhoff +7 more
doaj +1 more source
From bench to bedside: the history and progress of CAR T cell therapy
Frontiers in Immunology, 2023 Chimeric antigen receptor (CAR) T cell therapy represents a major breakthrough in cancer care since the approval of tisagenlecleucel by the Food and Drug Administration in 2017 for the treatment of pediatric and young adult patients with relapsed or ...
Aroshi Mitra +8 more
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Ethylene signalling receptors and transcription factors over the grape berry development: gene expression profiling [PDF]
, 2010 The ethylene signalling pathway has never been fully described in grapes. Regarded as a non-climacteric fruit, grape berry seems to ripen independently to ethylene, however 1-methylcyclopropene (1-MCP), a specific inhibitor of ethylene receptors has been
Chervin, Christian +4 more
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