Results 11 to 20 of about 548,108 (301)
Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription
Cells, 2020 Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans.
Lian Jing Tao +4 more
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Targeting Nuclear Receptors with Marine Natural Products [PDF]
Marine Drugs, 2014 Nuclear receptors (NRs) are important pharmaceutical targets because they are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis.
Chunyan Yang, Qianrong Li, Yong Li
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Nuclear Receptors in Vascular Biology [PDF]
Current Atherosclerosis Reports, 2015 Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics. In response to these diverse but critically important mediators, nuclear receptors regulate the homeostatic control of lipids, carbohydrate ...
Bishop-Bailey, D, David Bishop-Bailey
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Cells, 2023 Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and, consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is known about the mechanisms for lncRNA degradation.
Maram Quttina +8 more
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Journal for ImmunoTherapy of Cancer, 2021 Background Although oncolytic virotherapy has shown substantial promises as a new treatment modality for many malignancies, further improvement on its therapeutic efficacy will likely bring more clinical benefits.
Guangsheng Pei +5 more
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The nuclear receptor superfamily [PDF]
Journal of Cell Science, 2003 Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see [Laudet and Gronemeyer, 2002][1]).
Robinson-Rechavi, M. +2 more
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Cell Communication and Signaling, 2020 Background Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable metastatic disease.
Shaymaa Bahnassy +8 more
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Molecular Therapy: Oncolytics, 2021 The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala +3 more
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Signaling by Nuclear Receptors [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Nuclear receptors are activated by lipid-soluble signals (e.g., steroid hormones) that cross the plasma membrane. Once activated, most function as transcription factors to control gene expression for numerous biological processes.
Richard, Sever, Christopher K, Glass
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Nuclear receptors : from molecular mechanisms to therapeutics
, 2021 Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases.
Frigo, Daniel E., +5 more
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