Results 11 to 20 of about 6,710,080 (339)
Nuclear receptors: from molecular mechanisms to therapeutics
Essays in Biochemistry, 2021 Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases.
Daniel E. Frigo +2 more
semanticscholar +2 more sources
Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription
Cells, 2020 Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans.
Lian Jing Tao +4 more
doaj +2 more sources
Viruses, 2021 Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in HPV-
Seoung-Ae Lee +4 more
doaj +1 more source
Biomolecules, 2023 Liver X receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors which regulate the expression of lipid and cholesterol metabolism genes.
Asitha Premaratne +5 more
doaj +1 more source
Genes, 2021 Obesity and type 2 diabetes mellitus (T2DM) are metabolic disorders characterized by metabolic inflexibility with multiple pathological organ manifestations, including non-alcoholic fatty liver disease (NAFLD).
E. Dixon +3 more
semanticscholar +1 more source
Current strategies in engaging oncolytic viruses with antitumor immunity
Molecular Therapy: Oncolytics, 2021 Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni +2 more
doaj +1 more source
Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.
Journal of Medicinal Chemistry, 2021 Nuclear receptors, also known as ligand-activated transcription factors, regulate gene expression upon ligand signals and present as attractive therapeutic targets especially in chronic diseases.
Sabine Willems, Daniel Zaienne, D. Merk
semanticscholar +1 more source
Liver X Receptor Regulation of Glial Cell Functions in the CNS
Biomedicines, 2022 In this review, we discuss the role of liver X receptors (LXRs) in glial cells (microglia, oligodendrocytes and astrocytes) in the central nervous system (CNS).
Xiaoyu Song +3 more
doaj +1 more source
Nuclear Receptors in Liver Fibrosis.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021 Nuclear receptors are ligand-activated transcription factors that regulate gene expression of a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver fibrogenesis are activated hepatic stellate cells. Different
Philipp Königshofer +6 more
semanticscholar +1 more source
British Journal of Pharmacology, 2007 ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
S. P. H. Alexander +2 more
openaire +3 more sources